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Aubergine iCLIP Reveals piRNA-Dependent Decay of mRNAs Involved in Germ Cell Development in the Early Embryo.

Barckmann B, Pierson S, Dufourt J, Papin C, Armenise C, Port F, Grentzinger T, Chambeyron S, Baronian G, Desvignes JP, Curk T, Simonelig M.

Cell Rep. 2015 Aug 18;12(7):1205-16. doi: 10.1016/j.celrep.2015.07.030.


Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis.

Chartier A, Klein P, Pierson S, Barbezier N, Gidaro T, Casas F, Carberry S, Dowling P, Maynadier L, Bellec M, Oloko M, Jardel C, Moritz B, Dickson G, Mouly V, Ohlendieck K, Butler-Browne G, Trollet C, Simonelig M.

PLoS Genet. 2015 Mar 27;11(3):e1005092. doi: 10.1371/journal.pgen.1005092.


piRNAs, master regulators of gene expression.

Simonelig M.

Cell Res. 2014 Jul;24(7):779-80. doi: 10.1038/cr.2014.78.


Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects.

Temme C, Simonelig M, Wahle E.

Front Genet. 2014 May 26;5:143. doi: 10.3389/fgene.2014.00143. Review.


The CCR4 deadenylase acts with Nanos and Pumilio in the fine-tuning of Mei-P26 expression to promote germline stem cell self-renewal.

Joly W, Chartier A, Rojas-Rios P, Busseau I, Simonelig M.

Stem Cell Reports. 2013 Nov 7;1(5):411-24. doi: 10.1016/j.stemcr.2013.09.007.


PABPN1 shuts down alternative poly(A) sites.

Simonelig M.

Cell Res. 2012 Oct;22(10):1419-21. doi: 10.1038/cr.2012.86.


Maternal-to-zygotic transition: soma versus germline.

Simonelig M.

Genome Biol. 2012 Feb 22;13(2):145. doi: 10.1186/gb-2012-13-2-145.


Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients.

Anvar SY, 't Hoen PA, Venema A, van der Sluijs B, van Engelen B, Snoeck M, Vissing J, Trollet C, Dickson G, Chartier A, Simonelig M, van Ommen GJ, van der Maarel SM, Raz V.

Skelet Muscle. 2011 Apr 4;1(1):15. doi: 10.1186/2044-5040-1-15.


Developmental functions of piRNAs and transposable elements: a Drosophila point-of-view.

Simonelig M.

RNA Biol. 2011 Sep-Oct;8(5):754-9. doi: 10.4161/rna.8.5.16042.


Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy.

Barbezier N, Chartier A, Bidet Y, Buttstedt A, Voisset C, Galons H, Blondel M, Schwarz E, Simonelig M.

EMBO Mol Med. 2011 Jan;3(1):35-49. doi: 10.1002/emmm.201000109.


Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo.

Rouget C, Papin C, Boureux A, Meunier AC, Franco B, Robine N, Lai EC, Pelisson A, Simonelig M.

Nature. 2010 Oct 28;467(7319):1128-32. doi: 10.1038/nature09465.


Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.

Temme C, Zhang L, Kremmer E, Ihling C, Chartier A, Sinz A, Simonelig M, Wahle E.

RNA. 2010 Jul;16(7):1356-70. doi: 10.1261/rna.2145110.


A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1.

Chartier A, Benoit B, Simonelig M.

EMBO J. 2006 May 17;25(10):2253-62.


A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila.

Temme C, Zaessinger S, Meyer S, Simonelig M, Wahle E.

EMBO J. 2004 Jul 21;23(14):2862-71.


Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila.

Juge F, Zaessinger S, Temme C, Wahle E, Simonelig M.

EMBO J. 2002 Dec 2;21(23):6603-13.


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