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Items: 1 to 20 of 42

1.

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus.

Zhao J, Cheah SE, Roberts KD, Nation RL, Thompson PE, Velkov T, Du Z, Johnson MD, Li J.

mSphere. 2016 Jul 27;1(4). pii: e00119-16. doi: 10.1128/mSphere.00119-16. eCollection 2016 Jul-Aug.

2.

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.

Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, Pabreja K, Simms J, Sridhar R, Furness SG, Liu M, Thompson PE, Miller LJ, Christopoulos A, Sexton PM.

Cell. 2016 Jun 16;165(7):1632-43. doi: 10.1016/j.cell.2016.05.023.

3.

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes.

Yun B, Azad MA, Nowell CJ, Nation RL, Thompson PE, Roberts KD, Velkov T, Li J.

Antimicrob Agents Chemother. 2015 Dec;59(12):7489-96. doi: 10.1128/AAC.01216-15. Epub 2015 Sep 21.

4.

Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.

Mountford SJ, Zheng Z, Sundaram K, Jennings IG, Hamilton JR, Thompson PE.

ACS Med Chem Lett. 2014 Sep 24;6(1):3-6. doi: 10.1021/ml500354e. eCollection 2015 Jan 8.

5.

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach.

Azad MA, Roberts KD, Yu HH, Liu B, Schofield AV, James SA, Howard DL, Nation RL, Rogers K, de Jonge MD, Thompson PE, Fu J, Velkov T, Li J.

Anal Chem. 2015 Feb 3;87(3):1590-5. doi: 10.1021/ac504516k. Epub 2015 Jan 15.

6.

Imaging the distribution of polymyxins in the kidney.

Yun B, Azad MA, Wang J, Nation RL, Thompson PE, Roberts KD, Velkov T, Li J.

J Antimicrob Chemother. 2015 Mar;70(3):827-9. doi: 10.1093/jac/dku441. Epub 2014 Nov 5.

7.

Measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?

Azad MA, Yun B, Roberts KD, Nation RL, Thompson PE, Velkov T, Li J.

Antimicrob Agents Chemother. 2014 Oct;58(10):6337-8. doi: 10.1128/AAC.03733-14. No abstract available.

8.

Structural basis of nSH2 regulation and lipid binding in PI3Kα.

Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB.

Oncotarget. 2014 Jul 30;5(14):5198-208.

9.

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria.

Deris ZZ, Swarbrick JD, Roberts KD, Azad MA, Akter J, Horne AS, Nation RL, Rogers KL, Thompson PE, Velkov T, Li J.

Bioconjug Chem. 2014 Apr 16;25(4):750-60. doi: 10.1021/bc500094d. Epub 2014 Mar 27.

10.

Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.

Velkov T, Roberts KD, Nation RL, Wang J, Thompson PE, Li J.

ACS Chem Biol. 2014 May 16;9(5):1172-7. doi: 10.1021/cb500080r. Epub 2014 Mar 17.

11.

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity.

Deris ZZ, Akter J, Sivanesan S, Roberts KD, Thompson PE, Nation RL, Li J, Velkov T.

J Antibiot (Tokyo). 2014 Feb;67(2):147-51. doi: 10.1038/ja.2013.111. Epub 2013 Oct 30.

12.

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

McCoy LS, Roberts KD, Nation RL, Thompson PE, Velkov T, Li J, Tor Y.

Chembiochem. 2013 Nov 4;14(16):2083-6. doi: 10.1002/cbic.201300496. Epub 2013 Sep 18.

13.

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ

Pinson JA, Zheng Z, Miller MS, Chalmers DK, Jennings IG, Thompson PE.

ACS Med Chem Lett. 2013 Feb 14;4(2):206-210.

14.

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats.

He H, Li JC, Nation RL, Jacob J, Chen G, Lee HJ, Tsuji BT, Thompson PE, Roberts K, Velkov T, Li J.

J Antimicrob Chemother. 2013 Oct;68(10):2311-7. doi: 10.1093/jac/dkt207. Epub 2013 Jun 7.

15.

Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.

Velkov T, Roberts KD, Nation RL, Thompson PE, Li J.

Future Microbiol. 2013 Jun;8(6):711-24. doi: 10.2217/fmb.13.39. Review.

16.

Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.

Wijeyewickrema LC, Yongqing T, Tran TP, Thompson PE, Viljoen JE, Coetzer TH, Duncan RC, Kass I, Buckle AM, Pike RN.

J Biol Chem. 2013 May 31;288(22):15571-80. doi: 10.1074/jbc.M113.451757. Epub 2013 Apr 15.

17.

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.

Nguyen W, Howard BL, Jenkins DP, Wulff H, Thompson PE, Manallack DT.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7106-9. doi: 10.1016/j.bmcl.2012.09.080. Epub 2012 Sep 29.

18.

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.

Velkov T, Soon RL, Chong PL, Huang JX, Cooper MA, Azad MA, Baker MA, Thompson PE, Roberts K, Nation RL, Clements A, Strugnell RA, Li J.

Innate Immun. 2013 Jun;19(3):265-77. doi: 10.1177/1753425912459092. Epub 2012 Sep 24.

19.

Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.

Azad MA, Huang JX, Cooper MA, Roberts KD, Thompson PE, Nation RL, Li J, Velkov T.

Biochem Pharmacol. 2012 Aug 1;84(3):278-91. doi: 10.1016/j.bcp.2012.05.004. Epub 2012 May 12.

20.

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

Zheng Z, Amran SI, Zhu J, Schmidt-Kittler O, Kinzler KW, Vogelstein B, Shepherd PR, Thompson PE, Jennings IG.

Biochem J. 2012 Jun 15;444(3):529-35. doi: 10.1042/BJ20120499.

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