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Items: 1 to 20 of 104


High-Dimensional Profiling for Computational Diagnosis.

Lottaz C, Gronwald W, Spang R, Engelmann JC.

Methods Mol Biol. 2017;1526:205-229.


Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis.

Feist M, Kemper J, Taruttis F, Rehberg T, Engelmann JC, Gronwald W, Hummel M, Spang R, Kube D.

Int J Cancer. 2016 Sep 26. doi: 10.1002/ijc.30444. [Epub ahead of print]


Reference point insensitive molecular data analysis.

Altenbuchinger M, Rehberg T, Zacharias HU, Stämmler F, Dettmer K, Weber D, Hiergeist A, Gessner A, Holler E, Oefner PJ, Spang R.

Bioinformatics. 2016 Sep 15. pii: btw598. [Epub ahead of print]


Adjusting microbiome profiles for differences in microbial load by spike-in bacteria.

Stämmler F, Gläsner J, Hiergeist A, Holler E, Weber D, Oefner PJ, Gessner A, Spang R.

Microbiome. 2016 Jun 21;4(1):28. doi: 10.1186/s40168-016-0175-0.


Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients.

Teufel A, Itzel T, Erhart W, Brosch M, Wang XY, Kim YO, von Schönfels W, Herrmann A, Brückner S, Stickel F, Dufour JF, Chavakis T, Hellerbrand C, Spang R, Maass T, Becker T, Schreiber S, Schafmayer C, Schuppan D, Hampe J.

Gastroenterology. 2016 Sep;151(3):513-525.e0. doi: 10.1053/j.gastro.2016.05.051.


Refining Pathways: A Model Comparison Approach.

Moffa G, Erdmann G, Voloshanenko O, Hundsrucker C, Sadeh MJ, Boutros M, Spang R.

PLoS One. 2016 Jun 1;11(6):e0155999. doi: 10.1371/journal.pone.0155999.


Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data.

Schrader A, Meyer K, Walther N, Stolz A, Feist M, Hand E, von Bonin F, Evers M, Kohler C, Shirneshan K, Vockerodt M, Klapper W, Szczepanowski M, Murray PG, Bastians H, Trümper L, Spang R, Kube D.

Oncotarget. 2016 Jul 26;7(30):47061-47081. doi: 10.18632/oncotarget.9219.


Validation Study: Response-Predictive Gene Expression Profiling of Glioma Progenitor Cells In Vitro.

Moeckel S, Vollmann-Zwerenz A, Proescholdt M, Brawanski A, Riemenschneider MJ, Bogdahn U, Bosserhoff AK, Spang R, Hau P.

PLoS One. 2016 Mar 15;11(3):e0151312. doi: 10.1371/journal.pone.0151312.


Analyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models.

Pirkl M, Hand E, Kube D, Spang R.

Bioinformatics. 2016 Mar 15;32(6):893-900. doi: 10.1093/bioinformatics/btv680.


A statistical approach to virtual cellular experiments: improved causal discovery using accumulation IDA (aIDA).

Taruttis F, Spang R, Engelmann JC.

Bioinformatics. 2015 Dec 1;31(23):3807-14. doi: 10.1093/bioinformatics/btv461.


Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue.

Masqué-Soler N, Szczepanowski M, Kohler CW, Aukema SM, Nagel I, Richter J, Siebert R, Spang R, Burkhardt B, Klapper W.

Br J Haematol. 2015 Nov;171(4):501-8. doi: 10.1111/bjh.13624.


Low urinary indoxyl sulfate levels early after transplantation reflect a disrupted microbiome and are associated with poor outcome.

Weber D, Oefner PJ, Hiergeist A, Koestler J, Gessner A, Weber M, Hahn J, Wolff D, Stämmler F, Spang R, Herr W, Dettmer K, Holler E.

Blood. 2015 Oct 1;126(14):1723-8. doi: 10.1182/blood-2015-04-638858.


The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.

Wagener R, Aukema SM, Schlesner M, Haake A, Burkhardt B, Claviez A, Drexler HG, Hummel M, Kreuz M, Loeffler M, Rosolowski M, López C, Möller P, Richter J, Rohde M, Betts MJ, Russell RB, Bernhart SH, Hoffmann S, Rosenstiel P, Schilhabel M, Szczepanowski M, Trümper L, Klapper W, Siebert R; ICGC MMML-Seq-Project.; "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe..

Genes Chromosomes Cancer. 2015 Sep;54(9):555-64. doi: 10.1002/gcc.22268.


Data Normalization of (1)H NMR Metabolite Fingerprinting Data Sets in the Presence of Unbalanced Metabolite Regulation.

Hochrein J, Zacharias HU, Taruttis F, Samol C, Engelmann JC, Spang R, Oefner PJ, Gronwald W.

J Proteome Res. 2015 Aug 7;14(8):3217-28. doi: 10.1021/acs.jproteome.5b00192.


Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma.

Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, Thasler WE, Kristl T, Teufel A, Huber CG, Oefner PJ, Spang R, Hellerbrand C.

PLoS Comput Biol. 2015 May 28;11(5):e1004293. doi: 10.1371/journal.pcbi.1004293.


Response-predictive gene expression profiling of glioma progenitor cells in vitro.

Moeckel S, Meyer K, Leukel P, Heudorfer F, Seliger C, Stangl C, Bogdahn U, Proescholdt M, Brawanski A, Vollmann-Zwerenz A, Riemenschneider MJ, Bosserhoff AK, Spang R, Hau P.

PLoS One. 2014 Sep 30;9(9):e108632. doi: 10.1371/journal.pone.0108632.


ACGME Duty Hour Requirements: Perceptions and Impact on Resident Training and Patient Care.

Levine WN, Spang RC 3rd.

J Am Acad Orthop Surg. 2014 Sep;22(9):535-44. doi: 10.5435/JAAOS-22-09-535.


siPools: highly complex but accurately defined siRNA pools eliminate off-target effects.

Hannus M, Beitzinger M, Engelmann JC, Weickert MT, Spang R, Hannus S, Meister G.

Nucleic Acids Res. 2014 Jul;42(12):8049-61. doi: 10.1093/nar/gku480.


Increased expression of c-Jun in nonalcoholic fatty liver disease.

Dorn C, Engelmann JC, Saugspier M, Koch A, Hartmann A, Müller M, Spang R, Bosserhoff A, Hellerbrand C.

Lab Invest. 2014 Apr;94(4):394-408. doi: 10.1038/labinvest.2014.3.


Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease.

Holler E, Butzhammer P, Schmid K, Hundsrucker C, Koestler J, Peter K, Zhu W, Sporrer D, Hehlgans T, Kreutz M, Holler B, Wolff D, Edinger M, Andreesen R, Levine JE, Ferrara JL, Gessner A, Spang R, Oefner PJ.

Biol Blood Marrow Transplant. 2014 May;20(5):640-5. doi: 10.1016/j.bbmt.2014.01.030.

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