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Items: 1 to 20 of 359

1.

Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders.

Evers JM, Laskowski RA, Bertolli M, Clayton-Smith J, Deshpande C, Eason J, Elmslie F, Flinter F, Gardiner C, Hurst JA, Kingston H, Kini U, Lampe AK, Lim D, Male A, Naik S, Parker MJ, Price S, Robert L, Sarkar A, Straub V, Woods G, Thornton JM; DDD Study., Wright CF.

Hum Mol Genet. 2017 Jan 4. pii: ddw409. doi: 10.1093/hmg/ddw409. [Epub ahead of print]

2.

Modeling birds on wires.

Aydoğdu A, Frasca P, D'Apice C, Manzo R, Thornton JM, Gachomo B, Wilson T, Cheung B, Tariq U, Saidel W, Piccoli B.

J Theor Biol. 2017 Feb 21;415:102-112. doi: 10.1016/j.jtbi.2016.11.026.

PMID:
27932298
3.

Chopping and Changing: the Evolution of the Flavin-dependent Monooxygenases.

Mascotti ML, Juri Ayub M, Furnham N, Thornton JM, Laskowski RA.

J Mol Biol. 2016 Jul 31;428(15):3131-46. doi: 10.1016/j.jmb.2016.07.003.

4.

Reaction Decoder Tool (RDT): extracting features from chemical reactions.

Rahman SA, Torrance G, Baldacci L, Martínez Cuesta S, Fenninger F, Gopal N, Choudhary S, May JW, Holliday GL, Steinbeck C, Thornton JM.

Bioinformatics. 2016 Jul 1;32(13):2065-6. doi: 10.1093/bioinformatics/btw096.

5.

Exploring the chemistry and evolution of the isomerases.

Martínez Cuesta S, Rahman SA, Thornton JM.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1796-801. doi: 10.1073/pnas.1509494113.

6.

Characterising Complex Enzyme Reaction Data.

Dönertaş HM, Martínez Cuesta S, Rahman SA, Thornton JM.

PLoS One. 2016 Feb 3;11(2):e0147952. doi: 10.1371/journal.pone.0147952.

7.

Integrating population variation and protein structural analysis to improve clinical interpretation of missense variation: application to the WD40 domain.

Laskowski RA, Tyagi N, Johnson D, Joss S, Kinning E, McWilliam C, Splitt M, Thornton JM, Firth HV; DDD Study., Wright CF.

Hum Mol Genet. 2016 Mar 1;25(5):927-35. doi: 10.1093/hmg/ddv625.

8.

Proteins: interaction at a distance.

Laskowski RA, Thornton JM.

IUCrJ. 2015 Oct 30;2(Pt 6):609-10. doi: 10.1107/S2052252515020217.

9.

Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies.

Furnham N, Dawson NL, Rahman SA, Thornton JM, Orengo CA.

J Mol Biol. 2016 Jan 29;428(2 Pt A):253-67. doi: 10.1016/j.jmb.2015.11.010.

10.

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.

Tyagi N, Farnell EJ, Fitzsimmons CM, Ryan S, Tukahebwa E, Maizels RM, Dunne DW, Thornton JM, Furnham N.

PLoS Comput Biol. 2015 Oct 29;11(10):e1004546. doi: 10.1371/journal.pcbi.1004546.

11.

Monitoring the health of the work environment with a daily assessment tool: the REAL - Relative Environment Assessment Lens - indicator.

Hinsley KE, Marshall AC, Hurtig MH, Thornton JM, O'Connell CA, Porter CL, Connor JA, Hickey PA.

Cardiol Young. 2016 Aug;26(6):1082-9. doi: 10.1017/S1047951115001808.

PMID:
26423013
12.

SurvCurv database and online survival analysis platform update.

Ziehm M, Ivanov DK, Bhat A, Partridge L, Thornton JM.

Bioinformatics. 2015 Dec 1;31(23):3878-80. doi: 10.1093/bioinformatics/btv463.

13.

The Classification and Evolution of Enzyme Function.

Martínez Cuesta S, Rahman SA, Furnham N, Thornton JM.

Biophys J. 2015 Sep 15;109(6):1082-6. doi: 10.1016/j.bpj.2015.04.020. Review.

14.

Longevity GWAS Using the Drosophila Genetic Reference Panel.

Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM.

J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1470-8. doi: 10.1093/gerona/glv047.

15.

Endovascular treatment for Small Core and Anterior circulation Proximal occlusion with Emphasis on minimizing CT to recanalization times (ESCAPE) trial: methodology.

Demchuk AM, Goyal M, Menon BK, Eesa M, Ryckborst KJ, Kamal N, Patil S, Mishra S, Almekhlafi M, Randhawa PA, Roy D, Willinsky R, Montanera W, Silver FL, Shuaib A, Rempel J, Jovin T, Frei D, Sapkota B, Thornton JM, Poppe A, Tampieri D, Lum C, Weill A, Sajobi TT, Hill MD; ESCAPE Trial Investigators..

Int J Stroke. 2015 Apr;10(3):429-38. doi: 10.1111/ijs.12424.

PMID:
25546514
16.

Comparison of the mammalian insulin signalling pathway to invertebrates in the context of FOXO-mediated ageing.

Papatheodorou I, Petrovs R, Thornton JM.

Bioinformatics. 2014 Nov 1;30(21):2999-3003. doi: 10.1093/bioinformatics/btu493.

17.

The evolution of enzyme function in the isomerases.

Martinez Cuesta S, Furnham N, Rahman SA, Sillitoe I, Thornton JM.

Curr Opin Struct Biol. 2014 Jun;26:121-30. doi: 10.1016/j.sbi.2014.06.002. Review.

18.

Exploring the biological and chemical complexity of the ligases.

Holliday GL, Rahman SA, Furnham N, Thornton JM.

J Mol Biol. 2014 May 15;426(10):2098-111. doi: 10.1016/j.jmb.2014.03.008. Review.

19.

MDL-1, a growth- and tumor-suppressor, slows aging and prevents germline hyperplasia and hypertrophy in C. elegans.

Riesen M, Feyst I, Rattanavirotkul N, Ezcurra M, Tullet JM, Papatheodorou I, Ziehm M, Au C, Gilliat AF, Hellberg J, Thornton JM, Gems D.

Aging (Albany NY). 2014 Feb;6(2):98-117.

20.

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.

Tullet JM, Araiz C, Sanders MJ, Au C, Benedetto A, Papatheodorou I, Clark E, Schmeisser K, Jones D, Schuster EF, Thornton JM, Gems D.

PLoS Genet. 2014 Feb 6;10(2):e1004109. doi: 10.1371/journal.pgen.1004109.

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