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The cytotoxic T lymphocyte immune synapse at a glance.

Dieckmann NM, Frazer GL, Asano Y, Stinchcombe JC, Griffiths GM.

J Cell Sci. 2016 Aug 1;129(15):2881-6. doi: 10.1242/jcs.186205. Review.


Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.

Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM.

Curr Biol. 2015 Dec 21;25(24):3239-44. doi: 10.1016/j.cub.2015.10.028. Epub 2015 Dec 5.


Actin depletion initiates events leading to granule secretion at the immunological synapse.

Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM.

Immunity. 2015 May 19;42(5):864-76. doi: 10.1016/j.immuni.2015.04.013.


Communication, the centrosome and the immunological synapse.

Stinchcombe JC, Griffiths GM.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130463. doi: 10.1098/rstb.2013.0463. Review.


Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.

Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM.

Elife. 2014 Mar 4;3:e01310. doi: 10.7554/eLife.01310.


Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation.

Lui-Roberts WW, Stinchcombe JC, Ritter AT, Akhmanova A, Karakesisoglou I, Griffiths GM.

Eur J Immunol. 2012 Aug;42(8):2132-41. doi: 10.1002/eji.201242525.


Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.

Stinchcombe JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM.

BMC Biol. 2011 Jun 28;9:45. doi: 10.1186/1741-7007-9-45.


Centrosome docking at the immunological synapse is controlled by Lck signaling.

Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.

J Cell Biol. 2011 Feb 21;192(4):663-74. doi: 10.1083/jcb.201008140.


The immunological synapse: a focal point for endocytosis and exocytosis.

Griffiths GM, Tsun A, Stinchcombe JC.

J Cell Biol. 2010 May 3;189(3):399-406. doi: 10.1083/jcb.201002027. Review.


The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.

Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM.

Immunity. 2009 Oct 16;31(4):621-31. doi: 10.1016/j.immuni.2009.08.024.


Secretory mechanisms in cell-mediated cytotoxicity.

Stinchcombe JC, Griffiths GM.

Annu Rev Cell Dev Biol. 2007;23:495-517. Review.


Centrosome polarization delivers secretory granules to the immunological synapse.

Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM.

Nature. 2006 Sep 28;443(7110):462-5. Erratum in: Nature. 2006 Nov 9;444(7116):236.


Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis.

Santoro A, Cannella S, Bossi G, Gallo F, Trizzino A, Pende D, Dieli F, Bruno G, Stinchcombe JC, Micalizzi C, De Fusco C, Danesino C, Moretta L, Notarangelo LD, Griffiths GM, Aricò M.

J Med Genet. 2006 Dec;43(12):953-60. Epub 2006 Jul 6.


The role of the secretory immunological synapse in killing by CD8+ CTL.

Stinchcombe JC, Griffiths GM.

Semin Immunol. 2003 Dec;15(6):301-5. Review.


Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse.

Clark RH, Stinchcombe JC, Day A, Blott E, Booth S, Bossi G, Hamblin T, Davies EG, Griffiths GM.

Nat Immunol. 2003 Nov;4(11):1111-20. Epub 2003 Oct 19.


Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.

Igakura T, Stinchcombe JC, Goon PK, Taylor GP, Weber JN, Griffiths GM, Tanaka Y, Osame M, Bangham CR.

Science. 2003 Mar 14;299(5613):1713-6. Epub 2003 Feb 13.


The immunological synapse of CTL contains a secretory domain and membrane bridges.

Stinchcombe JC, Bossi G, Booth S, Griffiths GM.

Immunity. 2001 Nov;15(5):751-61.


Normal and abnormal secretion by haemopoietic cells.

Stinchcombe JC, Griffiths GM.

Immunology. 2001 May;103(1):10-6. Review.


Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

Stinchcombe JC, Barral DC, Mules EH, Booth S, Hume AN, Machesky LM, Seabra MC, Griffiths GM.

J Cell Biol. 2001 Feb 19;152(4):825-34.

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