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A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release.

Alcaino C, Knutson KR, Treichel AJ, Yildiz G, Strege PR, Linden DR, Li JH, Leiter AB, Szurszewski JH, Farrugia G, Beyder A.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7632-E7641. doi: 10.1073/pnas.1804938115. Epub 2018 Jul 23.


High temporal resolution gastric emptying breath tests in mice.

Miller KE, Bajzer Ž, Hein SS, Phillips JE, Syed S, Wright AM, Cipriani G, Gibbons SJ, Szurszewski JH, Farrugia G, Ordog T, Linden DR.

Neurogastroenterol Motil. 2018 Mar 25:e13333. doi: 10.1111/nmo.13333. [Epub ahead of print]


Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice.

Cipriani G, Gibbons SJ, Miller KE, Yang DS, Terhaar ML, Eisenman ST, Ördög T, Linden DR, Gajdos GB, Szurszewski JH, Farrugia G.

Gastroenterology. 2018 Jun;154(8):2122-2136.e12. doi: 10.1053/j.gastro.2018.02.027. Epub 2018 Mar 6.


Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release.

Strege PR, Knutson K, Eggers SJ, Li JH, Wang F, Linden D, Szurszewski JH, Milescu L, Leiter AB, Farrugia G, Beyder A.

Sci Rep. 2017 Nov 15;7(1):15650. doi: 10.1038/s41598-017-15834-3.


Extracellular Cl- regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum.

Saravanaperumal SA, Gibbons SJ, Malysz J, Sha L, Linden DR, Szurszewski JH, Farrugia G.

Exp Physiol. 2018 Jan 1;103(1):40-57. doi: 10.1113/EP086367. Epub 2017 Nov 2.


Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.

Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Apr 23;2(4):454-467. eCollection 2016 Jul.


Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction.

Chen J, Toyomasu Y, Hayashi Y, Linden DR, Szurszewski JH, Nelson H, Farrugia G, Kashyap PC, Chia N, Ordog T.

Genome Med. 2016 Oct 3;8(1):103.


Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes.

Reigstad CS, Linden DR, Szurszewski JH, Sonnenburg JL, Farrugia G, Kashyap PC.

Neurogastroenterol Motil. 2016 Sep;28(9):1443-8. doi: 10.1111/nmo.12840. Epub 2016 Apr 12.


Diabetic Csf1op/op mice lacking macrophages are protected against the development of delayed gastric emptying.

Cipriani G, Gibbons SJ, Verhulst PJ, Choi KM, Eisenman ST, Hein SS, Ordog T, Linden DR, Szurszewski JH, Farrugia G.

Cell Mol Gastroenterol Hepatol. 2016 Jan 1;2(1):40-47.


Changes in nitrergic and tachykininergic pathways in rat proximal colon in response to chronic treatment with otilonium bromide.

Cipriani G, Gibbons SJ, Saravanaperumal SA, Malysz J, Sha L, Szurszewski JH, Linden DR, Evangelista S, Faussone-Pellegrini MS, Vannucchi MG, Farrugia G.

Neurogastroenterol Motil. 2015 Jul;27(7):997-1009. doi: 10.1111/nmo.12576. Epub 2015 Apr 30.


Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells.

Reigstad CS, Salmonson CE, Rainey JF 3rd, Szurszewski JH, Linden DR, Sonnenburg JL, Farrugia G, Kashyap PC.

FASEB J. 2015 Apr;29(4):1395-403. doi: 10.1096/fj.14-259598. Epub 2014 Dec 30.


Ano1, a Ca2+-activated Cl- channel, coordinates contractility in mouse intestine by Ca2+ transient coordination between interstitial cells of Cajal.

Singh RD, Gibbons SJ, Saravanaperumal SA, Du P, Hennig GW, Eisenman ST, Mazzone A, Hayashi Y, Cao C, Stoltz GJ, Ordog T, Rock JR, Harfe BD, Szurszewski JH, Farrugia G.

J Physiol. 2014 Sep 15;592(18):4051-68. doi: 10.1113/jphysiol.2014.277152. Epub 2014 Jul 25.


Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract.

Farrugia G, Szurszewski JH.

Gastroenterology. 2014 Aug;147(2):303-13. doi: 10.1053/j.gastro.2014.04.041. Epub 2014 May 2. Review.


Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle.

Sha L, Linden DR, Farrugia G, Szurszewski JH.

J Physiol. 2014 Mar 1;592(5):1077-89. doi: 10.1113/jphysiol.2013.266841. Epub 2013 Dec 23.


Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion.

Sha L, Linden DR, Farrugia G, Szurszewski JH.

J Neurosci. 2013 Jul 31;33(31):12638-46. doi: 10.1523/JNEUROSCI.4429-12.2013.


Assessment of gastric emptying in non-obese diabetic mice using a [13C]-octanoic acid breath test.

Creedon CT, Verhulst PJ, Choi KM, Mason JE, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G.

J Vis Exp. 2013 Mar 23;(73):e50301. doi: 10.3791/50301.


Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS.

Linden DR, Furne J, Stoltz GJ, Abdel-Rehim MS, Levitt MD, Szurszewski JH.

Br J Pharmacol. 2012 Apr;165(7):2178-90. doi: 10.1111/j.1476-5381.2011.01681.x.


Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.

Strege PR, Bernard CE, Kraichely RE, Mazzone A, Sha L, Beyder A, Gibbons SJ, Linden DR, Kendrick ML, Sarr MG, Szurszewski JH, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G1105-14. doi: 10.1152/ajpgi.00556.2010. Epub 2011 Mar 10.


Altered expression of Ano1 variants in human diabetic gastroparesis.

Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP, Linden DR, Szurszewski JH, Ördög T, Gibbons SJ, Farrugia G.

J Biol Chem. 2011 Apr 15;286(15):13393-403. doi: 10.1074/jbc.M110.196089. Epub 2011 Feb 24.


The transwall gradient across the mouse colonic circular muscle layer is carbon monoxide dependent.

Sha L, Farrugia G, Linden DR, Szurszewski JH.

FASEB J. 2010 Oct;24(10):3840-9. doi: 10.1096/fj.10-156232. Epub 2010 Jun 11.

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