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Items: 9


Modeling simple repeat expansion diseases with iPSC technology.

Jaworska E, Kozlowska E, Switonski PM, Krzyzosiak WJ.

Cell Mol Life Sci. 2016 Nov;73(21):4085-100. doi: 10.1007/s00018-016-2284-0. Review.


Nuclear speckles are detention centers for transcripts containing expanded CAG repeats.

Urbanek MO, Jazurek M, Switonski PM, Figura G, Krzyzosiak WJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1513-20. doi: 10.1016/j.bbadis.2016.05.015.


Mouse polyQ database: a new online resource for research using mouse models of neurodegenerative diseases.

Szlachcic WJ, Switonski PM, Kurkowiak M, Wiatr K, Figiel M.

Mol Brain. 2015 Oct 29;8(1):69. doi: 10.1186/s13041-015-0160-8.


Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway.

Szlachcic WJ, Switonski PM, Krzyzosiak WJ, Figlerowicz M, Figiel M.

Dis Model Mech. 2015 Sep;8(9):1047-57. doi: 10.1242/dmm.019406.


A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.

Switonski PM, Szlachcic WJ, Krzyzosiak WJ, Figiel M.

Neurobiol Dis. 2015 Jan;73:174-88. doi: 10.1016/j.nbd.2014.09.020.


Mouse models of polyglutamine diseases: review and data table. Part I.

Figiel M, Szlachcic WJ, Switonski PM, Gabka A, Krzyzosiak WJ.

Mol Neurobiol. 2012 Oct;46(2):393-429. doi: 10.1007/s12035-012-8315-4. Review.


Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.

Switonski PM, Szlachcic WJ, Gabka A, Krzyzosiak WJ, Figiel M.

Mol Neurobiol. 2012 Oct;46(2):430-66. doi: 10.1007/s12035-012-8316-3. Review.


An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases.

Fiszer A, Olejniczak M, Switonski PM, Wroblewska JP, Wisniewska-Kruk J, Mykowska A, Krzyzosiak WJ.

BMC Mol Biol. 2012 Mar 7;13:6. doi: 10.1186/1471-2199-13-6.


Mouse ataxin-3 functional knock-out model.

Switonski PM, Fiszer A, Kazmierska K, Kurpisz M, Krzyzosiak WJ, Figiel M.

Neuromolecular Med. 2011 Mar;13(1):54-65. doi: 10.1007/s12017-010-8137-3.

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