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Items: 1 to 20 of 267

1.

Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity.

Shrestha R, Garrett SC, Almo SC, Fiser A.

Structure. 2019 May 7;27(5):829-836.e3. doi: 10.1016/j.str.2019.03.006. Epub 2019 Mar 28.

PMID:
30930066
2.

GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells.

Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, Ng KY, Ghoddusi M, Purdon TJ, Wang X, Do T, Pham MT, Brown JM, De Larrea CF, Olson E, Peguero E, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Wendel HG, Riviere I, Liu C, Sather B, Brentjens RJ.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau7746. doi: 10.1126/scitranslmed.aau7746.

PMID:
30918115
3.

Genetically modified hematopoietic stem/progenitor cells that produce IL-10-secreting regulatory T cells.

Ng SL, Leno-Duran E, Samanta D, Almo SC, Strominger JL.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2634-2639. doi: 10.1073/pnas.1811984116. Epub 2019 Jan 25.

PMID:
30683721
4.

Substrate Profile of the Phosphotriesterase Homology Protein from Escherichia coli.

Nemmara VV, Xiang DF, Fedorov AA, Fedorov EV, Bonanno JB, Almo SC, Raushel FM.

Biochemistry. 2018 Oct 30;57(43):6219-6227. doi: 10.1021/acs.biochem.8b00935. Epub 2018 Oct 16.

PMID:
30277746
5.

Novel Metabolic Pathways and Regulons for Hexuronate Utilization in Proteobacteria.

Bouvier JT, Sernova NV, Ghasempur S, Rodionova IA, Vetting MW, Al-Obaidi NF, Almo SC, Gerlt JA, Rodionov DA.

J Bacteriol. 2018 Dec 20;201(2). pii: e00431-18. doi: 10.1128/JB.00431-18. Print 2019 Jan 15.

PMID:
30249705
6.

Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine.

Ryu H, Grove TL, Almo SC, Kim J.

Nucleic Acids Res. 2018 Sep 28;46(17):9160-9169. doi: 10.1093/nar/gky592.

7.

Publisher Correction: A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Oct;562(7725):E3. doi: 10.1038/s41586-018-0355-0.

PMID:
29980769
8.

A naturally occurring antiviral ribonucleotide encoded by the human genome.

Gizzi AS, Grove TL, Arnold JJ, Jose J, Jangra RK, Garforth SJ, Du Q, Cahill SM, Dulyaninova NG, Love JD, Chandran K, Bresnick AR, Cameron CE, Almo SC.

Nature. 2018 Jun;558(7711):610-614. doi: 10.1038/s41586-018-0238-4. Epub 2018 Jun 20. Erratum in: Nature. 2018 Oct;562(7725):E3.

9.

Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells That Enhance Protective Immunity in Tuberculosis.

Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR Jr, Sette A, Almo SC, Porcelli SA.

Infect Immun. 2018 Aug 22;86(9). pii: e00009-18. doi: 10.1128/IAI.00009-18. Print 2018 Sep.

10.

Functional assignment of multiple catabolic pathways for D-apiose.

Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA.

Nat Chem Biol. 2018 Jul;14(7):696-705. doi: 10.1038/s41589-018-0067-7. Epub 2018 Jun 4.

11.

Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Relatives.

Odokonyero D, McMillan AW, Ramagopal UA, Toro R, Truong DP, Zhu M, Lopez MS, Somiari B, Herman M, Aziz A, Bonanno JB, Hull KG, Burley SK, Romo D, Almo SC, Glasner ME.

Biochemistry. 2018 Jul 3;57(26):3676-3689. doi: 10.1021/acs.biochem.8b00088. Epub 2018 May 30.

PMID:
29767960
12.

Development and Evaluation of an Optimal Human Single-Chain Variable Fragment-Derived BCMA-Targeted CAR T Cell Vector.

Smith EL, Staehr M, Masakayan R, Tatake IJ, Purdon TJ, Wang X, Wang P, Liu H, Xu Y, Garrett-Thomson SC, Almo SC, Riviere I, Liu C, Brentjens RJ.

Mol Ther. 2018 Jun 6;26(6):1447-1456. doi: 10.1016/j.ymthe.2018.03.016. Epub 2018 Mar 28.

PMID:
29678657
13.

Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.

14.

The biosynthesis of methanobactin.

Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM Jr, Krebs C, Kelleher NL, Rosenzweig AC.

Science. 2018 Mar 23;359(6382):1411-1416. doi: 10.1126/science.aap9437.

15.

X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.

Barr I, Stich TA, Gizzi AS, Grove TL, Bonanno JB, Latham JA, Chung T, Wilmot CM, Britt RD, Almo SC, Klinman JP.

Biochemistry. 2018 Feb 27;57(8):1306-1315. doi: 10.1021/acs.biochem.7b01097. Epub 2018 Feb 6.

16.

Prediction of enzymatic pathways by integrative pathway mapping.

Calhoun S, Korczynska M, Wichelecki DJ, San Francisco B, Zhao S, Rodionov DA, Vetting MW, Al-Obaidi NF, Lin H, O'Meara MJ, Scott DA, Morris JH, Russel D, Almo SC, Osterman AL, Gerlt JA, Jacobson MP, Shoichet BK, Sali A.

Elife. 2018 Jan 29;7. pii: e31097. doi: 10.7554/eLife.31097.

17.

Mechanism and Structure of γ-Resorcylate Decarboxylase.

Sheng X, Patskovsky Y, Vladimirova A, Bonanno JB, Almo SC, Himo F, Raushel FM.

Biochemistry. 2018 Jun 5;57(22):3167-3175. doi: 10.1021/acs.biochem.7b01213. Epub 2018 Jan 19.

PMID:
29283551
18.

Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.

Ghosh A, Ramagopal UA, Bonanno JB, Brenowitz M, Almo SC.

Biochemistry. 2018 Feb 27;57(8):1293-1305. doi: 10.1021/acs.biochem.7b01074. Epub 2018 Feb 7.

PMID:
29261291
19.

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells.

Ohaegbulam KC, Liu W, Jeon H, Almo SC, Zang X.

Oncotarget. 2017 Sep 20;8(47):82740-82753. doi: 10.18632/oncotarget.21098. eCollection 2017 Oct 10.

20.

General principles of binding between cell surface receptors and multi-specific ligands: A computational study.

Chen J, Almo SC, Wu Y.

PLoS Comput Biol. 2017 Oct 10;13(10):e1005805. doi: 10.1371/journal.pcbi.1005805. eCollection 2017 Oct.

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