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Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial.

Dandona P, Mathieu C, Phillip M, Hansen L, Griffen SC, Tschöpe D, Thorén F, Xu J, Langkilde AM; DEPICT-1 Investigators.

Lancet Diabetes Endocrinol. 2017 Nov;5(11):864-876. doi: 10.1016/S2213-8587(17)30308-X. Epub 2017 Sep 14. Erratum in: Lancet Diabetes Endocrinol. 2017 Dec;5(12 ):e8.


Implications from distinct sulfate-reducing bacteria populations between cattle manure and digestate in the elucidation of H2S production during anaerobic digestion of animal slurry.

St-Pierre B, Wright AG.

Appl Microbiol Biotechnol. 2017 Jul;101(13):5543-5556. doi: 10.1007/s00253-017-8261-1. Epub 2017 Apr 7.


Virus-induced gene silencing of the two squalene synthase isoforms of apple tree (Malus × domestica L.) negatively impacts phytosterol biosynthesis, plastid pigmentation and leaf growth.

Navarro Gallón SM, Elejalde-Palmett C, Daudu D, Liesecke F, Jullien F, Papon N, Dugé de Bernonville T, Courdavault V, Lanoue A, Oudin A, Glévarec G, Pichon O, Clastre M, St-Pierre B, Atehortùa L, Yoshikawa N, Giglioli-Guivarc'h N, Besseau S.

Planta. 2017 Jul;246(1):45-60. doi: 10.1007/s00425-017-2681-0. Epub 2017 Mar 27.


Virus-induced gene silencing in Rauwolfia species.

Corbin C, Lafontaine F, Sepúlveda LJ, Carqueijeiro I, Courtois M, Lanoue A, Dugé de Bernonville T, Besseau S, Glévarec G, Papon N, Atehortúa L, Giglioli-Guivarc'h N, Clastre M, St-Pierre B, Oudin A, Courdavault V.

Protoplasma. 2017 Jul;254(4):1813-1818. doi: 10.1007/s00709-017-1079-y. Epub 2017 Jan 24.


Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses.

Dugé de Bernonville T, Carqueijeiro I, Lanoue A, Lafontaine F, Sánchez Bel P, Liesecke F, Musset K, Oudin A, Glévarec G, Pichon O, Besseau S, Clastre M, St-Pierre B, Flors V, Maury S, Huguet E, O'Connor SE, Courdavault V.

Sci Rep. 2017 Jan 17;7:40453. doi: 10.1038/srep40453.


Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

Parage C, Foureau E, Kellner F, Burlat V, Mahroug S, Lanoue A, Dugé de Bernonville T, Londono MA, Carqueijeiro I, Oudin A, Besseau S, Papon N, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, Clastre M, O'Connor SE, Courdavault V.

Plant Physiol. 2016 Nov;172(3):1563-1577. Epub 2016 Sep 29.


Prequels to Synthetic Biology: From Candidate Gene Identification and Validation to Enzyme Subcellular Localization in Plant and Yeast Cells.

Foureau E, Carqueijeiro I, Dugé de Bernonville T, Melin C, Lafontaine F, Besseau S, Lanoue A, Papon N, Oudin A, Glévarec G, Clastre M, St-Pierre B, Giglioli-Guivarc'h N, Courdavault V.

Methods Enzymol. 2016;576:167-206. doi: 10.1016/bs.mie.2016.02.013. Epub 2016 Mar 23.


In a Neonatal Piglet Model of Intestinal Failure, Administration of Antibiotics and Lack of Enteral Nutrition Have a Greater Impact on Intestinal Microflora Than Surgical Resection Alone.

Levesque CL, Turner J, Li J, Wizzard P, St Pierre B, Lim D, Wales P.

JPEN J Parenter Enteral Nutr. 2017 Aug;41(6):938-945. doi: 10.1177/0148607115626903. Epub 2016 Feb 2.


Characterization of a spermidine hydroxycinnamoyltransferase in Malus domestica highlights the evolutionary conservation of trihydroxycinnamoyl spermidines in pollen coat of core Eudicotyledons.

Elejalde-Palmett C, de Bernonville TD, Glevarec G, Pichon O, Papon N, Courdavault V, St-Pierre B, Giglioli-Guivarc'h N, Lanoue A, Besseau S.

