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Items: 1 to 20 of 117

1.

Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.

To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT.

Carcinogenesis. 2015 Jul;36(7):769-81. doi: 10.1093/carcin/bgv061.

2.

Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ.

J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064.

3.

A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer.

So JY, Lin JJ, Wahler J, Liby KT, Sporn MB, Suh N.

PLoS One. 2014 Sep 17;9(9):e107616. doi: 10.1371/journal.pone.0107616.

4.

Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.

Choi SH, Kim BG, Robinson J, Fink S, Yan M, Sporn MB, Markowitz SD, Letterio JJ.

J Clin Invest. 2014 Jun;124(6):2472-82. doi: 10.1172/JCI69672.

5.

The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice.

To C, Kim EH, Royce DB, Williams CR, Collins RM, Risingsong R, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2014 Jul;7(7):698-707. doi: 10.1158/1940-6207.CAPR-14-0047.

6.

Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.

Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD.

Cancer Prev Res (Phila). 2014 Jul;7(7):658-65. doi: 10.1158/1940-6207.CAPR-13-0430.

7.

Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.

So JY, Wahler JE, Yoon T, Smolarek AK, Lin Y, Shih WJ, Maehr H, Uskokovic M, Liby KT, Sporn MB, Suh N.

Cancer Prev Res (Phila). 2013 Sep;6(9):959-70. doi: 10.1158/1940-6207.CAPR-13-0087.

8.

NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury.

Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH.

J Immunol. 2013 Feb 15;190(4):1714-24. doi: 10.4049/jimmunol.1202410.

9.

ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J.

Cancer Res. 2013 Jan 15;73(2):1020-30. doi: 10.1158/0008-5472.CAN-12-2862.

10.

The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.

Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT.

Carcinogenesis. 2013 Jan;34(1):199-210. doi: 10.1093/carcin/bgs319.

11.
12.

NRF2 and cancer: the good, the bad and the importance of context.

Sporn MB, Liby KT.

Nat Rev Cancer. 2012 Jul 19;12(8):564-71. doi: 10.1038/nrc3278.

13.

Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.

Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B.

Antioxid Redox Signal. 2013 Jan 10;18(2):139-57. doi: 10.1089/ars.2011.4491.

14.

Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury.

Zhang F, Wang S, Zhang M, Weng Z, Li P, Gan Y, Zhang L, Cao G, Gao Y, Leak RK, Sporn MB, Chen J.

Stroke. 2012 May;43(5):1390-7. doi: 10.1161/STROKEAHA.111.647420.

15.

Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis.

Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, Sporn MB, Letterio JJ.

Sci Rep. 2011;1:201. doi: 10.1038/srep00201.

16.

CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.

Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT.

Cancer Prev Res (Phila). 2012 Jan;5(1):89-97. doi: 10.1158/1940-6207.CAPR-11-0359.

17.

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice.

Lu T, Ramakrishnan R, Altiok S, Youn JI, Cheng P, Celis E, Pisarev V, Sherman S, Sporn MB, Gabrilovich D.

J Clin Invest. 2011 Oct;121(10):4015-29. doi: 10.1172/JCI45862.

18.

Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT.

PLoS One. 2011;6(7):e22862. doi: 10.1371/journal.pone.0022862.

19.

Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury.

Wei Y, Gong J, Yoshida T, Eberhart CG, Xu Z, Kombairaju P, Sporn MB, Handa JT, Duh EJ.

Free Radic Biol Med. 2011 Jul 1;51(1):216-24. doi: 10.1016/j.freeradbiomed.2011.04.026.

20.

CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells.

Kim EH, Deng CX, Sporn MB, Liby KT.

Cancer Prev Res (Phila). 2011 Mar;4(3):425-34. doi: 10.1158/1940-6207.CAPR-10-0153.

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