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Items: 11


Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees.

Laughlin MH, Yang HT, Tharp DL, Rector RS, Padilla J, Bowles DK.

Microcirculation. 2017 Feb;24(2). doi: 10.1111/micc.12336. Review.


Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exercise.

Bender SB, de Beer VJ, Tharp DL, Bowles DK, Laughlin MH, Merkus D, Duncker DJ.

Basic Res Cardiol. 2016 Nov;111(6):61. doi: 10.1007/s00395-016-0579-9. Epub 2016 Sep 13.


Upregulation of intermediate-conductance Ca2+-activated K+ channels (KCNN4) in porcine coronary smooth muscle requires NADPH oxidase 5 (NOX5).

Gole HK, Tharp DL, Bowles DK.

PLoS One. 2014 Aug 21;9(8):e105337. doi: 10.1371/journal.pone.0105337. eCollection 2014.


Ovariectomy increases L-type Ca(2+) channel activity in porcine coronary smooth muscle.

Tharp DL, Ivey JR, Shaw RL, Bowles DK.

Menopause. 2014 Jun;21(6):661-8. doi: 10.1097/GME.0000000000000087.


Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia.

Bender SB, de Beer VJ, Tharp DL, van Deel ED, Bowles DK, Duncker DJ, Laughlin MH, Merkus D.

J Physiol. 2014 Apr 15;592(8):1757-69. doi: 10.1113/jphysiol.2013.267351. Epub 2014 Jan 13.


Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability.

de Beer VJ, Merkus D, Bender SB, Tharp DL, Bowles DK, Duncker DJ, Laughlin MH.

J Appl Physiol (1985). 2013 Dec;115(12):1767-76. doi: 10.1152/japplphysiol.00619.2013. Epub 2013 Oct 24.


Ovariectomy increases L-type calcium channel activity in porcine coronary smooth muscle.

Tharp DL, Ivey JR, Shaw RL, Bowles DK.

Menopause. 2013 Oct 7. [Epub ahead of print]


Low-intensity interval exercise training attenuates coronary vascular dysfunction and preserves Ca²⁺-sensitive K⁺ current in miniature swine with LV hypertrophy.

Emter CA, Tharp DL, Ivey JR, Ganjam VK, Bowles DK.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1687-94. doi: 10.1152/ajpheart.00610.2011. Epub 2011 Aug 12.


The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.

Long X, Tharp DL, Georger MA, Slivano OJ, Lee MY, Wamhoff BR, Bowles DK, Miano JM.

J Biol Chem. 2009 Nov 27;284(48):33671-82. doi: 10.1074/jbc.M109.050419. Epub 2009 Oct 1.


Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine.

Tharp DL, Masseau I, Ivey J, Ganjam VK, Bowles DK.

Cardiovasc Res. 2009 Apr 1;82(1):152-60. doi: 10.1093/cvr/cvp038. Epub 2009 Jan 30.


PKCdelta mediates testosterone-induced increases in coronary smooth muscle Cav1.2.

Maddali KK, Korzick DH, Tharp DL, Bowles DK.

J Biol Chem. 2005 Dec 30;280(52):43024-9. Epub 2005 Oct 21.

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