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Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.

Huang YA, Zhou B, Nabet AM, Wernig M, Südhof TC.

J Neurosci. 2019 Sep 11;39(37):7408-7427. doi: 10.1523/JNEUROSCI.2994-18.2019. Epub 2019 Jul 22.


Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.

Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC.

J Cell Biol. 2019 Aug 5;218(8):2677-2698. doi: 10.1083/jcb.201812076. Epub 2019 Jul 1.


Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.

Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, Kalani MYS, Südhof TC, Wernig M.

Neuron. 2019 Aug 21;103(4):617-626.e6. doi: 10.1016/j.neuron.2019.05.043. Epub 2019 Jun 27.


SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M.

Neuron. 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002. Epub 2019 Jun 3.


Ablation of All Synaptobrevin vSNAREs Blocks Evoked But Not Spontaneous Neurotransmitter Release at Neuromuscular Synapses.

Liu Y, Sugiura Y, Südhof TC, Lin W.

J Neurosci. 2019 Jul 31;39(31):6049-6066. doi: 10.1523/JNEUROSCI.0403-19.2019. Epub 2019 Jun 3.


Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment.

Gan KJ, Südhof TC.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12524-12533. doi: 10.1073/pnas.1902672116. Epub 2019 Jun 3.


Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.

Chanda S, Ang CE, Lee QY, Ghebrial M, Haag D, Shibuya Y, Wernig M, Südhof TC.

Cell Stem Cell. 2019 Jul 3;25(1):103-119.e6. doi: 10.1016/j.stem.2019.04.021. Epub 2019 May 30.


Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

Dai J, Aoto J, Südhof TC.

Neuron. 2019 Jun 5;102(5):993-1008.e5. doi: 10.1016/j.neuron.2019.03.032. Epub 2019 Apr 17.


Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.

Wu X, Morishita WK, Riley AM, Hale WD, Südhof TC, Malenka RC.

Neuron. 2019 May 8;102(3):621-635.e3. doi: 10.1016/j.neuron.2019.02.013. Epub 2019 Mar 11.


Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity.

Shimojo M, Madara J, Pankow S, Liu X, Yates J 3rd, Südhof TC, Maximov A.

Genes Dev. 2019 Mar 1;33(5-6):365-376. doi: 10.1101/gad.320077.118. Epub 2019 Feb 26.


Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins.

Sando R, Jiang X, Südhof TC.

Science. 2019 Feb 22;363(6429). pii: eaav7969. doi: 10.1126/science.aav7969.


Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning.

Hsu YT, Li J, Wu D, Südhof TC, Chen L.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7113-7122. doi: 10.1073/pnas.1820690116. Epub 2019 Feb 19.


Towards an Understanding of Synapse Formation.

Südhof TC.

Neuron. 2018 Oct 24;100(2):276-293. doi: 10.1016/j.neuron.2018.09.040. Review.


Retinoic Acid Receptor RARα-Dependent Synaptic Signaling Mediates Homeostatic Synaptic Plasticity at the Inhibitory Synapses of Mouse Visual Cortex.

Zhong LR, Chen X, Park E, Südhof TC, Chen L.

J Neurosci. 2018 Dec 5;38(49):10454-10466. doi: 10.1523/JNEUROSCI.1133-18.2018. Epub 2018 Oct 24.


A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory.

Zhou M, Liu Z, Melin MD, Ng YH, Xu W, Südhof TC.

Nat Neurosci. 2018 Nov;21(11):1515-1519. doi: 10.1038/s41593-018-0248-4. Epub 2018 Oct 22.


Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs.

Seigneur E, Polepalli JS, Südhof TC.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10235-E10244. doi: 10.1073/pnas.1811086115. Epub 2018 Oct 4.


The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling.

Zhang Z, Marro SG, Zhang Y, Arendt KL, Patzke C, Zhou B, Fair T, Yang N, Südhof TC, Wernig M, Chen L.

Sci Transl Med. 2018 Aug 1;10(452). pii: eaar4338. doi: 10.1126/scitranslmed.aar4338.


RIM-binding proteins recruit BK-channels to presynaptic release sites adjacent to voltage-gated Ca2+-channels.

Sclip A, Acuna C, Luo F, Südhof TC.

EMBO J. 2018 Aug 15;37(16). pii: e98637. doi: 10.15252/embj.201798637. Epub 2018 Jul 2.


Transdifferentiation of human adult peripheral blood T cells into neurons.

Tanabe K, Ang CE, Chanda S, Olmos VH, Haag D, Levinson DF, Südhof TC, Wernig M.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6470-6475. doi: 10.1073/pnas.1720273115. Epub 2018 Jun 4.


Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons.

Bhouri M, Morishita W, Temkin P, Goswami D, Kawabe H, Brose N, Südhof TC, Craig AM, Siddiqui TJ, Malenka R.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5382-E5389. doi: 10.1073/pnas.1803280115. Epub 2018 May 21.

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