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Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.

Infante JR, Korn RL, Rosen LS, LoRusso P, Dychter SS, Zhu J, Maneval DC, Jiang P, Shepard HM, Frost G, Von Hoff DD, Borad MJ, Ramanathan RK.

Br J Cancer. 2018 Jan;118(2):e3. doi: 10.1038/bjc.2017.438.


Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.

Infante JR, Korn RL, Rosen LS, LoRusso P, Dychter SS, Zhu J, Maneval DC, Jiang P, Shepard HM, Frost G, Von Hoff DD, Borad MJ, Ramanathan RK.

Br J Cancer. 2018 Jan;118(2):153-161. doi: 10.1038/bjc.2017.327. Epub 2017 Sep 26. Erratum in: Br J Cancer. 2018 Jan;118(2):e3.


Developments in therapy with monoclonal antibodies and related proteins.

Shepard HM, Phillips GL, D Thanos C, Feldmann M.

Clin Med (Lond). 2017 Jun;17(3):220-232. doi: 10.7861/clinmedicine.17-3-220. Review.


PH20 is not expressed in murine CNS and oligodendrocyte precursor cells.

Marella M, Ouyang J, Zombeck J, Zhao C, Huang L, Connor RJ, Phan KB, Jorge MC, Printz MA, Paladini RD, Gelb AB, Huang Z, Frost GI, Sugarman BJ, Steinman L, Wei G, Shepard HM, Maneval DC, Lapinskas PJ.

Ann Clin Transl Neurol. 2017 Feb 23;4(3):191-211. doi: 10.1002/acn3.393. eCollection 2017 Mar.


Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer.

Hingorani SR, Harris WP, Beck JT, Berdov BA, Wagner SA, Pshevlotsky EM, Tjulandin SA, Gladkov OA, Holcombe RF, Korn R, Raghunand N, Dychter S, Jiang P, Shepard HM, Devoe CE.

Clin Cancer Res. 2016 Jun 15;22(12):2848-54. doi: 10.1158/1078-0432.CCR-15-2010. Epub 2016 Jan 26.


Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy.

Shepard HM.

Front Oncol. 2015 Aug 28;5:192. doi: 10.3389/fonc.2015.00192. eCollection 2015. Review.


Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer.

Whatcott CJ, Diep CH, Jiang P, Watanabe A, LoBello J, Sima C, Hostetter G, Shepard HM, Von Hoff DD, Han H.

Clin Cancer Res. 2015 Aug 1;21(15):3561-8. doi: 10.1158/1078-0432.CCR-14-1051. Epub 2015 Feb 18.


Tumor-associated hyaluronan limits efficacy of monoclonal antibody therapy.

Singha NC, Nekoroski T, Zhao C, Symons R, Jiang P, Frost GI, Huang Z, Shepard HM.

Mol Cancer Ther. 2015 Feb;14(2):523-32. doi: 10.1158/1535-7163.MCT-14-0580. Epub 2014 Dec 15.


Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.

Kultti A, Zhao C, Singha NC, Zimmerman S, Osgood RJ, Symons R, Jiang P, Li X, Thompson CB, Infante JR, Jacobetz MA, Tuveson DA, Frost GI, Shepard HM, Huang Z.

Biomed Res Int. 2014;2014:817613. doi: 10.1155/2014/817613. Epub 2014 Jul 24.


Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning.

DelGiorno KE, Carlson MA, Osgood R, Provenzano PP, Brockenbough JS, Thompson CB, Shepard HM, Frost GI, Potter JD, Hingorani SR.

Cancer Cell. 2014 Jul 14;26(1):16-7. doi: 10.1016/j.ccr.2014.06.004. No abstract available.


Characterization of a novel recombinant hyaluronan binding protein for tissue hyaluronan detection.

Jadin L, Huang L, Wei G, Zhao Q, Gelb AB, Frost GI, Jiang P, Shepard HM.

J Histochem Cytochem. 2014 Sep;62(9):672-83. doi: 10.1369/0022155414540176. Epub 2014 Jun 2.


Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation.

Huang Z, Zhao C, Chen Y, Cowell JA, Wei G, Kultti A, Huang L, Thompson CB, Rosengren S, Frost GI, Shepard HM.

J Immunol. 2014 Jun 1;192(11):5285-95. doi: 10.4049/jimmunol.1303060. Epub 2014 Apr 28.


Mutations in the catalytic domain of human matrix metalloproteinase-1 (MMP-1) that allow for regulated activity through the use of Ca2+.

Paladini RD, Wei G, Kundu A, Zhao Q, Bookbinder LH, Keller GA, Shepard HM, Frost GI.

J Biol Chem. 2013 Mar 1;288(9):6629-39. doi: 10.1074/jbc.M112.364729. Epub 2013 Jan 15.


Effective targeting of the tumor microenvironment for cancer therapy.

Jiang P, Li X, Thompson CB, Huang Z, Araiza F, Osgood R, Wei G, Feldmann M, Frost GI, Shepard HM.

Anticancer Res. 2012 Apr;32(4):1203-12.


Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.

Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, Lolkema MP, Jiang P, Kultti A, Thompson CB, Maneval DC, Jodrell DI, Frost GI, Shepard HM, Skepper JN, Tuveson DA.

Gut. 2013 Jan;62(1):112-20. doi: 10.1136/gutjnl-2012-302529. Epub 2012 Mar 30.


Therapeutic targeting of hyaluronan in the tumor stroma.

Kultti A, Li X, Jiang P, Thompson CB, Frost GI, Shepard HM.

Cancers (Basel). 2012 Sep 6;4(3):873-903. doi: 10.3390/cancers4030873.


Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade.

Gompels LL, Malik NM, Madden L, Jin P, Feldmann M, Shepard HM, Paleolog EM.

Arthritis Res Ther. 2011;13(5):R161. doi: 10.1186/ar3480. Epub 2011 Oct 7.


Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models.

Thompson CB, Shepard HM, O'Connor PM, Kadhim S, Jiang P, Osgood RJ, Bookbinder LH, Li X, Sugarman BJ, Connor RJ, Nadjsombati S, Frost GI.

Mol Cancer Ther. 2010 Nov;9(11):3052-64. doi: 10.1158/1535-7163.MCT-10-0470. Epub 2010 Oct 26.


A pan-HER approach for cancer therapy: background, current status and future development.

Huang Z, Brdlik C, Jin P, Shepard HM.

Expert Opin Biol Ther. 2009 Jan;9(1):97-110. doi: 10.1517/14712590802630427 . Review.


Rational optimization of a bispecific ligand trap targeting EGF receptor family ligands.

Jin P, Zhang J, Beryt M, Turin L, Brdlik C, Feng Y, Bai X, Liu J, Jorgensen B, Shepard HM.

Mol Med. 2009 Jan-Feb;15(1-2):11-20. doi: 10.2119/molmed.2008.00103. Epub 2008 Nov 17.

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