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Items: 1 to 20 of 84

1.

Reconstructing Ancient Proteins to Understand the Causes of Structure and Function.

Hochberg GK, Thornton JW.

Annu Rev Biophys. 2017 Mar 15. doi: 10.1146/annurev-biophys-070816-033631. [Epub ahead of print]

PMID:
28301769
2.

Exploring protein sequence-function landscapes.

Starr TN, Thornton JW.

Nat Biotechnol. 2017 Feb 8;35(2):125-126. doi: 10.1038/nbt.3786. No abstract available.

PMID:
28178247
3.

Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.

Eick GN, Bridgham JT, Anderson DP, Harms MJ, Thornton JW.

Mol Biol Evol. 2017 Feb 1;34(2):247-261. doi: 10.1093/molbev/msw223.

PMID:
27795231
4.

A second estrogen receptor from Japanese lamprey (Lethenteron japonicum) does not have activities for estrogen binding and transcription.

Katsu Y, Cziko PA, Chandsawangbhuwana C, Thornton JW, Sato R, Oka K, Takei Y, Baker ME, Iguchi T.

Gen Comp Endocrinol. 2016 Sep 15;236:105-14. doi: 10.1016/j.ygcen.2016.07.014. Epub 2016 Jul 16.

PMID:
27432813
5.
6.

Epistasis in protein evolution.

Starr TN, Thornton JW.

Protein Sci. 2016 Jul;25(7):1204-18. doi: 10.1002/pro.2897. Epub 2016 Feb 28. Review.

PMID:
26833806
7.

Correction: Evolution of an ancient protein function involved in organized multicellularity in animals.

Anderson DP, Whitney DS, Hanson-Smith V, Woznica A, Campodonico-Burnett W, Volkman BF, King N, Thornton JW, Prehoda KE.

Elife. 2016 Jan 21;5:e14311. doi: 10.7554/eLife.14311. No abstract available.

8.

Evolution of an ancient protein function involved in organized multicellularity in animals.

Anderson DP, Whitney DS, Hanson-Smith V, Woznica A, Campodonico-Burnett W, Volkman BF, King N, Thornton JW, Prehoda KE.

Elife. 2016 Jan 7;5:e10147. doi: 10.7554/eLife.10147. Erratum in: Elife. 2016;5:e14311.

9.

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.

Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z; IMAC-2 and IPAC Investigators..

N Engl J Med. 2016 Jan 21;374(3):233-41. doi: 10.1056/NEJMoa1505517. Epub 2016 Jan 6.

10.

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.

Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):326-31. doi: 10.1073/pnas.1518960113. Epub 2015 Dec 29.

11.

Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites.

Anderson DW, McKeown AN, Thornton JW.

Elife. 2015 Jun 15;4:e07864. doi: 10.7554/eLife.07864.

12.

Thermodynamic system drift in protein evolution.

Hart KM, Harms MJ, Schmidt BH, Elya C, Thornton JW, Marqusee S.

PLoS Biol. 2014 Nov 11;12(11):e1001994. doi: 10.1371/journal.pbio.1001994. eCollection 2014 Nov. Erratum in: PLoS Biol. 2015 Feb;13(2):e1002091.

13.

Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.

McKeown AN, Bridgham JT, Anderson DW, Murphy MN, Ortlund EA, Thornton JW.

Cell. 2014 Sep 25;159(1):58-68. doi: 10.1016/j.cell.2014.09.003.

14.

A thrombus in transit through a patent foramen ovale.

Ibebuogu UN, Khouzam RN, Sharma G, Thornton JW, Robati R, Silverman D.

JAAPA. 2014 Oct;27(10):32-5. doi: 10.1097/01.JAA.0000446233.16049.01.

PMID:
25251652
15.

Historical contingency and its biophysical basis in glucocorticoid receptor evolution.

Harms MJ, Thornton JW.

Nature. 2014 Aug 14;512(7513):203-7. doi: 10.1038/nature13410. Epub 2014 Jun 15.

16.

Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor.

Bridgham JT, Keay J, Ortlund EA, Thornton JW.

PLoS Genet. 2014 Jan;10(1):e1004058. doi: 10.1371/journal.pgen.1004058. Epub 2014 Jan 9.

17.

Evolutionary biochemistry: revealing the historical and physical causes of protein properties.

Harms MJ, Thornton JW.

Nat Rev Genet. 2013 Aug;14(8):559-71. doi: 10.1038/nrg3540. Review.

18.

Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.

Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11475-80. doi: 10.1073/pnas.1303930110. Epub 2013 Jun 24.

19.

Evolution of minimal specificity and promiscuity in steroid hormone receptors.

Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW.

PLoS Genet. 2012;8(11):e1003072. doi: 10.1371/journal.pgen.1003072. Epub 2012 Nov 15.

20.

The interface of protein structure, protein biophysics, and molecular evolution.

Liberles DA, Teichmann SA, Bahar I, Bastolla U, Bloom J, Bornberg-Bauer E, Colwell LJ, de Koning AP, Dokholyan NV, Echave J, Elofsson A, Gerloff DL, Goldstein RA, Grahnen JA, Holder MT, Lakner C, Lartillot N, Lovell SC, Naylor G, Perica T, Pollock DD, Pupko T, Regan L, Roger A, Rubinstein N, Shakhnovich E, Sjölander K, Sunyaev S, Teufel AI, Thorne JL, Thornton JW, Weinreich DM, Whelan S.

Protein Sci. 2012 Jun;21(6):769-85. doi: 10.1002/pro.2071. Epub 2012 Apr 23. Review.

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