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Persistent lymphopenia is a risk factor for ICU-acquired infections and for death in ICU patients with sustained hypotension at admission.

Adrie C, Lugosi M, Sonneville R, Souweine B, Ruckly S, Cartier JC, Garrouste-Orgeas M, Schwebel C, Timsit JF; OUTCOMEREA study group..

Ann Intensive Care. 2017 Dec;7(1):30. doi: 10.1186/s13613-017-0242-0. Epub 2017 Mar 17.


Attributable mortality of ICU-acquired bloodstream infections: Impact of the source, causative micro-organism, resistance profile and antimicrobial therapy.

Adrie C, Garrouste-Orgeas M, Ibn Essaied W, Schwebel C, Darmon M, Mourvillier B, Ruckly S, Dumenil AS, Kallel H, Argaud L, Marcotte G, Barbier F, Laurent V, Goldgran-Toledano D, Clec'h C, Azoulay E, Souweine B, Timsit JF; OUTCOMEREA Study Group*..

J Infect. 2017 Feb;74(2):131-141. doi: 10.1016/j.jinf.2016.11.001. Epub 2016 Nov 9.


Treatment intensity and outcome of nonagenarians selected for admission in ICUs: a multicenter study of the Outcomerea Research Group.

Garrouste-Orgeas M, Ruckly S, Grégoire C, Dumesnil AS, Pommier C, Jamali S, Golgran-Toledano D, Schwebel C, Clec'h C, Soufir L, Fartoukh M, Marcotte G, Argaud L, Verdière B, Darmon M, Azoulay E, Timsit JF.

Ann Intensive Care. 2016 Dec;6(1):31. doi: 10.1186/s13613-016-0133-9. Epub 2016 Apr 14.


Colonization and infection with extended-spectrum β-lactamase-producing Enterobacteriaceae in ICU patients: what impact on outcomes and carbapenem exposure?

Barbier F, Pommier C, Essaied W, Garrouste-Orgeas M, Schwebel C, Ruckly S, Dumenil AS, Lemiale V, Mourvillier B, Clec'h C, Darmon M, Laurent V, Marcotte G, Lucet JC, Souweine B, Zahar JR, Timsit JF; OUTCOMEREA Study Group..

J Antimicrob Chemother. 2016 Apr;71(4):1088-97. doi: 10.1093/jac/dkv423. Epub 2016 Jan 10.


Respective impact of no escalation of treatment, withholding and withdrawal of life-sustaining treatment on ICU patients' prognosis: a multicenter study of the Outcomerea Research Group.

Lautrette A, Garrouste-Orgeas M, Bertrand PM, Goldgran-Toledano D, Jamali S, Laurent V, Argaud L, Schwebel C, Mourvillier B, Darmon M, Ruckly S, Dumenil AS, Lemiale V, Souweine B, Timsit JF; Outcomerea Study Group..

Intensive Care Med. 2015 Oct;41(10):1763-72. doi: 10.1007/s00134-015-3944-5. Epub 2015 Jul 7.


Impact of early nutrition and feeding route on outcomes of mechanically ventilated patients with shock: a post hoc marginal structural model study.

Reignier J, Darmon M, Sonneville R, Borel AL, Garrouste-Orgeas M, Ruckly S, Souweine B, Dumenil AS, Haouache H, Adrie C, Argaud L, Soufir L, Marcotte G, Laurent V, Goldgran-Toledano D, Clec'h C, Schwebel C, Azoulay E, Timsit JF; OutcomeRea Network..

Intensive Care Med. 2015 May;41(5):875-86. doi: 10.1007/s00134-015-3730-4. Epub 2015 Mar 20.


The Iatroref study: medical errors are associated with symptoms of depression in ICU staff but not burnout or safety culture.

Garrouste-Orgeas M, Perrin M, Soufir L, Vesin A, Blot F, Maxime V, Beuret P, Troché G, Klouche K, Argaud L, Azoulay E, Timsit JF.

Intensive Care Med. 2015 Feb;41(2):273-84. doi: 10.1007/s00134-014-3601-4. Epub 2015 Jan 10.


Noninvasive mechanical ventilation in acute respiratory failure: trends in use and outcomes.

Schnell D, Timsit JF, Darmon M, Vesin A, Goldgran-Toledano D, Dumenil AS, Garrouste-Orgeas M, Adrie C, Bouadma L, Planquette B, Cohen Y, Schwebel C, Soufir L, Jamali S, Souweine B, Azoulay E.

Intensive Care Med. 2014 Apr;40(4):582-91. doi: 10.1007/s00134-014-3222-y. Epub 2014 Feb 7.


Safety of intrahospital transport in ventilated critically ill patients: a multicenter cohort study*.

