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The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS.

Rhoads SN, Monahan ZT, Yee DS, Shewmaker FP.

Int J Mol Sci. 2018 Mar 16;19(3). pii: E886. doi: 10.3390/ijms19030886. Review.


A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, Nourse A, Ramirez Montero D, Ryan VH, Rohatgi R, Shewmaker F, Naik MT, Mittag T, Ayala YM, Fawzi NL.

EMBO J. 2018 Mar 1;37(5). pii: e97452. doi: 10.15252/embj.201797452. Epub 2018 Feb 9.


Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity.

Monahan Z, Ryan VH, Janke AM, Burke KA, Rhoads SN, Zerze GH, O'Meally R, Dignon GL, Conicella AE, Zheng W, Best RB, Cole RN, Mittal J, Shewmaker F, Fawzi NL.

EMBO J. 2017 Oct 16;36(20):2951-2967. doi: 10.15252/embj.201696394. Epub 2017 Aug 8.


Stress granules at the intersection of autophagy and ALS.

Monahan Z, Shewmaker F, Pandey UB.

Brain Res. 2016 Oct 15;1649(Pt B):189-200. doi: 10.1016/j.brainres.2016.05.022. Epub 2016 May 13. Review.


Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.

Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB.

Acta Neuropathol. 2016 Apr;131(4):605-20. doi: 10.1007/s00401-015-1530-0. Epub 2016 Jan 4.


Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan.

Villapol S, Kryndushkin D, Balarezo MG, Campbell AM, Saavedra JM, Shewmaker FP, Symes AJ.

Am J Pathol. 2015 Oct;185(10):2641-52. doi: 10.1016/j.ajpath.2015.06.016.


Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates.

Wear MP, Kryndushkin D, O'Meally R, Sonnenberg JL, Cole RN, Shewmaker FP.

PLoS One. 2015 Aug 28;10(8):e0136362. doi: 10.1371/journal.pone.0136362. eCollection 2015.


Yeast prions: structure, biology, and prion-handling systems.

Wickner RB, Shewmaker FP, Bateman DA, Edskes HK, Gorkovskiy A, Dayani Y, Bezsonov EE.

Microbiol Mol Biol Rev. 2015 Mar;79(1):1-17. doi: 10.1128/MMBR.00041-14. Review.


Amyloid cannot resist identification.

Kryndushkin D, Wear MP, Shewmaker F.

Prion. 2013 Nov-Dec;7(6):464-8. Epub 2013 Dec 23. Review.


Non-targeted identification of prions and amyloid-forming proteins from yeast and mammalian cells.

Kryndushkin D, Pripuzova N, Burnett BG, Shewmaker F.

J Biol Chem. 2013 Sep 20;288(38):27100-11. doi: 10.1074/jbc.M113.485359. Epub 2013 Aug 7.


RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations.

Daigle JG, Lanson NA Jr, Smith RB, Casci I, Maltare A, Monaghan J, Nichols CD, Kryndushkin D, Shewmaker F, Pandey UB.

Hum Mol Genet. 2013 Mar 15;22(6):1193-205. doi: 10.1093/hmg/dds526. Epub 2012 Dec 20.


Sex, prions, and plasmids in yeast.

Kelly AC, Shewmaker FP, Kryndushkin D, Wickner RB.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):E2683-90. doi: 10.1073/pnas.1213449109. Epub 2012 Sep 4.


Study of amyloids using yeast.

Wickner RB, Kryndushkin D, Shewmaker F, McGlinchey R, Edskes HK.

Methods Mol Biol. 2012;849:321-46. doi: 10.1007/978-1-61779-551-0_22.


Modeling ALS and FTLD proteinopathies in yeast: an efficient approach for studying protein aggregation and toxicity.

Kryndushkin D, Shewmaker F.

Prion. 2011 Oct-Dec;5(4):250-7. doi: 10.4161/pri.17229. Epub 2011 Oct 1. Review.


Amyloid of the Candida albicans Ure2p prion domain is infectious and has an in-register parallel β-sheet structure.

Engel A, Shewmaker F, Edskes HK, Dyda F, Wickner RB.

Biochemistry. 2011 Jul 12;50(27):5971-8. doi: 10.1021/bi200142x. Epub 2011 Jun 15.


Structural insights into functional and pathological amyloid.

Shewmaker F, McGlinchey RP, Wickner RB.

J Biol Chem. 2011 May 13;286(19):16533-40. doi: 10.1074/jbc.R111.227108. Epub 2011 Mar 25. Review.


FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis.

Kryndushkin D, Wickner RB, Shewmaker F.

Protein Cell. 2011 Mar;2(3):223-36. doi: 10.1007/s13238-011-1525-0. Epub 2011 Mar 30.


The relationship of prions and translation.

Wickner RB, Edskes HK, Shewmaker FP, Kryndushkin D, Nemecek J, McGlinchey R, Bateman D.

Wiley Interdiscip Rev RNA. 2010 Jul-Aug;1(1):81-9. doi: 10.1002/wrna.8. Review.


Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH.

McGlinchey RP, Shewmaker F, Hu KN, McPhie P, Tycko R, Wickner RB.

J Biol Chem. 2011 Mar 11;286(10):8385-93. doi: 10.1074/jbc.M110.197152. Epub 2010 Dec 10.


Prion amyloid structure explains templating: how proteins can be genes.

Wickner RB, Shewmaker F, Edskes H, Kryndushkin D, Nemecek J, McGlinchey R, Bateman D, Winchester CL.

FEMS Yeast Res. 2010 Dec;10(8):980-91. doi: 10.1111/j.1567-1364.2010.00666.x. Review.

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