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Items: 1 to 20 of 82

1.

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

Raimondi S, Porcari R, Mangione PP, Verona G, Marcoux J, Giorgetti S, Taylor GW, Ellmerich S, Ballico M, Zanini S, Pardon E, Al-Shawi R, Simons JP, Corazza A, Fogolari F, Leri M, Stefani M, Bucciantini M, Gillmore JD, Hawkins PN, Valli M, Stoppini M, Robinson CV, Steyaert J, Esposito G, Bellotti V.

Sci Rep. 2017 Apr 21;7:46711. doi: 10.1038/srep46711.

2.

Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS.

Natalello A, Mangione PP, Giorgetti S, Porcari R, Marchese L, Zorzoli I, Relini A, Ami D, Faravelli G, Valli M, Stoppini M, Doglia SM, Bellotti V, Raimondi S.

J Biol Chem. 2016 Apr 29;291(18):9678-89. doi: 10.1074/jbc.M116.720573. Epub 2016 Feb 26.

3.

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.

Valleix S, Verona G, Jourde-Chiche N, Nédelec B, Mangione PP, Bridoux F, Mangé A, Dogan A, Goujon JM, Lhomme M, Dauteuille C, Chabert M, Porcari R, Waudby CA, Relini A, Talmud PJ, Kovrov O, Olivecrona G, Stoppini M, Christodoulou J, Hawkins PN, Grateau G, Delpech M, Kontush A, Gillmore JD, Kalopissis AD, Bellotti V.

Nat Commun. 2016 Jan 21;7:10353. doi: 10.1038/ncomms10353.

4.

Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins.

Soria C, Coccini T, De Simone U, Marchese L, Zorzoli I, Giorgetti S, Raimondi S, Mangione PP, Ramat S, Bellotti V, Manzo L, Stoppini M.

Amyloid. 2015;22(4):221-8. doi: 10.3109/13506129.2015.1077216. Epub 2015 Oct 14.

PMID:
26466638
5.

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.

Marcoux J, Mangione PP, Porcari R, Degiacomi MT, Verona G, Taylor GW, Giorgetti S, Raimondi S, Sanglier-Cianférani S, Benesch JL, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Stoppini M, Robinson CV, Pepys MB, Bellotti V.

EMBO Mol Med. 2015 Oct;7(10):1337-49. doi: 10.15252/emmm.201505357.

6.

Systemic amyloidosis: lessons from β2-microglobulin.

Stoppini M, Bellotti V.

J Biol Chem. 2015 Apr 17;290(16):9951-8. doi: 10.1074/jbc.R115.639799. Epub 2015 Mar 6. Review.

7.

Probing the influence of citrate-capped gold nanoparticles on an amyloidogenic protein.

Brancolini G, Corazza A, Vuano M, Fogolari F, Mimmi MC, Bellotti V, Stoppini M, Corni S, Esposito G.

ACS Nano. 2015 Mar 24;9(3):2600-13. doi: 10.1021/nn506161j. Epub 2015 Mar 4.

PMID:
25695203
8.

The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.

Porcari R, Proukakis C, Waudby CA, Bolognesi B, Mangione PP, Paton JF, Mullin S, Cabrita LD, Penco A, Relini A, Verona G, Vendruscolo M, Stoppini M, Tartaglia GG, Camilloni C, Christodoulou J, Schapira AH, Bellotti V.

J Biol Chem. 2015 Jan 23;290(4):2395-404. doi: 10.1074/jbc.M114.610527. Epub 2014 Dec 10.

9.

Rapid proton-detected NMR assignment for proteins with fast magic angle spinning.

Barbet-Massin E, Pell AJ, Retel JS, Andreas LB, Jaudzems K, Franks WT, Nieuwkoop AJ, Hiller M, Higman V, Guerry P, Bertarello A, Knight MJ, Felletti M, Le Marchand T, Kotelovica S, Akopjana I, Tars K, Stoppini M, Bellotti V, Bolognesi M, Ricagno S, Chou JJ, Griffin RG, Oschkinat H, Lesage A, Emsley L, Herrmann T, Pintacuda G.

J Am Chem Soc. 2014 Sep 3;136(35):12489-97. doi: 10.1021/ja507382j. Epub 2014 Aug 18.

10.

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.

Mangione PP, Porcari R, Gillmore JD, Pucci P, Monti M, Porcari M, Giorgetti S, Marchese L, Raimondi S, Serpell LC, Chen W, Relini A, Marcoux J, Clatworthy IR, Taylor GW, Tennent GA, Robinson CV, Hawkins PN, Stoppini M, Wood SP, Pepys MB, Bellotti V.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1539-44. doi: 10.1073/pnas.1317488111. Epub 2014 Jan 13.

