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Items: 1 to 20 of 51

1.

Systemic DNA damage responses in aging and diseases.

Ribezzo F, Shiloh Y, Schumacher B.

Semin Cancer Biol. 2016 Jun;37-38:26-35. doi: 10.1016/j.semcancer.2015.12.005. Epub 2016 Jan 7. Review.

2.

The COP9 signalosome is vital for timely repair of DNA double-strand breaks.

Meir M, Galanty Y, Kashani L, Blank M, Khosravi R, Fernández-Ávila MJ, Cruz-García A, Star A, Shochot L, Thomas Y, Garrett LJ, Chamovitz DA, Bodine DM, Kurz T, Huertas P, Ziv Y, Shiloh Y.

Nucleic Acids Res. 2015 May 19;43(9):4517-30. doi: 10.1093/nar/gkv270. Epub 2015 Apr 8.

3.

The ATM protein: the importance of being active.

Shiloh Y, Ziv Y.

J Cell Biol. 2012 Aug 6;198(3):273-5. doi: 10.1083/jcb.201207063.

4.

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.

Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y.

Cell Cycle. 2011 Dec 15;10(24):4300-10. doi: 10.4161/cc.10.24.18642. Epub 2011 Dec 15.

5.

Matrin 3 binds and stabilizes mRNA.

Salton M, Elkon R, Borodina T, Davydov A, Yaspo ML, Halperin E, Shiloh Y.

PLoS One. 2011;6(8):e23882. doi: 10.1371/journal.pone.0023882. Epub 2011 Aug 17.

6.

A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia.

Raz-Prag D, Galron R, Segev-Amzaleg N, Solomon AS, Shiloh Y, Barzilai A, Frenkel D.

Am J Pathol. 2011 Sep;179(3):1533-41. doi: 10.1016/j.ajpath.2011.05.026. Epub 2011 Jul 19.

7.

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.

Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Ström CE, Helleday T, Hu MC, Chen DJ, Shiloh Y.

EMBO Rep. 2011 Jul 1;12(7):713-9. doi: 10.1038/embor.2011.96.

8.

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.

Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, Ciechanover A, Dahm-Daphi J, Kanaar R, Hu MC, Chen DJ, Oren M, Shiloh Y.

Mol Cell. 2011 Mar 4;41(5):529-42. doi: 10.1016/j.molcel.2011.02.015.

9.

Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.

Dar I, Yosha G, Elfassy R, Galron R, Wang ZQ, Shiloh Y, Barzilai A.

J Biol Chem. 2011 Apr 29;286(17):15361-76. doi: 10.1074/jbc.M110.204172. Epub 2011 Feb 7.

10.

SPIKE: a database of highly curated human signaling pathways.

Paz A, Brownstein Z, Ber Y, Bialik S, David E, Sagir D, Ulitsky I, Elkon R, Kimchi A, Avraham KB, Shiloh Y, Shamir R.

Nucleic Acids Res. 2011 Jan;39(Database issue):D793-9. doi: 10.1093/nar/gkq1167. Epub 2010 Nov 19.

11.

3rd US-EU workshop: systems level understanding of DNA damage responses.

Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L.

Mutat Res. 2010 Oct 13;692(1-2):53-60. doi: 10.1016/j.mrfmmm.2010.07.012. Epub 2010 Aug 19.

12.

Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.

Barash H, R Gross E, Edrei Y, Ella E, Israel A, Cohen I, Corchia N, Ben-Moshe T, Pappo O, Pikarsky E, Goldenberg D, Shiloh Y, Galun E, Abramovitch R.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2207-12. doi: 10.1073/pnas.0908867107. Epub 2010 Jan 25.

13.

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.

Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.

EMBO J. 2009 Dec 2;28(23):3667-80. doi: 10.1038/emboj.2009.302. Epub 2009 Oct 22.

14.

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.

Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, Bustin M.

Nat Cell Biol. 2009 Jan;11(1):92-6. doi: 10.1038/ncb1817. Epub 2008 Dec 14.

15.

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M.

Genes Dev. 2008 Oct 1;22(19):2664-76. doi: 10.1101/gad.1703008.

16.

WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA.

Mol Biol Cell. 2008 Sep;19(9):3923-33. doi: 10.1091/mbc.E07-07-0698. Epub 2008 Jul 2.

17.

SPIKE--a database, visualization and analysis tool of cellular signaling pathways.

Elkon R, Vesterman R, Amit N, Ulitsky I, Zohar I, Weisz M, Mass G, Orlev N, Sternberg G, Blekhman R, Assa J, Shiloh Y, Shamir R.

BMC Bioinformatics. 2008 Feb 20;9:110. doi: 10.1186/1471-2105-9-110.

18.

Functional genomic delineation of TLR-induced transcriptional networks.

Elkon R, Linhart C, Halperin Y, Shiloh Y, Shamir R.

BMC Genomics. 2007 Oct 29;8:394.

19.

Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

Pereg Y, Lam S, Teunisse A, Biton S, Meulmeester E, Mittelman L, Buscemi G, Okamoto K, Taya Y, Shiloh Y, Jochemsen AG.

Mol Cell Biol. 2006 Sep;26(18):6819-31.

20.

Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage.

Blank M, Lerenthal Y, Mittelman L, Shiloh Y.

J Cell Biol. 2006 Jul 17;174(2):195-206.

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