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Items: 1 to 20 of 216


Liquid and Hydrogel Phases of PrPC Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β Oligomers.

Kostylev MA, Tuttle MD, Lee S, Klein LE, Takahashi H, Cox TO, Gunther EC, Zilm KW, Strittmatter SM.

Mol Cell. 2018 Nov 1;72(3):426-443.e12. doi: 10.1016/j.molcel.2018.10.009. Epub 2018 Oct 25.


Diltiazem Promotes Regenerative Axon Growth.

Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ.

Mol Neurobiol. 2018 Sep 19. doi: 10.1007/s12035-018-1349-5. [Epub ahead of print]


Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit.

Dell'Anno MT, Wang X, Onorati M, Li M, Talpo F, Sekine Y, Ma S, Liu F, Cafferty WBJ, Sestan N, Strittmatter SM.

Nat Commun. 2018 Aug 24;9(1):3419. doi: 10.1038/s41467-018-05844-8.


Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576.

Kent BA, Strittmatter SM, Nygaard HB.

J Alzheimers Dis. 2018;64(4):1325-1336. doi: 10.3233/JAD-180260.


Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.

Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM.

Cell Rep. 2018 Jul 3;24(1):269. doi: 10.1016/j.celrep.2018.06.079. No abstract available.


Whole Exome Sequencing of an Exceptional Longevity Cohort.

Nygaard HB, Erson-Omay EZ, Wu X, Kent BA, Bernales CQ, Evans DM, Farrer MJ, Vilariño-Güell C, Strittmatter SM.

J Gerontol A Biol Sci Med Sci. 2018 May 10. doi: 10.1093/gerona/gly098. [Epub ahead of print]


Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.

Sekine Y, Lin-Moore A, Chenette DM, Wang X, Jiang Z, Cafferty WB, Hammarlund M, Strittmatter SM.

Cell Rep. 2018 Apr 10;23(2):415-428. doi: 10.1016/j.celrep.2018.03.058. Erratum in: Cell Rep. 2018 Jul 3;24(1):269.


The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury.

Sekine Y, Siegel CS, Sekine-Konno T, Cafferty WBJ, Strittmatter SM.

Sci Signal. 2018 Apr 3;11(524). pii: eaao4180. doi: 10.1126/scisignal.aao4180.


Synaptotoxic Signaling by Amyloid Beta Oligomers in Alzheimer's Disease Through Prion Protein and mGluR5.

Brody AH, Strittmatter SM.

Adv Pharmacol. 2018;82:293-323. doi: 10.1016/bs.apha.2017.09.007. Epub 2017 Oct 25.


Emerging Mechanisms in Alzheimer's Disease and Their Therapeutic Implications.

Strittmatter SM.

Biol Psychiatry. 2018 Feb 15;83(4):298-299. doi: 10.1016/j.biopsych.2017.12.002. No abstract available.


Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.

Smith LM, Zhu R, Strittmatter SM.

Neuropharmacology. 2018 Mar 1;130:54-61. doi: 10.1016/j.neuropharm.2017.11.042. Epub 2017 Nov 27.


Regulation of axonal regeneration by the level of function of the endogenous Nogo receptor antagonist LOTUS.

Hirokawa T, Zou Y, Kurihara Y, Jiang Z, Sakakibara Y, Ito H, Funakoshi K, Kawahara N, Goshima Y, Strittmatter SM, Takei K.

Sci Rep. 2017 Sep 21;7(1):12119. doi: 10.1038/s41598-017-12449-6.


Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.

Salazar SV, Gallardo C, Kaufman AC, Herber CS, Haas LT, Robinson S, Manson JC, Lee MK, Strittmatter SM.

J Neurosci. 2017 Sep 20;37(38):9207-9221. doi: 10.1523/JNEUROSCI.0722-17.2017. Epub 2017 Aug 21.


Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.

Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM.

Neuron. 2017 Jul 19;95(2):281-296.e6. doi: 10.1016/j.neuron.2017.06.026.


Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.

Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM.

Cell Rep. 2017 Jul 5;20(1):76-88. doi: 10.1016/j.celrep.2017.06.023.


Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.

Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM.

J Neurosci. 2017 Jul 26;37(30):7125-7139. doi: 10.1523/JNEUROSCI.2519-16.2017. Epub 2017 Jun 21.


Identification of Intrinsic Axon Growth Modulators for Intact CNS Neurons after Injury.

Fink KL, López-Giráldez F, Kim IJ, Strittmatter SM, Cafferty WBJ.

Cell Rep. 2017 Mar 14;18(11):2687-2701. doi: 10.1016/j.celrep.2017.02.058.


Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM; Alzheimer’s Disease Neuroimaging Initiative.

Acta Neuropathol. 2017 May;133(5):785-807. doi: 10.1007/s00401-017-1668-z. Epub 2017 Jan 9.


Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury.

Wang X, Sekine Y, Byrne AB, Cafferty WB, Hammarlund M, Strittmatter SM.

eNeuro. 2016 Dec 26;3(6). pii: ENEURO.0270-16.2016. doi: 10.1523/ENEURO.0270-16.2016. eCollection 2016 Nov-Dec.


Rewiring the spinal cord: Direct and indirect strategies.

Dell'Anno MT, Strittmatter SM.

Neurosci Lett. 2017 Jun 23;652:25-34. doi: 10.1016/j.neulet.2016.12.002. Epub 2016 Dec 19. Review.

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