11.

Class I major histocompatibility complex, the trojan horse for secretion of amyloidogenic β2-microglobulin.

Halabelian L, Ricagno S, Giorgetti S, Santambrogio C, Barbiroli A, Pellegrino S, Achour A, Grandori R, Marchese L, Raimondi S, Mangione PP, Esposito G, Al-Shawi R, Simons JP, Speck I, Stoppini M, Bolognesi M, Bellotti V.

J Biol Chem. 2014 Feb 7;289(6):3318-27. doi: 10.1074/jbc.M113.524157. Epub 2013 Dec 13.

12.

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: assessment by 15N NMR relaxation.

Gümral D, Fogolari F, Corazza A, Viglino P, Giorgetti S, Stoppini M, Bellotti V, Esposito G.

Magn Reson Chem. 2013 Dec;51(12):795-807. doi: 10.1002/mrc.4018. Epub 2013 Oct 18.

PMID:
24136818
13.

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.

Mangione PP, Esposito G, Relini A, Raimondi S, Porcari R, Giorgetti S, Corazza A, Fogolari F, Penco A, Goto Y, Lee YH, Yagi H, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Chiti F, Rolandi R, Taylor GW, Pepys MB, Stoppini M, Bellotti V.

J Biol Chem. 2013 Oct 25;288(43):30917-30. doi: 10.1074/jbc.M113.498857. Epub 2013 Sep 6.

14.

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

Montagna G, Cazzulani B, Obici L, Uggetti C, Giorgetti S, Porcari R, Ruggiero R, Mangione PP, Brambilla M, Lucchetti J, Guiso G, Gobbi M, Merlini G, Salmona M, Stoppini M, Villa G, Bellotti V.

Amyloid. 2013 Sep;20(3):173-8. doi: 10.3109/13506129.2013.803463. Epub 2013 Jun 4.

PMID:
23734692
15.

Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers.

Esposito G, Garvey M, Alverdi V, Pettirossi F, Corazza A, Fogolari F, Polano M, Mangione PP, Giorgetti S, Stoppini M, Rekas A, Bellotti V, Heck AJ, Carver JA.

J Biol Chem. 2013 Jun 14;288(24):17844-58. doi: 10.1074/jbc.M112.448639. Epub 2013 May 3.

16.

C. elegans expressing human β2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype.

Diomede L, Soria C, Romeo M, Giorgetti S, Marchese L, Mangione PP, Porcari R, Zorzoli I, Salmona M, Bellotti V, Stoppini M.

PLoS One. 2012;7(12):e52314. doi: 10.1371/journal.pone.0052314. Epub 2012 Dec 21.

17.

Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin.

Valleix S, Gillmore JD, Bridoux F, Mangione PP, Dogan A, Nedelec B, Boimard M, Touchard G, Goujon JM, Lacombe C, Lozeron P, Adams D, Lacroix C, Maisonobe T, Planté-Bordeneuve V, Vrana JA, Theis JD, Giorgetti S, Porcari R, Ricagno S, Bolognesi M, Stoppini M, Delpech M, Pepys MB, Hawkins PN, Bellotti V.

N Engl J Med. 2012 Jun 14;366(24):2276-83. doi: 10.1056/NEJMoa1201356.

18.

Single-shot NMR measurement of protein unfolding landscapes.

Rennella E, Corazza A, Codutti L, Causero A, Bellotti V, Stoppini M, Viglino P, Fogolari F, Esposito G.

Biochim Biophys Acta. 2012 Jun;1824(6):842-9. doi: 10.1016/j.bbapap.2012.04.002. Epub 2012 Apr 13.

PMID:
22522028
19.

Determining the energy landscape of proteins by a fast isotope exchange NMR approach.

Rennella E, Corazza A, Codutti L, Bellotti V, Stoppini M, Viglino P, Fogolari F, Esposito G.

J Am Chem Soc. 2012 Mar 14;134(10):4457-60. doi: 10.1021/ja209004q. Epub 2012 Mar 5.

PMID:
22380530
20.

Fibrillogenesis of human β2 -microglobulin in three-dimensional silicon microstructures.

Merlo S, Barillaro G, Carpignano F, Silva G, Surdo S, Strambini LM, Giorgetti S, Nichino D, Relini A, Mazzini G, Stoppini M, Bellotti V.

J Biophotonics. 2012 Oct;5(10):785-92. doi: 10.1002/jbio.201100132. Epub 2012 Jan 23.

PMID:
22271711

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