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Items: 10


CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.

Zaghloul EM, Gissberg O, Moreno PMD, Siggens L, Hällbrink M, Jørgensen AS, Ekwall K, Zain R, Wengel J, Lundin KE, Smith CIE.

Nucleic Acids Res. 2017 May 19;45(9):5153-5169. doi: 10.1093/nar/gkx111.


Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia.

Qu Y, Siggens L, Cordeddu L, Gaidzik VI, Karlsson K, Bullinger L, Döhner K, Ekwall K, Lehmann S, Lennartsson A.

Blood. 2017 Feb 16;129(7):e13-e25. doi: 10.1182/blood-2016-07-726877. Epub 2016 Dec 21.


Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions.

Siggens L, Cordeddu L, Rönnerblad M, Lennartsson A, Ekwall K.

Epigenetics Chromatin. 2015 Jan 15;8(1):4. doi: 10.1186/1756-8935-8-4. eCollection 2015.


Epigenetics, chromatin and genome organization: recent advances from the ENCODE project.

Siggens L, Ekwall K.

J Intern Med. 2014 Sep;276(3):201-14. doi: 10.1111/joim.12231. Epub 2014 Mar 27. Review.


Centromeric histone H2B monoubiquitination promotes noncoding transcription and chromatin integrity.

Sadeghi L, Siggens L, Svensson JP, Ekwall K.

Nat Struct Mol Biol. 2014 Mar;21(3):236-43. doi: 10.1038/nsmb.2776. Epub 2014 Feb 16.


The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation.

Fernandez-Twinn DS, Blackmore HL, Siggens L, Giussani DA, Cross CM, Foo R, Ozanne SE.

Endocrinology. 2012 Dec;153(12):5961-71. doi: 10.1210/en.2012-1508. Epub 2012 Oct 15.


The landscape of DNA repeat elements in human heart failure.

Haider S, Cordeddu L, Robinson E, Movassagh M, Siggens L, Vujic A, Choy MK, Goddard M, Lio P, Foo R.

Genome Biol. 2012 Oct 3;13(10):R90. doi: 10.1186/gb-2012-13-10-r90.


Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1.

Siggens L, Figg N, Bennett M, Foo R.

FASEB J. 2012 May;26(5):2117-24. doi: 10.1096/fj.11-197525. Epub 2012 Feb 1.


Distinct epigenomic features in end-stage failing human hearts.

Movassagh M, Choy MK, Knowles DA, Cordeddu L, Haider S, Down T, Siggens L, Vujic A, Simeoni I, Penkett C, Goddard M, Lio P, Bennett MR, Foo RS.

Circulation. 2011 Nov 29;124(22):2411-22. doi: 10.1161/CIRCULATIONAHA.111.040071. Epub 2011 Oct 24.


High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure.

Choy MK, Movassagh M, Siggens L, Vujic A, Goddard M, Sánchez A, Perkins N, Figg N, Bennett M, Carroll J, Foo R.

Genome Med. 2010 Jun 14;2(6):37. doi: 10.1186/gm158.

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