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Items: 1 to 20 of 238

1.

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.

Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7659-7664. doi: 10.1073/pnas.1704006114. Epub 2017 Jul 3.

2.

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation.

Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW.

J Am Chem Soc. 2017 Jul 5;139(26):8780-8783. doi: 10.1021/jacs.7b01562. Epub 2017 Jun 22.

PMID:
28640999
3.

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides.

Stairs S, Nikmal A, Bučar DK, Zheng SL, Szostak JW, Powner MW.

Nat Commun. 2017 May 19;8:15270. doi: 10.1038/ncomms15270.

4.

The Narrow Road to the Deep Past.

Szostak JW.

Angew Chem Int Ed Engl. 2017 May 17. doi: 10.1002/anie.201704048. [Epub ahead of print]

PMID:
28514493
5.

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides.

Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW.

J Am Chem Soc. 2017 Feb 8;139(5):1810-1813. doi: 10.1021/jacs.6b13148. Epub 2017 Jan 24.

6.

Unusual Base-Pairing Interactions in Monomer-Template Complexes.

Zhang W, Tam CP, Wang J, Szostak JW.

ACS Cent Sci. 2016 Dec 28;2(12):916-926. doi: 10.1021/acscentsci.6b00278. Epub 2016 Nov 2.

7.

Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes.

Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW.

J Am Chem Soc. 2017 Jan 18;139(2):571-574. doi: 10.1021/jacs.6b09760. Epub 2017 Jan 5.

PMID:
28055190
8.

N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes.

Izgu EC, Björkbom A, Kamat NP, Lelyveld VS, Zhang W, Jia TZ, Szostak JW.

J Am Chem Soc. 2016 Dec 28;138(51):16669-16676. doi: 10.1021/jacs.6b08801. Epub 2016 Dec 13.

PMID:
27959544
9.

Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension.

Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW.

Chem Commun (Camb). 2016 Sep 29;52(80):11905-11907.

PMID:
27722518
10.

Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.

Jia TZ, Fahrenbach AC, Kamat NP, Adamala KP, Szostak JW.

Nat Chem. 2016 Oct;8(10):915-21. doi: 10.1038/nchem.2551. Epub 2016 Jun 27.

11.

On the origin of life.

Szostak JW.

Medicina (B Aires). 2016;76(4):199-203.

12.

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension.

Walton T, Szostak JW.

J Am Chem Soc. 2016 Sep 14;138(36):11996-2002. doi: 10.1021/jacs.6b07977. Epub 2016 Sep 1.

PMID:
27552367
13.

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides.

Prywes N, Blain JC, Del Frate F, Szostak JW.

Elife. 2016 Jun 28;5. pii: e17756. doi: 10.7554/eLife.17756.

14.

Thiolated uridine substrates and templates improve the rate and fidelity of ribozyme-catalyzed RNA copying.

Prywes N, Michaels YS, Pal A, Oh SS, Szostak JW.

Chem Commun (Camb). 2016 May 5;52(39):6529-32. doi: 10.1039/c6cc02692c.

PMID:
27109314
15.

A simple physical mechanism enables homeostasis in primitive cells.

Engelhart AE, Adamala KP, Szostak JW.

Nat Chem. 2016 May;8(5):448-53. doi: 10.1038/nchem.2475. Epub 2016 Mar 14.

16.

Collaboration between primitive cell membranes and soluble catalysts.

Adamala KP, Engelhart AE, Szostak JW.

Nat Commun. 2016 Mar 21;7:11041. doi: 10.1038/ncomms11041.

17.

Experimental and Computational Evidence for a Loose Transition State in Phosphoroimidazolide Hydrolysis.

Li L, Lelyveld VS, Prywes N, Szostak JW.

J Am Chem Soc. 2016 Mar 30;138(12):3986-9. doi: 10.1021/jacs.6b00784. Epub 2016 Mar 17.

PMID:
26974265
18.

Synthesis of activated 3'-amino-3'-deoxy-2-thio-thymidine, a superior substrate for the nonenzymatic copying of nucleic acid templates.

Izgu EC, Oh SS, Szostak JW.

Chem Commun (Camb). 2016 Mar 4;52(18):3684-6. doi: 10.1039/c5cc10317g.

PMID:
26857159
19.

Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides.

Lelyveld VS, Björkbom A, Ransey EM, Sliz P, Szostak JW.

J Am Chem Soc. 2015 Dec 16;137(49):15378-81. doi: 10.1021/jacs.5b10596. Epub 2015 Dec 3.

20.

Bidirectional Direct Sequencing of Noncanonical RNA by Two-Dimensional Analysis of Mass Chromatograms.

Björkbom A, Lelyveld VS, Zhang S, Zhang W, Tam CP, Blain JC, Szostak JW.

J Am Chem Soc. 2015 Nov 18;137(45):14430-8. doi: 10.1021/jacs.5b09438. Epub 2015 Nov 9.

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