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Items: 9


The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.

Li M, de Graaf IA, Siissalo S, de Jager MH, van Dam A, Groothuis GM.

Drug Metab Dispos. 2016 May;44(5):683-91. doi: 10.1124/dmd.115.068684. Epub 2016 Mar 1.


Nanoparticle formulation of a poorly soluble cannabinoid receptor 1 antagonist improves absorption by rat and human intestine.

Siissalo S, de Waard H, de Jager MH, Hayeshi R, Frijlink HW, Hinrichs WL, Dinter-Heidorn H, van Dam A, Proost JH, Groothuis GM, de Graaf IA.

Drug Metab Dispos. 2013 Aug;41(8):1557-65. doi: 10.1124/dmd.112.049585. Epub 2013 Jun 3.


Defining new criteria for selection of cell-based intestinal models using publicly available databases.

Christensen J, El-Gebali S, Natoli M, Sengstag T, Delorenzi M, Bentz S, Bouzourene H, Rumbo M, Felsani A, Siissalo S, Hirvonen J, Vila MR, Saletti P, Aguet M, Anderle P.

BMC Genomics. 2012 Jun 22;13:274. doi: 10.1186/1471-2164-13-274.


In vitro methods to study the interplay of drug metabolism and efflux in the intestine.

Siissalo S, Heikkinen AT.

Curr Drug Metab. 2013 Jan;14(1):102-11. Review.


Transport of the coumarin metabolite 7-hydroxycoumarin glucuronide is mediated via multidrug resistance-associated proteins 3 and 4.

Wittgen HG, van den Heuvel JJ, van den Broek PH, Siissalo S, Groothuis GM, de Graaf IA, Koenderink JB, Russel FG.

Drug Metab Dispos. 2012 Jun;40(6):1076-9. doi: 10.1124/dmd.111.044438. Epub 2012 Mar 12.


Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol.

Siissalo S, Laine L, Tolonen A, Kaukonen AM, Finel M, Hirvonen J.

Int J Pharm. 2010 Jan 4;383(1-2):24-9. doi: 10.1016/j.ijpharm.2009.08.044. Epub 2009 Sep 4.


A Caco-2 cell based screening method for compounds interacting with MRP2 efflux protein.

Siissalo S, Hannukainen J, Kolehmainen J, Hirvonen J, Kaukonen AM.

Eur J Pharm Biopharm. 2009 Feb;71(2):332-8. doi: 10.1016/j.ejpb.2008.08.010. Epub 2008 Aug 19.


The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells.

Siissalo S, Zhang H, Stilgenbauer E, Kaukonen AM, Hirvonen J, Finel M.

Drug Metab Dispos. 2008 Nov;36(11):2331-6. doi: 10.1124/dmd.108.022335. Epub 2008 Aug 11.


Effect of cell differentiation and passage number on the expression of efflux proteins in wild type and vinblastine-induced Caco-2 cell lines.

Siissalo S, Laitinen L, Koljonen M, Vellonen KS, Kortejärvi H, Urtti A, Hirvonen J, Kaukonen AM.

Eur J Pharm Biopharm. 2007 Sep;67(2):548-54. Epub 2007 Mar 28.


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