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Items: 1 to 20 of 142


c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.

Badger J, Grover P, Shi H, Panjarian SB, Engen JR, Smithgall TE, Makowski L.

Biochemistry. 2016 Jun 14;55(23):3251-60. doi: 10.1021/acs.biochem.6b00202.


Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.

Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR.

J Am Soc Mass Spectrom. 2016 Jun;27(6):1048-61. doi: 10.1007/s13361-016-1365-5.


Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.

Emert-Sedlak LA, Loughran HM, Shi H, Kulp JL 3rd, Shu ST, Zhao J, Day BW, Wrobel JE, Reitz AB, Smithgall TE.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1480-4. doi: 10.1016/j.bmcl.2016.01.043.


Dynamics of the Tec-family tyrosine kinase SH3 domains.

Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE.

Protein Sci. 2016 Apr;25(4):852-64. doi: 10.1002/pro.2887.


Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.

Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR.

Biochemistry. 2015 Oct 20;54(41):6382-91. doi: 10.1021/acs.biochem.5b00875.


MCPIP1 Endoribonuclease Activity Negatively Regulates Interleukin-17-Mediated Signaling and Inflammation.

Garg AV, Amatya N, Chen K, Cruz JA, Grover P, Whibley N, Conti HR, Hernandez Mir G, Sirakova T, Childs EC, Smithgall TE, Biswas PS, Kolls JK, McGeachy MJ, Kolattukudy PE, Gaffen SL.

Immunity. 2015 Sep 15;43(3):475-87. doi: 10.1016/j.immuni.2015.07.021.


Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function.

Grover P, Shi H, Baumgartner M, Camacho CJ, Smithgall TE.

PLoS One. 2015 Jul 29;10(7):e0133590. doi: 10.1371/journal.pone.0133590.


Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.

Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR.

Anal Chem. 2015 Jul 21;87(14):7030-5. doi: 10.1021/acs.analchem.5b01725.


A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.

Moroco JA, Baumgartner MP, Rust HL, Choi HG, Hur W, Gray NS, Camacho CJ, Smithgall TE.

Chem Biol Drug Des. 2015 Aug;86(2):144-55. doi: 10.1111/cbdd.12473.


Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.

Zhang X, Simerly C, Hartnett C, Schatten G, Smithgall TE.

Stem Cell Res. 2014 Nov;13(3 Pt A):379-89. doi: 10.1016/j.scr.2014.09.007.


Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE.

PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629.


Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.

Alvarado JJ, Tarafdar S, Yeh JI, Smithgall TE.

J Biol Chem. 2014 Oct 10;289(41):28539-53. doi: 10.1074/jbc.M114.600031.


Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle JP, Coyne CB, Sadovsky Y.

Am J Obstet Gynecol. 2015 Jan;212(1):71.e1-8. doi: 10.1016/j.ajog.2014.07.060.


The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.

Tarafdar S, Poe JA, Smithgall TE.

J Biol Chem. 2014 May 30;289(22):15718-28. doi: 10.1074/jbc.M114.572099.


Synthesis and structure-activity analysis of diphenylpyrazolodiazene inhibitors of the HIV-1 Nef virulence factor.

Iyer PC, Zhao J, Emert-Sedlak LA, Moore KK, Smithgall TE, Day BW.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1702-6. doi: 10.1016/j.bmcl.2014.02.045.


Small molecule inhibitors of the HIV-1 virulence factor, Nef.

Smithgall TE, Thomas G.

Drug Discov Today Technol. 2013 Dec;10(4):e523-9. doi: 10.1016/j.ddtec.2013.07.002. Review.


Development and validation of a high-content bimolecular fluorescence complementation assay for small-molecule inhibitors of HIV-1 Nef dimerization.

Poe JA, Vollmer L, Vogt A, Smithgall TE.

J Biomol Screen. 2014 Apr;19(4):556-65. doi: 10.1177/1087057113513640.


Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen.

Trible RP, Narute P, Emert-Sedlak LA, Alvarado JJ, Atkins K, Thomas L, Kodama T, Yanamala N, Korotchenko V, Day BW, Thomas G, Smithgall TE.

Retrovirology. 2013 Nov 14;10:135. doi: 10.1186/1742-4690-10-135.


Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.

Perrone R, Nadai M, Poe JA, Frasson I, Palumbo M, Pal├╣ G, Smithgall TE, Richter SN.

PLoS One. 2013 Aug 27;8(8):e73121. doi: 10.1371/journal.pone.0073121.

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