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Items: 13


dsRNA in immunometabolism.

Nakamura T.

Oncotarget. 2015 Aug 21;6(24):19940-1. No abstract available.


Potential role for snoRNAs in PKR activation during metabolic stress.

Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BL.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5023-8. doi: 10.1073/pnas.1424044112. Epub 2015 Apr 6.


A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2╬▒ phosphorylation in obesity.

Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS.

Cell Rep. 2015 Apr 14;11(2):295-307. doi: 10.1016/j.celrep.2015.03.021. Epub 2015 Apr 2.


Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS.

Diabetes. 2014 Feb;63(2):526-34. doi: 10.2337/db13-1019. Epub 2013 Oct 22.


Novel role of PKR in inflammasome activation and HMGB1 release.

Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundb├Ąck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ.

Nature. 2012 Aug 30;488(7413):670-4. doi: 10.1038/nature11290.


Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.

Morita M, Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T.

EMBO J. 2011 Sep 6;30(22):4678-91. doi: 10.1038/emboj.2011.320.


Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS.

Cell. 2010 Feb 5;140(3):338-48. doi: 10.1016/j.cell.2010.01.001.


Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.

Horiuchi M, Takeuchi K, Noda N, Muroya N, Suzuki T, Nakamura T, Kawamura-Tsuzuku J, Takahasi K, Yamamoto T, Inagaki F.

J Biol Chem. 2009 May 8;284(19):13244-55. doi: 10.1074/jbc.M809250200. Epub 2009 Mar 10.


Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.

Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T.

Mol Cell Biol. 2007 Jul;27(13):4980-90. Epub 2007 Apr 23.


Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene.

Kawa S, Ito C, Toyama Y, Maekawa M, Tezuka T, Nakamura T, Nakazawa T, Yokoyama K, Yoshida N, Toshimori K, Yamamoto T.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19344-9. Epub 2006 Dec 8.


Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways.

Kimura H, Nakamura T, Ogawa T, Tanaka S, Shiota K.

Nucleic Acids Res. 2003 Jun 15;31(12):3101-13.


Mice lacking a transcriptional corepressor Tob are predisposed to cancer.

Yoshida Y, Nakamura T, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T.

Genes Dev. 2003 May 15;17(10):1201-6.


Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.

Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T.

Genes Dev. 2002 Jun 1;16(11):1356-70.

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