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Items: 8

1.

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H.

Science. 2017 Sep 14. pii: eaao3130. doi: 10.1126/science.aao3130. [Epub ahead of print]

PMID:
28912133
2.

Tissue-specific mutation accumulation in human adult stem cells during life.

Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R.

Nature. 2016 Oct 13;538(7624):260-264. doi: 10.1038/nature19768. Epub 2016 Oct 3.

3.

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2015 Feb 5;16(2):158-70. doi: 10.1016/j.stem.2014.12.006. Epub 2015 Jan 22.

4.

Retroviral gene expression control in primary organoid cultures.

Koo BK, Sasselli V, Clevers H.

Curr Protoc Stem Cell Biol. 2013 Nov 13;27:Unit 5A.6.. doi: 10.1002/9780470151808.sc05a06s27.

PMID:
24510288
5.

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.

Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H.

Cell Stem Cell. 2013 Dec 5;13(6):653-8. doi: 10.1016/j.stem.2013.11.002.

6.

Planar cell polarity genes control the connectivity of enteric neurons.

Sasselli V, Boesmans W, Vanden Berghe P, Tissir F, Goffinet AM, Pachnis V.

J Clin Invest. 2013 Apr;123(4):1763-72. doi: 10.1172/JCI66759. Epub 2013 Mar 8.

7.

Evaluation of ES-derived neural progenitors as a potential source for cell replacement therapy in the gut.

Sasselli V, Micci MA, Kahrig KM, Pasricha PJ.

BMC Gastroenterol. 2012 Jun 26;12:81. doi: 10.1186/1471-230X-12-81.

8.

The enteric nervous system.

Sasselli V, Pachnis V, Burns AJ.

Dev Biol. 2012 Jun 1;366(1):64-73. doi: 10.1016/j.ydbio.2012.01.012. Epub 2012 Jan 24.

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