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Items: 1 to 20 of 80

1.

A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.

Nair DR, Chen J, Monteiro JM, Josten M, Pinho MG, Sahl HG, Wu J, Cheung A.

J Antibiot (Tokyo). 2017 Oct;70(10):1009-1019. doi: 10.1038/ja.2017.79. Epub 2017 Jul 12.

2.

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Maffioli SI, Zhang Y, Degen D, Carzaniga T, Del Gatto G, Serina S, Monciardini P, Mazzetti C, Guglierame P, Candiani G, Chiriac AI, Facchetti G, Kaltofen P, Sahl HG, Dehò G, Donadio S, Ebright RH.

Cell. 2017 Jun 15;169(7):1240-1248.e23. doi: 10.1016/j.cell.2017.05.042.

3.

Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.

Müller A, Wenzel M, Strahl H, Grein F, Saaki TN, Kohl B, Siersma T, Bandow JE, Sahl HG, Schneider T, Hamoen LW.

Proc Natl Acad Sci U S A. 2016 Oct 24. pii: 201611173. [Epub ahead of print]

4.

Investigations to the Antibacterial Mechanism of Action of Kendomycin.

Elnakady YA, Chatterjee I, Bischoff M, Rohde M, Josten M, Sahl HG, Herrmann M, Müller R.

PLoS One. 2016 Jan 21;11(1):e0146165. doi: 10.1371/journal.pone.0146165. eCollection 2016.

5.

Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway.

Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F.

J Biol Chem. 2016 Jan 29;291(5):2535-46. doi: 10.1074/jbc.M115.664292. Epub 2015 Nov 30.

6.

Co-solvents as stabilizing agents during heterologous overexpression in Escherichia coli - application to chlamydial penicillin-binding protein 6.

Otten C, De Benedetti S, Gaballah A, Bühl H, Klöckner A, Brauner J, Sahl HG, Henrichfreise B.

PLoS One. 2015 Apr 7;10(4):e0122110. doi: 10.1371/journal.pone.0122110. eCollection 2015.

7.

Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides.

Basi-Chipalu S, Dischinger J, Josten M, Szekat C, Zweynert A, Sahl HG, Bierbaum G.

Appl Environ Microbiol. 2015 May 15;81(10):3419-29. doi: 10.1128/AEM.00299-15. Epub 2015 Mar 13.

8.

The lantibiotic nisin induces lipid II aggregation, causing membrane instability and vesicle budding.

Scherer KM, Spille JH, Sahl HG, Grein F, Kubitscheck U.

Biophys J. 2015 Mar 10;108(5):1114-24. doi: 10.1016/j.bpj.2015.01.020.

9.

Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes.

Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG.

Antibiotics (Basel). 2014;3(4):617-31. doi: 10.3390/antibiotics3040617.

10.

Structural variations of the cell wall precursor lipid II and their influence on binding and activity of the lipoglycopeptide antibiotic oritavancin.

Münch D, Engels I, Müller A, Reder-Christ K, Falkenstein-Paul H, Bierbaum G, Grein F, Bendas G, Sahl HG, Schneider T.

Antimicrob Agents Chemother. 2015 Feb;59(2):772-81. doi: 10.1128/AAC.02663-14. Epub 2014 Nov 17.

11.

Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis.

Essig A, Hofmann D, Münch D, Gayathri S, Künzler M, Kallio PT, Sahl HG, Wider G, Schneider T, Aebi M.

J Biol Chem. 2014 Dec 12;289(50):34953-64. doi: 10.1074/jbc.M114.599878. Epub 2014 Oct 23.

12.

Thiosulfate transfer mediated by DsrE/TusA homologs from acidothermophilic sulfur-oxidizing archaeon Metallosphaera cuprina.

Liu LJ, Stockdreher Y, Koch T, Sun ST, Fan Z, Josten M, Sahl HG, Wang Q, Luo YM, Liu SJ, Dahl C, Jiang CY.

J Biol Chem. 2014 Sep 26;289(39):26949-59. doi: 10.1074/jbc.M114.591669. Epub 2014 Aug 13.

13.

AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae.

Klöckner A, Otten C, Derouaux A, Vollmer W, Bühl H, De Benedetti S, Münch D, Josten M, Mölleken K, Sahl HG, Henrichfreise B.

Nat Commun. 2014 Jun 23;5:4201. doi: 10.1038/ncomms5201.

14.

Bactericidal activity of the human skin fatty acid cis-6-hexadecanoic acid on Staphylococcus aureus.

Cartron ML, England SR, Chiriac AI, Josten M, Turner R, Rauter Y, Hurd A, Sahl HG, Jones S, Foster SJ.

Antimicrob Agents Chemother. 2014 Jul;58(7):3599-609. doi: 10.1128/AAC.01043-13. Epub 2014 Apr 7.

15.

Small cationic antimicrobial peptides delocalize peripheral membrane proteins.

Wenzel M, Chiriac AI, Otto A, Zweytick D, May C, Schumacher C, Gust R, Albada HB, Penkova M, Krämer U, Erdmann R, Metzler-Nolte N, Straus SK, Bremer E, Becher D, Brötz-Oesterhelt H, Sahl HG, Bandow JE.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1409-18. doi: 10.1073/pnas.1319900111. Epub 2014 Mar 24.

16.

New proteins involved in sulfur trafficking in the cytoplasm of Allochromatium vinosum.

Stockdreher Y, Sturm M, Josten M, Sahl HG, Dobler N, Zigann R, Dahl C.

J Biol Chem. 2014 May 2;289(18):12390-403. doi: 10.1074/jbc.M113.536425. Epub 2014 Mar 19.

17.

The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.

Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio M, Donadio S, Wimmer R, Sahl HG.

J Biol Chem. 2014 Apr 25;289(17):12063-76. doi: 10.1074/jbc.M113.537449. Epub 2014 Mar 13.

18.

Characterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae.

De Benedetti S, Bühl H, Gaballah A, Klöckner A, Otten C, Schneider T, Sahl HG, Henrichfreise B.

Front Cell Infect Microbiol. 2014 Feb 26;4:19. doi: 10.3389/fcimb.2014.00019. eCollection 2014.

19.

Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus.

Schreiber F, Szekat C, Josten M, Sahl HG, Bierbaum G.

Antimicrob Agents Chemother. 2013 Dec;57(12):6381-4. doi: 10.1128/AAC.01585-13. Epub 2013 Sep 30.

20.

Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages.

Josten M, Reif M, Szekat C, Al-Sabti N, Roemer T, Sparbier K, Kostrzewa M, Rohde H, Sahl HG, Bierbaum G.

J Clin Microbiol. 2013 Jun;51(6):1809-17. doi: 10.1128/JCM.00518-13. Epub 2013 Apr 3.

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