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Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu.

Chen X, Jin DY, Stafford DW, Tie JK.

Blood. 2018 Nov 1;132(18):1974-1984. doi: 10.1182/blood-2018-05-846592. Epub 2018 Aug 8.


Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition.

Wu S, Chen X, Jin DY, Stafford DW, Pedersen LG, Tie JK.

Blood. 2018 Aug 9;132(6):647-657. doi: 10.1182/blood-2018-01-830901. Epub 2018 May 9.


Vitamin K epoxide reductase and its paralogous enzyme have different structures and functions.

Sinhadri BCS, Jin DY, Stafford DW, Tie JK.

Sci Rep. 2017 Dec 15;7(1):17632. doi: 10.1038/s41598-017-18008-3.


Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors.

Jin DY, Ingram BO, Stafford DW, Tie JK.

Blood. 2017 Aug 17;130(7):948-951. doi: 10.1182/blood-2017-05-782367. Epub 2017 Jul 5. No abstract available.


Functional Study of the Vitamin K Cycle Enzymes in Live Cells.

Tie JK, Stafford DW.

Methods Enzymol. 2017;584:349-394. doi: 10.1016/bs.mie.2016.10.015. Epub 2016 Nov 22.


Splice-Site Mutation of Exon 3 Deletion in the Gamma-Glutamyl Carboxylase Gene Causes Inactivation of the Enzyme.

Jin DY, Vermeer C, Stafford DW, Tie JK.

J Invest Dermatol. 2016 Nov;136(11):2314-2317. doi: 10.1016/j.jid.2016.05.128. Epub 2016 Jul 6. No abstract available.


Extravascular FIX and coagulation.

Stafford DW.

Thromb J. 2016 Oct 4;14(Suppl 1):35. eCollection 2016. Review.


Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice.

Cooley B, Funkhouser W, Monroe D, Ezzell A, Mann DM, Lin FC, Monahan PE, Stafford DW.

Blood. 2016 Jul 14;128(2):286-92. doi: 10.1182/blood-2016-01-696104. Epub 2016 Apr 22.


Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders.

Tie JK, Carneiro JD, Jin DY, Martinhago CD, Vermeer C, Stafford DW.

Blood. 2016 Apr 14;127(15):1847-55. doi: 10.1182/blood-2015-10-677633. Epub 2016 Jan 12.


Structural and functional insights into enzymes of the vitamin K cycle.

Tie JK, Stafford DW.

J Thromb Haemost. 2016 Feb;14(2):236-47. doi: 10.1111/jth.13217. Epub 2016 Jan 29. Review.


Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial.

Monahan PE, Sun J, Gui T, Hu G, Hannah WB, Wichlan DG, Wu Z, Grieger JC, Li C, Suwanmanee T, Stafford DW, Booth CJ, Samulski JJ, Kafri T, McPhee SW, Samulski RJ.

Hum Gene Ther. 2015 Feb;26(2):69-81. doi: 10.1089/hum.2014.106. Epub 2015 Jan 21.


Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.

Tie JK, Jin DY, Stafford DW.

J Biol Chem. 2014 Mar 28;289(13):9396-407. doi: 10.1074/jbc.M113.534446. Epub 2014 Feb 13.


A conformational investigation of propeptide binding to the integral membrane protein ╬│-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry.

Parker CH, Morgan CR, Rand KD, Engen JR, Jorgenson JW, Stafford DW.

Biochemistry. 2014 Mar 11;53(9):1511-20. doi: 10.1021/bi401536m. Epub 2014 Feb 26.


FVIIa as used pharmacologically is not TF dependent in hemophilia B mice.

Feng D, Whinna H, Monroe D, Stafford DW.

Blood. 2014 Mar 13;123(11):1764-6. doi: 10.1182/blood-2013-08-522987. Epub 2014 Jan 14.


Membrane topology for human vitamin K epoxide reductase.

Wu S, Tie JK, Stafford DW, Pedersen LG.

J Thromb Haemost. 2014 Jan;12(1):112-4. doi: 10.1111/jth.12450. No abstract available.


Evidence of clinically significant extravascular stores of factor IX.

Feng D, Stafford KA, Broze GJ, Stafford DW.

J Thromb Haemost. 2013 Dec;11(12):2176-8. doi: 10.1111/jth.12421. No abstract available.


Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice.

Ingram BO, Turbyfill JL, Bledsoe PJ, Jaiswal AK, Stafford DW.

Biochem J. 2013 Nov 15;456(1):47-54. doi: 10.1042/BJ20130639.


Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms.

Tie JK, Jin DY, Stafford DW.

J Biol Chem. 2012 Oct 5;287(41):33945-55. doi: 10.1074/jbc.M112.402941. Epub 2012 Aug 24.


Mycobacterium tuberculosis vitamin K epoxide reductase homologue supports vitamin K-dependent carboxylation in mammalian cells.

Tie JK, Jin DY, Stafford DW.

Antioxid Redox Signal. 2012 Feb 15;16(4):329-38. doi: 10.1089/ars.2011.4043. Epub 2011 Nov 22.

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