J Exp Bot. 2015 Dec;66(22):7271-85. doi: 10.1093/jxb/erv423. Epub 2015 Sep 12.


Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome.

Dugé de Bernonville T, Foureau E, Parage C, Lanoue A, Clastre M, Londono MA, Oudin A, Houillé B, Papon N, Besseau S, Glévarec G, Atehortùa L, Giglioli-Guivarc'h N, St-Pierre B, De Luca V, O'Connor SE, Courdavault V.

BMC Genomics. 2015 Aug 19;16:619. doi: 10.1186/s12864-015-1678-y.


Toward the identification of methanogenic archaeal groups as targets of methane mitigation in livestock animalsr.

St-Pierre B, Cersosimo LM, Ishaq SL, Wright AD.

Front Microbiol. 2015 Jul 30;6:776. doi: 10.3389/fmicb.2015.00776. eCollection 2015. Review.


Examination of the rumen bacteria and methanogenic archaea of wild impalas (Aepyceros melampus melampus) from Pongola, South Africa.

Cersosimo LM, Lachance H, St-Pierre B, van Hoven W, Wright AD.

Microb Ecol. 2015 Apr;69(3):577-85. doi: 10.1007/s00248-014-0521-3. Epub 2014 Oct 29.


Follow-up of blood-pressure lowering and glucose control in type 2 diabetes.

Zoungas S, Chalmers J, Neal B, Billot L, Li Q, Hirakawa Y, Arima H, Monaghan H, Joshi R, Colagiuri S, Cooper ME, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Lisheng L, Mancia G, Marre M, Matthews DR, Mogensen CE, Perkovic V, Poulter N, Rodgers A, Williams B, MacMahon S, Patel A, Woodward M; ADVANCE-ON Collaborative Group.

N Engl J Med. 2014 Oct 9;371(15):1392-406. doi: 10.1056/NEJMoa1407963. Epub 2014 Sep 19.


Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine.

Dugé de Bernonville T, Clastre M, Besseau S, Oudin A, Burlat V, Glévarec G, Lanoue A, Papon N, Giglioli-Guivarc'h N, St-Pierre B, Courdavault V.

Phytochemistry. 2015 May;113:9-23. doi: 10.1016/j.phytochem.2014.07.023. Epub 2014 Aug 18. Review.


ZCT1 and ZCT2 transcription factors repress the activity of a gene promoter from the methyl erythritol phosphate pathway in Madagascar periwinkle cells.

Chebbi M, Ginis O, Courdavault V, Glévarec G, Lanoue A, Clastre M, Papon N, Gaillard C, Atanassova R, St-Pierre B, Giglioli-Guivarc'h N, Courtois M, Oudin A.

J Plant Physiol. 2014 Oct 15;171(16):1510-3. doi: 10.1016/j.jplph.2014.07.004. Epub 2014 Jul 23.


A look inside an alkaloid multisite plant: the Catharanthus logistics.

Courdavault V, Papon N, Clastre M, Giglioli-Guivarc'h N, St-Pierre B, Burlat V.

Curr Opin Plant Biol. 2014 Jun;19:43-50. doi: 10.1016/j.pbi.2014.03.010. Epub 2014 Apr 13. Review.


A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus.

Besseau S, Kellner F, Lanoue A, Thamm AM, Salim V, Schneider B, Geu-Flores F, Höfer R, Guirimand G, Guihur A, Oudin A, Glevarec G, Foureau E, Papon N, Clastre M, Giglioli-Guivarc'h N, St-Pierre B, Werck-Reichhart D, Burlat V, De Luca V, O'Connor SE, Courdavault V.

Plant Physiol. 2013 Dec;163(4):1792-803. doi: 10.1104/pp.113.222828. Epub 2013 Oct 9.


Comparative metagenomic analysis of bacterial populations in three full-scale mesophilic anaerobic manure digesters.

St-Pierre B, Wright AD.

Appl Microbiol Biotechnol. 2014 Mar;98(6):2709-17. doi: 10.1007/s00253-013-5220-3. Epub 2013 Oct 2.


Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.

Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I; SAVOR-TIMI 53 Steering Committee and Investigators.

N Engl J Med. 2013 Oct 3;369(14):1317-26. doi: 10.1056/NEJMoa1307684. Epub 2013 Sep 2.

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