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Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice.

Spindler SR, Mote PL, Flegal JM.

Age (Dordr). 2016 Dec;38(5-6):379-391. doi: 10.1007/s11357-016-9948-4. Epub 2016 Sep 2.


MicroRNAs Circulate in the Hemolymph of Drosophila and Accumulate Relative to Tissue microRNAs in an Age-Dependent Manner.

Dhahbi JM, Atamna H, Li R, Yamakawa A, Guerrero N, Lam HT, Mote P, Spindler SR.

Genomics Insights. 2016 Mar 28;9:29-39. doi: 10.4137/GEI.S38147. eCollection 2016.


Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.

Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM.

Mol Cell Biol. 2015 Oct;35(20):3471-90. doi: 10.1128/MCB.00030-15. Epub 2015 Aug 3.


Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse.

Victoria B, Dhahbi JM, Nunez Lopez YO, Spinel L, Atamna H, Spindler SR, Masternak MM.

Aging Cell. 2015 Dec;14(6):1055-66. doi: 10.1111/acel.12373. Epub 2015 Jul 14.


Circulating small non-coding RNA signature in head and neck squamous cell carcinoma.

Victoria Martinez B, Dhahbi JM, Nunez Lopez YO, Lamperska K, Golusinski P, Luczewski L, Kolenda T, Atamna H, Spindler SR, Golusinski W, Masternak MM.

Oncotarget. 2015 Aug 7;6(22):19246-63.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.


Deep Sequencing of Serum Small RNAs Identifies Patterns of 5' tRNA Half and YRNA Fragment Expression Associated with Breast Cancer.

Dhahbi JM, Spindler SR, Atamna H, Boffelli D, Martin DI.

Biomark Cancer. 2014 Dec 8;6:37-47. doi: 10.4137/BIC.S20764. eCollection 2014.


Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice.

Spindler SR, Mote PL, Lublin AL, Flegal JM, Dhahbi JM, Li R.

J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1479-89. doi: 10.1093/gerona/glu190. Epub 2014 Nov 7.


Dietary supplementation with Lovaza and krill oil shortens the life span of long-lived F1 mice.

Spindler SR, Mote PL, Flegal JM.

Age (Dordr). 2014 Jun;36(3):9659. doi: 10.1007/s11357-014-9659-7. Epub 2014 May 10.


Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice.

Spindler SR, Mote PL, Flegal JM.

Age (Dordr). 2014 Apr;36(2):705-18. doi: 10.1007/s11357-013-9609-9. Epub 2013 Dec 28.


Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.

Wu Y, Lin JC, Piluso LG, Dhahbi JM, Bobadilla S, Spindler SR, Liu X.

Mol Cell. 2014 Jan 9;53(1):63-74. doi: 10.1016/j.molcel.2013.10.031. Epub 2013 Nov 27.


5'-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma.

Dhahbi JM, Spindler SR, Atamna H, Boffelli D, Mote P, Martin DI.

Physiol Genomics. 2013 Nov 1;45(21):990-8. doi: 10.1152/physiolgenomics.00129.2013. Epub 2013 Sep 10.


Metformin improves healthspan and lifespan in mice.

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R.

Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192.


5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction.

Dhahbi JM, Spindler SR, Atamna H, Yamakawa A, Boffelli D, Mote P, Martin DI.

BMC Genomics. 2013 May 2;14:298. doi: 10.1186/1471-2164-14-298.


Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction.

Dhahbi JM, Spindler SR, Atamna H, Yamakawa A, Guerrero N, Boffelli D, Mote P, Martin DI.

Aging (Albany NY). 2013 Feb;5(2):130-41.


β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice.

Spindler SR, Mote PL, Li R, Dhahbi JM, Yamakawa A, Flegal JM, Jeske DR, Li R, Lublin AL.

Age (Dordr). 2013 Dec;35(6):2099-109. doi: 10.1007/s11357-012-9498-3. Epub 2013 Jan 15.


Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.

Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams RT, Wang Y, Ablao KP.

PLoS One. 2012;7(6):e39581. doi: 10.1371/journal.pone.0039581. Epub 2012 Jun 21.


Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.

Spindler SR, Li R, Dhahbi JM, Yamakawa A, Sauer F.

PLoS One. 2012;7(2):e29782. doi: 10.1371/journal.pone.0029782. Epub 2012 Feb 20.


mRNA-Seq reveals complex patterns of gene regulation and expression in the mouse skeletal muscle transcriptome associated with calorie restriction.

Dhahbi JM, Atamna H, Boffelli D, Martin DI, Spindler SR.

Physiol Genomics. 2012 Mar 19;44(6):331-44. doi: 10.1152/physiolgenomics.00129.2011. Epub 2012 Jan 24.

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