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Items: 1 to 20 of 28


The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila.

Drelon C, Belalcazar HM, Secombe J.

Genetics. 2018 Jul;209(3):773-787. doi: 10.1534/genetics.118.301004. Epub 2018 May 15.


A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5.

Zamurrad S, Hatch HAM, Drelon C, Belalcazar HM, Secombe J.

Cell Rep. 2018 Feb 27;22(9):2359-2369. doi: 10.1016/j.celrep.2018.02.018.


Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling.

Navarro-Costa P, McCarthy A, PrudĂȘncio P, Greer C, Guilgur LG, Becker JD, Secombe J, Rangan P, Martinho RG.

Nat Commun. 2016 Aug 10;7:12331. doi: 10.1038/ncomms12331.


The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif.

Liu X, Secombe J.

Cell Rep. 2015 Dec 15;13(10):2219-31. doi: 10.1016/j.celrep.2015.11.007. Epub 2015 Dec 7.


KDM5 interacts with Foxo to modulate cellular levels of oxidative stress.

Liu X, Greer C, Secombe J.

PLoS Genet. 2014 Oct 16;10(10):e1004676. doi: 10.1371/journal.pgen.1004676. eCollection 2014 Oct.


The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth.

Li L, Anderson S, Secombe J, Eisenman RN.

Development. 2013 Dec;140(23):4776-87. doi: 10.1242/dev.096941. Epub 2013 Oct 30.


Myc-dependent genome instability and lifespan in Drosophila.

Greer C, Lee M, Westerhof M, Milholland B, Spokony R, Vijg J, Secombe J.

PLoS One. 2013 Sep 6;8(9):e74641. doi: 10.1371/journal.pone.0074641. eCollection 2013.


Myc in stem cell behaviour: insights from Drosophila.

Quinn LM, Secombe J, Hime GR.

Adv Exp Med Biol. 2013;786:269-85. doi: 10.1007/978-94-007-6621-1_15. Review.


Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.

DiTacchio L, Le HD, Vollmers C, Hatori M, Witcher M, Secombe J, Panda S.

Science. 2011 Sep 30;333(6051):1881-5. doi: 10.1126/science.1206022.


Essential functions of the histone demethylase lid.

Li L, Greer C, Eisenman RN, Secombe J.

PLoS Genet. 2010 Nov 24;6(11):e1001221. doi: 10.1371/journal.pgen.1001221.


Addressing cultural safety in the classroom.

Secombe J, Roeters H.

Nurs N Z. 2010 Aug;16(7):22. No abstract available.


Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.

Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE.

Dev Biol. 2007 Nov 1;311(1):106-23. Epub 2007 Aug 17.


The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection.

Secombe J, Eisenman RN.

Cell Cycle. 2007 Jun 1;6(11):1324-8. Epub 2007 Jun 14. Review.


The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.

Secombe J, Li L, Carlos L, Eisenman RN.

Genes Dev. 2007 Mar 1;21(5):537-51. Epub 2007 Feb 20.


The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.

Loo LW, Secombe J, Little JT, Carlos LS, Yost C, Cheng PF, Flynn EM, Edgar BA, Eisenman RN.

Mol Cell Biol. 2005 Aug;25(16):7078-91.


A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.

Brumby A, Secombe J, Horsfield J, Coombe M, Amin N, Coates D, Saint R, Richardson H.

Genetics. 2004 Sep;168(1):227-51.


Myc: a weapon of mass destruction.

Secombe J, Pierce SB, Eisenman RN.

Cell. 2004 Apr 16;117(2):153-6. Review.


Drosophila cyclin E interacts with components of the Brahma complex.

Brumby AM, Zraly CB, Horsfield JA, Secombe J, Saint R, Dingwall AK, Richardson H.

EMBO J. 2002 Jul 1;21(13):3377-89.

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