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Items: 1 to 20 of 29


Evolutionary history of Tibetans inferred from whole-genome sequencing.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD.

PLoS Genet. 2017 Apr 27;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr.


Oxygen transport adaptations to exercise in native highland populations.

Simonson TS, Wagner PD.

Exp Physiol. 2015 Nov;100(11):1231-2. doi: 10.1113/EP085073. No abstract available.


Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.

Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde LB.

Exp Physiol. 2015 Nov;100(11):1263-8. doi: 10.1113/EP085035. Review.


Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m.

Wagner PD, Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Ge RL.

Exp Physiol. 2015 Nov;100(11):1256-62. doi: 10.1113/EP085036. Review.


Altitude Adaptation: A Glimpse Through Various Lenses.

Simonson TS.

High Alt Med Biol. 2015 Jun;16(2):125-37. doi: 10.1089/ham.2015.0033. Review.


Metabolic aspects of high-altitude adaptation in Tibetans.

Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA.

Exp Physiol. 2015 Nov;100(11):1247-55. doi: 10.1113/EP085292. Epub 2015 Jul 14. Review.


Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity.

Simonson TS, Wei G, Wagner HE, Wuren T, Qin G, Yan M, Wagner PD, Ge RL.

J Physiol. 2015 Jul 15;593(14):3207-18. doi: 10.1113/JP270518. Epub 2015 Jun 25. Erratum in: J Physiol. 2016 Feb 1;594(3):797.


Reply: To PMID 25172885.

Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL.

Exp Physiol. 2015 Mar;100(3):342. doi: 10.1113/EP085032. No abstract available.


Increased blood-oxygen binding affinity in Tibetan and Han Chinese residents at 4200 m.

Simonson TS, Wei G, Wagner HE, Wuren T, Bui A, Fine JM, Qin G, Beltrami FG, Yan M, Wagner PD, Ge RL.

Exp Physiol. 2014 Dec 1;99(12):1624-35. doi: 10.1113/expphysiol.2014.080820. Epub 2014 Aug 28.


A genetic mechanism for Tibetan high-altitude adaptation.

Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT.

Nat Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067. Epub 2014 Aug 17.


Shared and unique signals of high-altitude adaptation in geographically distinct Tibetan populations.

Wuren T, Simonson TS, Qin G, Xing J, Huff CD, Witherspoon DJ, Jorde LB, Ge RL.

PLoS One. 2014 Mar 18;9(3):e88252. doi: 10.1371/journal.pone.0088252. eCollection 2014.


Less is more: blunted responses to hypoxia revealed in sea-level Tibetans.

Simonson TS, Powell FL.

J Appl Physiol (1985). 2014 Apr 1;116(7):711-2. doi: 10.1152/japplphysiol.01110.2013. Epub 2013 Oct 10. No abstract available.


Genomic analysis of natural selection and phenotypic variation in high-altitude mongolians.

Xing J, Wuren T, Simonson TS, Watkins WS, Witherspoon DJ, Wu W, Qin G, Huff CD, Jorde LB, Ge RL.

PLoS Genet. 2013;9(7):e1003634. doi: 10.1371/journal.pgen.1003634. Epub 2013 Jul 18.


Metabolic insight into mechanisms of high-altitude adaptation in Tibetans.

Ge RL, Simonson TS, Cooksey RC, Tanna U, Qin G, Huff CD, Witherspoon DJ, Xing J, Zhengzhong B, Prchal JT, Jorde LB, McClain DA.

Mol Genet Metab. 2012 Jun;106(2):244-7. doi: 10.1016/j.ymgme.2012.03.003. Epub 2012 Mar 17.


Genetic determinants of Tibetan high-altitude adaptation.

Simonson TS, McClain DA, Jorde LB, Prchal JT.

Hum Genet. 2012 Apr;131(4):527-33. doi: 10.1007/s00439-011-1109-3. Epub 2011 Nov 9. Review.


Crohn's disease and genetic hitchhiking at IBD5.

Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL.

Mol Biol Evol. 2012 Jan;29(1):101-11. doi: 10.1093/molbev/msr151. Epub 2011 Aug 4.


Maximum-likelihood estimation of recent shared ancestry (ERSA).

Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB.

Genome Res. 2011 May;21(5):768-74. doi: 10.1101/gr.115972.110. Epub 2011 Feb 8.


Ancestry of the Iban is predominantly Southeast Asian: genetic evidence from autosomal, mitochondrial, and Y chromosomes.

Simonson TS, Xing J, Barrett R, Jerah E, Loa P, Zhang Y, Watkins WS, Witherspoon DJ, Huff CD, Woodward S, Mowry B, Jorde LB.

PLoS One. 2011 Jan 31;6(1):e16338. doi: 10.1371/journal.pone.0016338.


Toward a more uniform sampling of human genetic diversity: a survey of worldwide populations by high-density genotyping.

Xing J, Watkins WS, Shlien A, Walker E, Huff CD, Witherspoon DJ, Zhang Y, Simonson TS, Weiss RB, Schiffman JD, Malkin D, Woodward SR, Jorde LB.

Genomics. 2010 Oct;96(4):199-210. doi: 10.1016/j.ygeno.2010.07.004. Epub 2010 Jul 16.


Genetic evidence for high-altitude adaptation in Tibet.

Simonson TS, Yang Y, Huff CD, Yun H, Qin G, Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, Prchal JT, Ge R.

Science. 2010 Jul 2;329(5987):72-5. doi: 10.1126/science.1189406. Epub 2010 May 13.

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