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Items: 1 to 20 of 269


Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease.

Pandey MK, Burrow TA, Rani R, Martin LJ, Witte D, Setchell KD, Mckay MA, Magnusen AF, Zhang W, Liou B, Köhl J, Grabowski GA.

Nature. 2017 Mar 2;543(7643):108-112. doi: 10.1038/nature21368.


Fibroblast growth factor 21 correlates with weight loss after vertical sleeve gastrectomy in adolescents.

Khan FH, Shaw L, Zhang W, Salazar Gonzalez RM, Mowery S, Oehrle M, Zhao X, Jenkins T, Setchell KD, Inge TH, Kohli R.

Obesity (Silver Spring). 2016 Nov;24(11):2377-2383. doi: 10.1002/oby.21658.


Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

Jian J, Tian QY, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell KD, Sun Y, Overkleeft HS, Chan GL, Liu CJ.

EBioMedicine. 2016 Nov;13:212-224. doi: 10.1016/j.ebiom.2016.10.010.


Stable-Isotope Dilution HPLC-Electrospray Ionization Tandem Mass Spectrometry Method for Quantifying Hydroxyurea in Dried Blood Samples.

Marahatta A, Megaraj V, McGann PT, Ware RE, Setchell KD.

Clin Chem. 2016 Dec;62(12):1593-1601.


Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice.

Rao A, Kosters A, Mells JE, Zhang W, Setchell KD, Amanso AM, Wynn GM, Xu T, Keller BT, Yin H, Banton S, Jones DP, Wu H, Dawson PA, Karpen SJ.

Sci Transl Med. 2016 Sep 21;8(357):357ra122. doi: 10.1126/scitranslmed.aaf4823.


Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice.

Liou B, Peng Y, Li R, Inskeep V, Zhang W, Quinn B, Dasgupta N, Blackwood R, Setchell KD, Fleming S, Grabowski GA, Marshall J, Sun Y.

Hum Mol Genet. 2016 Sep 20. pii: ddw322. doi: 10.1093/hmg/ddw322. [Epub ahead of print]


Combination Therapy of All-Trans Retinoic Acid With Ursodeoxycholic Acid in Patients With Primary Sclerosing Cholangitis: A Human Pilot Study.

Assis DN, Abdelghany O, Cai SY, Gossard AA, Eaton JE, Keach JC, Deng Y, Setchell KD, Ciarleglio M, Lindor KD, Boyer JL.

J Clin Gastroenterol. 2017 Feb;51(2):e11-e16. doi: 10.1097/MCG.0000000000000591.


Long-Term Ursodeoxycholic Acid Therapy Does Not Alter Lithocholic Acid Levels in Patients with Cystic Fibrosis with Associated Liver Disease.

Colombo C, Crosignani A, Alicandro G, Zhang W, Biffi A, Motta V, Corti F, Setchell KD.

J Pediatr. 2016 Oct;177:59-65.e1. doi: 10.1016/j.jpeds.2016.05.008.


Neuronopathic Gaucher disease: dysregulated mRNAs and miRNAs in brain pathogenesis and effects of pharmacologic chaperone treatment in a mouse model.

Dasgupta N, Xu YH, Li R, Peng Y, Pandey MK, Tinch SL, Liou B, Inskeep V, Zhang W, Setchell KD, Keddache M, Grabowski GA, Sun Y.

Hum Mol Genet. 2015 Dec 15;24(24):7031-48. doi: 10.1093/hmg/ddv404.


Cognitive Effects of Soy Isoflavones in Patients with Alzheimer's Disease.

Gleason CE, Fischer BL, Dowling NM, Setchell KD, Atwood CS, Carlsson CM, Asthana S.

J Alzheimers Dis. 2015;47(4):1009-19. doi: 10.3233/JAD-142958.


Let the bile flow!

Kohli R, Setchell KD.

Hepatology. 2015 Dec;62(6):1870. doi: 10.1002/hep.28244. No abstract available.


Differential Requirements for L-Citrulline and L-Arginine during Antimycobacterial Macrophage Activity.

Rapovy SM, Zhao J, Bricker RL, Schmidt SM, Setchell KD, Qualls JE.

J Immunol. 2015 Oct 1;195(7):3293-300. doi: 10.4049/jimmunol.1500800.


Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice.

Miethke AG, Zhang W, Simmons J, Taylor AE, Shi T, Shanmukhappa SK, Karns R, White S, Jegga AG, Lages CS, Nkinin S, Keller BT, Setchell KD.

Hepatology. 2016 Feb;63(2):512-23. doi: 10.1002/hep.27973.


Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?

Kohli R, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD.

Dig Dis. 2015;33(3):440-6. doi: 10.1159/000371699. Review.


Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology.

Sun Y, Florer J, Mayhew CN, Jia Z, Zhao Z, Xu K, Ran H, Liou B, Zhang W, Setchell KD, Gu J, Grabowski GA.

PLoS One. 2015 Mar 30;10(3):e0118771. doi: 10.1371/journal.pone.0118771.


S-equol: a potential nonhormonal agent for menopause-related symptom relief.

Utian WH, Jones M, Setchell KD.

J Womens Health (Larchmt). 2015 Mar;24(3):200-8. doi: 10.1089/jwh.2014.5006.


Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.

Pooya S, Liu X, Kumar VB, Anderson J, Imai F, Zhang W, Ciraolo G, Ratner N, Setchell KD, Yoshida Y, Jankowski MP, Dasgupta B.

Nat Commun. 2015 Jan 9;6:6075. doi: 10.1038/ncomms7075. No abstract available.


Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.

Barnes S, Xu YH, Zhang W, Liou B, Setchell KD, Bao L, Grabowski GA, Sun Y.

PLoS One. 2014 Dec 31;9(12):e116023. doi: 10.1371/journal.pone.0116023.


The role of small heterodimer partner in nonalcoholic fatty liver disease improvement after sleeve gastrectomy in mice.

Myronovych A, Salazar-Gonzalez RM, Ryan KK, Miles L, Zhang W, Jha P, Wang L, Setchell KD, Seeley RJ, Kohli R.

Obesity (Silver Spring). 2014 Nov;22(11):2301-11. doi: 10.1002/oby.20890.

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