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Growth Horm IGF Res. 2007 Dec;17(6):506-11. Epub 2007 Jun 29.

Serum levels of insulin-like growth factor-I in relation to organochlorine pesticides exposure.

Author information

1
Toxicology Unit, Department of Clinical Sciences, Health Sciences Faculty, University of Las Palmas de Gran Canaria, Las Palmas, Spain. ldominguez@dcc.ulpgc.es

Abstract

CONTEXT:

Insulin-like growth factor 1 (IGF-I) and organochlorine pesticides (OCs) have been involved in the pathogenesis of several diseases like cancer, diabetes and growth disorders.

OBJECTIVE AND DESIGN:

The potential relationship between the serum levels of various OCs and serum IGF-I was investigated in adults (176 men and 247 women) from a representative sample of the general population of the Canary Islands (Spain).

RESULTS:

After adjustment for potential confounders, which include body mass index, age, and IGF-binding protein-3 (IGFBP-3), IGF-I levels were significantly lower in the 247 women who showed detectable levels of p,p'-DDD (a DDT-metabolite) than in women who presented non-detectable levels of this pesticide (p=0.030), specially in 36-50 years old women. A similar negative relationship was also found between IGF-I and aldrin (a non-DDT-derivative) in women (p=0.049). In the group of 176 men, aldrin seemed to exert a similar negative effect on IGF-I (p=0.046) and this effect was clearly significant in the oldest group (51-65 years) (p=0.009). A non-linear dose-response curve was observed between Total Cyclodienes Body Burden (Total Cyclodienes; sum of aldrin, dieldrin and endrin) and IGF-I in men (p=0.024). These findings suggest that OCs could modulate the IGF-system in a way that is highly influenced by gender, age and by chemical or combination of chemicals implicated. Such circumstances may contribute to the development of a number of diseases related to IGF-I and should be taken into account in public health decisions.

PMID:
17601760
DOI:
10.1016/j.ghir.2007.05.004
[Indexed for MEDLINE]

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