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Items: 9


A feasibility study exploring the role of pre-operative assessment when examining the mechanism of 'chemo-brain' in breast cancer patients.

Jenkins V, Thwaites R, Cercignani M, Sacre S, Harrison N, Whiteley-Jones H, Mullen L, Chamberlain G, Davies K, Zammit C, Matthews L, Harder H.

Springerplus. 2016 Mar 31;5:390. doi: 10.1186/s40064-016-2030-y. eCollection 2016.


Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures.

Mullen L, Ferdjani J, Sacre S.

Mol Med. 2015 Aug 24. doi: 10.2119/molmed.2015.00154. [Epub ahead of print]


Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease.

Mullen LM, Chamberlain G, Sacre S.

Arthritis Res Ther. 2015 May 15;17:122. doi: 10.1186/s13075-015-0645-y. Review.


Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.

Salzano S, Checconi P, Hanschmann EM, Lillig CH, Bowler LD, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri KR, Sahaf B, Herzenberg LA, Herzenberg LA, Mullen L, Ghezzi P.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12157-62. doi: 10.1073/pnas.1401712111. Epub 2014 Aug 5.


Emerging role of endosomal toll-like receptors in rheumatoid arthritis.

Thwaites R, Chamberlain G, Sacre S.

Front Immunol. 2014 Jan 16;5:1. doi: 10.3389/fimmu.2014.00001. eCollection 2014. Review.


Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance.

Alzabin S, Kong P, Medghalchi M, Palfreeman A, Williams R, Sacre S.

Arthritis Res Ther. 2012 Jun 12;14(3):R142. doi: 10.1186/ar3875.


Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

Sacre SM, Drexler SK, Andreakos E, Feldmann M, Brennan FM, Foxwell BM.

Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii81-6. Review.


The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.

Sacre SM, Andreakos E, Kiriakidis S, Amjadi P, Lundberg A, Giddins G, Feldmann M, Brennan F, Foxwell BM.

Am J Pathol. 2007 Feb;170(2):518-25.


Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?

Feldmann M, Andreakos E, Smith C, Bondeson J, Yoshimura S, Kiriakidis S, Monaco C, Gasparini C, Sacre S, Lundberg A, Paleolog E, Horwood NJ, Brennan FM, Foxwell BM.

Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii13-8. Review.

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