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A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue.

Talos F, Mitrofanova A, Bergren SK, Califano A, Shen MM.

Nat Commun. 2017 Apr 21;8:14662. doi: 10.1038/ncomms14662.


Comparative lineage tracing reveals cellular preferences for prostate cancer initiation.

Wang ZA, Shen MM.

Mol Cell Oncol. 2015 Feb 25;2(3):e985548. doi: 10.4161/23723556.2014.985548. eCollection 2015 Jul-Sep.


Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis.

Toivanen R, Mohan A, Shen MM.

Stem Cell Reports. 2016 May 10;6(5):660-667. doi: 10.1016/j.stemcr.2016.03.007. Epub 2016 Apr 21.


Atg7 cooperates with Pten loss to drive prostate cancer tumor growth.

Santanam U, Banach-Petrosky W, Abate-Shen C, Shen MM, White E, DiPaola RS.

Genes Dev. 2016 Feb 15;30(4):399-407. doi: 10.1101/gad.274134.115.


Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway.

Klauzinska M, McCurdy D, Rangel MC, Vaidyanath A, Castro NP, Shen MM, Gonzales M, Bertolette D, Bianco C, Callahan R, Salomon DS, Raafat A.

Am J Pathol. 2015 Nov;185(11):2907-22. doi: 10.1016/j.ajpath.2015.07.023. Epub 2015 Oct 1.


ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm.

Ellis PS, Burbridge S, Soubes S, Ohyama K, Ben-Haim N, Chen C, Dale K, Shen MM, Constam D, Placzek M.

Development. 2015 Nov 15;142(22):3821-32. doi: 10.1242/dev.119628. Epub 2015 Sep 28.


Predicting Drug Response in Human Prostate Cancer from Preclinical Analysis of In Vivo Mouse Models.

Mitrofanova A, Aytes A, Zou M, Shen MM, Abate-Shen C, Califano A.

Cell Rep. 2015 Sep 29;12(12):2060-71. doi: 10.1016/j.celrep.2015.08.051. Epub 2015 Sep 17.


Stem cells in genetically-engineered mouse models of prostate cancer.

Shibata M, Shen MM.

Endocr Relat Cancer. 2015 Dec;22(6):T199-208. doi: 10.1530/ERC-15-0367. Epub 2015 Sep 4. Review.


Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.

Hogan MS, Parfitt DE, Zepeda-Mendoza CJ, Shen MM, Spector DL.

Cell Stem Cell. 2015 Mar 5;16(3):275-88. doi: 10.1016/j.stem.2015.02.001.


From blastocyst to gastrula: gene regulatory networks of embryonic stem cells and early mouse embryogenesis.

Parfitt DE, Shen MM.

Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). pii: 20130542. doi: 10.1098/rstb.2013.0542. Review.


Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks.

Chen JC, Alvarez MJ, Talos F, Dhruv H, Rieckhof GE, Iyer A, Diefes KL, Aldape K, Berens M, Shen MM, Califano A.

Cell. 2014 Oct 9;159(2):402-14. doi: 10.1016/j.cell.2014.09.021. Erratum in: Cell. 2016 Aug 11;166(4):1055.


Single luminal epithelial progenitors can generate prostate organoids in culture.

Chua CW, Shibata M, Lei M, Toivanen R, Barlow LJ, Bergren SK, Badani KK, McKiernan JM, Benson MC, Hibshoosh H, Shen MM.

Nat Cell Biol. 2014 Oct;16(10):951-61, 1-4. doi: 10.1038/ncb3047. Epub 2014 Sep 21.


Luminal cells are favored as the cell of origin for prostate cancer.

Wang ZA, Toivanen R, Bergren SK, Chambon P, Shen MM.

Cell Rep. 2014 Sep 11;8(5):1339-46. doi: 10.1016/j.celrep.2014.08.002. Epub 2014 Aug 28.


Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.

Aytes A, Mitrofanova A, Lefebvre C, Alvarez MJ, Castillo-Martin M, Zheng T, Eastham JA, Gopalan A, Pienta KJ, Shen MM, Califano A, Abate-Shen C.

Cancer Cell. 2014 May 12;25(5):638-651. doi: 10.1016/j.ccr.2014.03.017.


A molecular signature predictive of indolent prostate cancer.

Irshad S, Bansal M, Castillo-Martin M, Zheng T, Aytes A, Wenske S, Le Magnen C, Guarnieri P, Sumazin P, Benson MC, Shen MM, Califano A, Abate-Shen C.

Sci Transl Med. 2013 Sep 11;5(202):202ra122. doi: 10.1126/scitranslmed.3006408. Erratum in: Sci Transl Med. 2013 Sep 18;5(203):203er9.


ETV4 promotes metastasis in response to activation of PI3-kinase and Ras signaling in a mouse model of advanced prostate cancer.

Aytes A, Mitrofanova A, Kinkade CW, Lefebvre C, Lei M, Phelan V, LeKaye HC, Koutcher JA, Cardiff RD, Califano A, Shen MM, Abate-Shen C.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):E3506-15. doi: 10.1073/pnas.1303558110. Epub 2013 Aug 5.


Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis.

Kruithof-de Julio M, Shibata M, Desai N, Reynon M, Halili MV, Hu YP, Price SM, Abate-Shen C, Shen MM.

Dev Dyn. 2013 Oct;242(10):1160-71. doi: 10.1002/dvdy.24008. Epub 2013 Jul 29.


Chromoplexy: a new category of complex rearrangements in the cancer genome.

Shen MM.

Cancer Cell. 2013 May 13;23(5):567-9. doi: 10.1016/j.ccr.2013.04.025.


Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity.

Wang ZA, Mitrofanova A, Bergren SK, Abate-Shen C, Cardiff RD, Califano A, Shen MM.

Nat Cell Biol. 2013 Mar;15(3):274-83. doi: 10.1038/ncb2697. Epub 2013 Feb 24.


Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin.

Guardiola O, Lafuste P, Brunelli S, Iaconis S, Touvier T, Mourikis P, De Bock K, Lonardo E, Andolfi G, Bouché A, Liguori GL, Shen MM, Tajbakhsh S, Cossu G, Carmeliet P, Minchiotti G.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3231-40. doi: 10.1073/pnas.1204017109. Epub 2012 Nov 5.

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