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Items: 1 to 20 of 32


Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells.

Wilkinson EL, Sidaway JE, Cross MJ.

J Cell Physiol. 2018 Jan;233(1):186-200. doi: 10.1002/jcp.26064. Epub 2017 Aug 3.


Application of 1H NMR spectroscopy to the metabolic phenotyping of rodent brain extracts: A metabonomic study of gut microbial influence on host brain metabolism.

Swann JR, Garcia-Perez I, Braniste V, Wilson ID, Sidaway JE, Nicholson JK, Pettersson S, Holmes E.

J Pharm Biomed Anal. 2017 Sep 5;143:141-146. doi: 10.1016/j.jpba.2017.05.040. Epub 2017 May 31.


Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.

Carr DF, Ayehunie S, Davies A, Duckworth CA, French S, Hall N, Hussain S, Mellor HR, Norris A, Park BK, Penrose A, Pritchard DM, Probert CS, Ramaiah S, Sadler C, Schmitt M, Shaw A, Sidaway JE, Vries RG, Wagoner M, Pirmohamed M.

Pharmacol Ther. 2017 Apr;172:181-194. doi: 10.1016/j.pharmthera.2017.01.002. Epub 2017 Jan 27. Review.


Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues.

Ravenscroft SM, Pointon A, Williams AW, Cross MJ, Sidaway JE.

Toxicol Sci. 2016 Jul;152(1):99-112. doi: 10.1093/toxsci/kfw069. Epub 2016 Apr 28.


MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

Kia R, Kelly L, Sison-Young RL, Zhang F, Pridgeon CS, Heslop JA, Metcalfe P, Kitteringham NR, Baxter M, Harrison S, Hanley NA, Burke ZD, Storm MP, Welham MJ, Tosh D, Küppers-Munther B, Edsbagge J, Starkey Lewis PJ, Bonner F, Harpur E, Sidaway J, Bowes J, Fenwick SW, Malik H, Goldring CE, Park BK.

Toxicol Sci. 2015 Mar;144(1):173-85. doi: 10.1093/toxsci/kfu269. Epub 2014 Dec 18.


Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury.

Cross MJ, Berridge BR, Clements PJ, Cove-Smith L, Force TL, Hoffmann P, Holbrook M, Lyon AR, Mellor HR, Norris AA, Pirmohamed M, Tugwood JD, Sidaway JE, Park BK.

Br J Pharmacol. 2015 Feb;172(4):957-74. doi: 10.1111/bph.12979. Epub 2015 Jan 12. Review.


Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat.

Gan XT, Ettinger G, Huang CX, Burton JP, Haist JV, Rajapurohitam V, Sidaway JE, Martin G, Gloor GB, Swann JR, Reid G, Karmazyn M.

Circ Heart Fail. 2014 May;7(3):491-9. doi: 10.1161/CIRCHEARTFAILURE.113.000978. Epub 2014 Mar 13.


Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1.

Armstrong D, Summers C, Ewart L, Nylander S, Sidaway JE, van Giezen JJ.

J Cardiovasc Pharmacol Ther. 2014 Mar;19(2):209-19. doi: 10.1177/1074248413511693. Epub 2014 Jan 10.


Safety pharmacology--current and emerging concepts.

Hamdam J, Sethu S, Smith T, Alfirevic A, Alhaidari M, Atkinson J, Ayala M, Box H, Cross M, Delaunois A, Dermody A, Govindappa K, Guillon JM, Jenkins R, Kenna G, Lemmer B, Meecham K, Olayanju A, Pestel S, Rothfuss A, Sidaway J, Sison-Young R, Smith E, Stebbings R, Tingle Y, Valentin JP, Williams A, Williams D, Park K, Goldring C.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):229-41. doi: 10.1016/j.taap.2013.04.039. Epub 2013 Jun 1. Review.


Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity.

Pointon A, Abi-Gerges N, Cross MJ, Sidaway JE.

Toxicol Sci. 2013 Apr;132(2):317-26. doi: 10.1093/toxsci/kft005. Epub 2013 Jan 12.


Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.

Mallinson JE, Constantin-Teodosiu D, Glaves PD, Martin EA, Davies WJ, Westwood FR, Sidaway JE, Greenhaff PL.

J Physiol. 2012 Dec 15;590(24):6389-402. doi: 10.1113/jphysiol.2012.238022. Epub 2012 Oct 8.


Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model.

van Giezen JJ, Sidaway J, Glaves P, Kirk I, Björkman JA.

J Cardiovasc Pharmacol Ther. 2012 Jun;17(2):164-72. doi: 10.1177/1074248411410883. Epub 2011 Jun 22.


Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats.

Swann JR, Tuohy KM, Lindfors P, Brown DT, Gibson GR, Wilson ID, Sidaway J, Nicholson JK, Holmes E.

J Proteome Res. 2011 Aug 5;10(8):3590-603. doi: 10.1021/pr200243t. Epub 2011 Jun 29.


Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial.

Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage J, Bowman L, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, Parish S, Peto R, Collins R.

Lancet. 2010 Nov 13;376(9753):1658-69. doi: 10.1016/S0140-6736(10)60310-8. Epub 2010 Nov 8. Erratum in: Lancet. 2011 Jan 8;377(9760):126.


Systemic gut microbial modulation of bile acid metabolism in host tissue compartments.

Swann JR, Want EJ, Geier FM, Spagou K, Wilson ID, Sidaway JE, Nicholson JK, Holmes E.

Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4523-30. doi: 10.1073/pnas.1006734107. Epub 2010 Sep 13.


Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.

Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group, Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, Parish S, Sleight P, Peto R, Collins R.

JAMA. 2010 Jun 23;303(24):2486-94. doi: 10.1001/jama.2010.840.


Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

Clarke R, Peden JF, Hopewell JC, Kyriakou T, Goel A, Heath SC, Parish S, Barlera S, Franzosi MG, Rust S, Bennett D, Silveira A, Malarstig A, Green FR, Lathrop M, Gigante B, Leander K, de Faire U, Seedorf U, Hamsten A, Collins R, Watkins H, Farrall M; PROCARDIS Consortium.

N Engl J Med. 2009 Dec 24;361(26):2518-28. doi: 10.1056/NEJMoa0902604.


Statin cost-effectiveness in the United States for people at different vascular risk levels.

Heart Protection Study Collaborative Group.

Circ Cardiovasc Qual Outcomes. 2009 Mar;2(2):65-72. doi: 10.1161/CIRCOUTCOMES.108.808469. Epub 2009 Mar 5.


Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.

Swann J, Wang Y, Abecia L, Costabile A, Tuohy K, Gibson G, Roberts D, Sidaway J, Jones H, Wilson ID, Nicholson J, Holmes E.

Mol Biosyst. 2009 Apr;5(4):351-5. doi: 10.1039/b811468d. Epub 2009 Jan 23.


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