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Items: 1 to 20 of 405


Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM.

Int J Mol Sci. 2018 Feb 27;19(3). pii: E663. doi: 10.3390/ijms19030663.


Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL.

Stem Cell Reports. 2017 Dec 12;9(6):1868-1884. doi: 10.1016/j.stemcr.2017.10.015. Epub 2017 Nov 16.


β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.


Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory.

Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY.

Cell Rep. 2017 Aug 8;20(6):1335-1347. doi: 10.1016/j.celrep.2017.07.030.


A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.

Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P; Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson's Research.

Mov Disord. 2017 Aug;32(8):1117-1130. doi: 10.1002/mds.27090. Epub 2017 Jul 22. Review.


Showing transmitters the door: synucleins accelerate vesicle release.

Selkoe DJ.

Nat Neurosci. 2017 Apr 25;20(5):629-631. doi: 10.1038/nn.4551. No abstract available.


Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.

Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL.

Dev Biol. 2017 Apr 15;424(2):138-146. doi: 10.1016/j.ydbio.2017.03.007. Epub 2017 Mar 8.


Enzymatic Assays for Studying Intramembrane Proteolysis.

Bolduc DM, Selkoe DJ, Wolfe MS.

Methods Enzymol. 2017;584:295-308. doi: 10.1016/bs.mie.2016.10.026. Epub 2016 Dec 24.


Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

Yang T, Li S, Xu H, Walsh DM, Selkoe DJ.

J Neurosci. 2017 Jan 4;37(1):152-163. doi: 10.1523/JNEUROSCI.1698-16.2016.


The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ.

Elife. 2016 Aug 31;5. pii: e17578. doi: 10.7554/eLife.17578.


Caspase-1 clipping causes complications for α-synuclein.

Nuber S, Selkoe DJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9958-60. doi: 10.1073/pnas.1610993113. Epub 2016 Aug 22. No abstract available.


Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.

Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2138-41. doi: 10.1016/j.bmcl.2016.03.077. Epub 2016 Mar 23.


Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B.

Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31.


The amyloid hypothesis of Alzheimer's disease at 25 years.

Selkoe DJ, Hardy J.

EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. Print 2016 Jun. Review.


Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols.

Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2133-7. doi: 10.1016/j.bmcl.2016.03.042. Epub 2016 Mar 15.


Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.

Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2129-32. doi: 10.1016/j.bmcl.2016.03.040. Epub 2016 Mar 12.


A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Walsh DM, Selkoe DJ.

Nat Rev Neurosci. 2016 Apr;17(4):251-60. doi: 10.1038/nrn.2016.13. Review.


Editorial overview: Neurobiology of disease.

Selkoe DJ, Weinberger DR.

Curr Opin Neurobiol. 2016 Feb;36:v-vii. doi: 10.1016/j.conb.2016.01.001. Epub 2016 Jan 18. No abstract available.


Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E509-18. doi: 10.1073/pnas.1512952113. Epub 2015 Dec 22.


Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.

Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ.

J Cell Biol. 2015 Dec 21;211(6):1157-76. doi: 10.1083/jcb.201502001.

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