Schwebel C, Clec'h C, Magne S, Minet C, Garrouste-Orgeas M, Bonadona A, Dumenil AS, Jamali S, Kallel H, Goldgran-Toledano D, Marcotte G, Azoulay E, Darmon M, Ruckly S, Souweine B, Timsit JF; OUTCOMEREA Study Group..

Crit Care Med. 2013 Aug;41(8):1919-28. doi: 10.1097/CCM.0b013e31828a3bbd.


Pseudomonas aeruginosa ventilator-associated pneumonia. predictive factors of treatment failure.

Planquette B, Timsit JF, Misset BY, Schwebel C, Azoulay E, Adrie C, Vesin A, Jamali S, Zahar JR, Allaouchiche B, Souweine B, Darmon M, Dumenil AS, Goldgran-Toledano D, Mourvillier BH, Bédos JP; OUTCOMEREA Study Group..

Am J Respir Crit Care Med. 2013 Jul 1;188(1):69-76. doi: 10.1164/rccm.201210-1897OC.


Management of thrombocytopenia in the ICU (pregnancy excluded).

Van der Linden T, Souweine B, Dupic L, Soufir L, Meyer P.

Ann Intensive Care. 2012 Aug 28;2(1):42. doi: 10.1186/2110-5820-2-42.


Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: implications for emergency surgery and resuscitation.

Lillo-Le Louët A, Wolf M, Soufir L, Galbois A, Dumenil AS, Offenstadt G, Samama MM.

Thromb Haemost. 2012 Sep;108(3):583-5. doi: 10.1160/TH12-03-0149. Epub 2012 Jul 10. No abstract available.


A model to predict short-term death or readmission after intensive care unit discharge.

Ouanes I, Schwebel C, Français A, Bruel C, Philippart F, Vesin A, Soufir L, Adrie C, Garrouste-Orgeas M, Timsit JF, Misset B; Outcomerea Study Group..

J Crit Care. 2012 Aug;27(4):422.e1-9. doi: 10.1016/j.jcrc.2011.08.003. Epub 2011 Dec 14.


A multifaceted program for improving quality of care in intensive care units: IATROREF study.

Garrouste-Orgeas M, Soufir L, Tabah A, Schwebel C, Vesin A, Adrie C, Thuong M, Timsit JF; Outcomerea Study Group..

Crit Care Med. 2012 Feb;40(2):468-76. doi: 10.1097/CCM.0b013e318232d94d.


Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis.

Bekaert M, Timsit JF, Vansteelandt S, Depuydt P, Vésin A, Garrouste-Orgeas M, Decruyenaere J, Clec'h C, Azoulay E, Benoit D; Outcomerea Study Group..

Am J Respir Crit Care Med. 2011 Nov 15;184(10):1133-9. doi: 10.1164/rccm.201105-0867OC.


Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa.

Kaminski C, Timsit JF, Dubois Y, Zahar JR, Garrouste-Orgeas M, Vesin A, Azoulay E, Feger C, Dumenil AS, Adrie C, Cohen Y, Allaouchiche B; OUTCOMEREA study group..

Crit Care. 2011;15(2):R112. doi: 10.1186/cc10136. Epub 2011 Apr 11.


[Anaesthesia in elderly people].

Laurent V, Abback PS, Christian P, Obiang N, Soufir L, Rouquette-Vincenti I.

Soins Gerontol. 2011 Jan-Feb;(87):29-32. French.


Selected medical errors in the intensive care unit: results of the IATROREF study: parts I and II.

Garrouste-Orgeas M, Timsit JF, Vesin A, Schwebel C, Arnodo P, Lefrant JY, Souweine B, Tabah A, Charpentier J, Gontier O, Fieux F, Mourvillier B, Troché G, Reignier J, Dumay MF, Azoulay E, Reignier B, Carlet J, Soufir L; OUTCOMEREA Study Group..

Am J Respir Crit Care Med. 2010 Jan 15;181(2):134-42. doi: 10.1164/rccm.200812-1820OC. Epub 2009 Oct 29.


Study of prone positioning to reduce ventilator-associated pneumonia in hypoxaemic patients.

Mounier R, Adrie C, Français A, Garrouste-Orgeas M, Cheval C, Allaouchiche B, Jamali S, Dinh-Xuan AT, Goldgran-Toledano D, Cohen Y, Azoulay E, Timsit JF, Ricard JD; OUTCOMEREA Study Group..

Eur Respir J. 2010 Apr;35(4):795-804. doi: 10.1183/09031936.00057509. Epub 2009 Sep 9.


[Field 2. Epidemiology (medical errors and patient adverse events). French-speaking Society of Intensive Care. French Society of Anesthesia and Resuscitation].

Soufir L, Auroy Y.

Ann Fr Anesth Reanim. 2008 Oct;27(10):e59-63. doi: 10.1016/j.annfar.2008.09.008. Epub 2008 Oct 31. French.


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