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Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.

Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5048-57. doi: 10.1073/pnas.1507245112.


Sbi00515, a Protein of Unknown Function from Streptomyces bingchenggensis, Highlights the Functional Versatility of the Acetoacetate Decarboxylase Scaffold.

Mueller LS, Hoppe RW, Ochsenwald JM, Berndt RT, Severin GB, Schwabacher AW, Silvaggi NR.

Biochemistry. 2015 Jun 30;54(25):3978-88. doi: 10.1021/acs.biochem.5b00483.


The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP.

Hunter JL, Severin GB, Koestler BJ, Waters CM.

BMC Microbiol. 2014 Feb 4;14:22. doi: 10.1186/1471-2180-14-22.

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