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Items: 1 to 20 of 207

1.

Author Correction: High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.

Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH.

Nature. 2018 May 30. doi: 10.1038/s41586-018-0187-y. [Epub ahead of print]

PMID:
29849139
2.

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates.

Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK.

Elife. 2018 May 10;7. pii: e36620. doi: 10.7554/eLife.36620. [Epub ahead of print]

3.

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging.

Mihaylova MM, Cheng CW, Cao AQ, Tripathi S, Mana MD, Bauer-Rowe KE, Abu-Remaileh M, Clavain L, Erdemir A, Lewis CA, Freinkman E, Dickey AS, La Spada AR, Huang Y, Bell GW, Deshpande V, Carmeliet P, Katajisto P, Sabatini DM, Yilmaz ÖH.

Cell Stem Cell. 2018 May 3;22(5):769-778.e4. doi: 10.1016/j.stem.2018.04.001.

PMID:
29727683
4.

NUFIP1 is a ribosome receptor for starvation-induced ribophagy.

Wyant GA, Abu-Remaileh M, Frenkel EM, Laqtom NN, Dharamdasani V, Lewis CA, Chan SH, Heinze I, Ori A, Sabatini DM.

Science. 2018 May 18;360(6390):751-758. doi: 10.1126/science.aar2663. Epub 2018 Apr 26.

PMID:
29700228
5.

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

Shen K, Huang RK, Brignole EJ, Condon KJ, Valenstein ML, Chantranupong L, Bomaliyamu A, Choe A, Hong C, Yu Z, Sabatini DM.

Nature. 2018 Apr 5;556(7699):64-69. doi: 10.1038/nature26158. Epub 2018 Mar 28.

PMID:
29590090
6.

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.

Bioorg Med Chem. 2018 May 1;26(8):1727-1739. doi: 10.1016/j.bmc.2018.02.016. Epub 2018 Feb 27.

PMID:
29555419
7.

Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites.

Chen WW, Freinkman E, Sabatini DM.

Nat Protoc. 2017 Oct;12(10):2215-2231. doi: 10.1038/nprot.2017.104. Epub 2017 Sep 29.

PMID:
29532801
8.

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.

Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.

PMID:
29452640
9.

A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.

Yuskaitis CJ, Jones BM, Wolfson RL, Super CE, Dhamne SC, Rotenberg A, Sabatini DM, Sahin M, Poduri A.

Neurobiol Dis. 2018 Mar;111:91-101. doi: 10.1016/j.nbd.2017.12.010. Epub 2017 Dec 20.

PMID:
29274432
10.

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis.

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R.

Nature. 2017 Nov 30;551(7682):639-643. doi: 10.1038/nature24637. Epub 2017 Nov 22.

11.

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

Shen K, Choe A, Sabatini DM.

Mol Cell. 2017 Nov 16;68(4):821. doi: 10.1016/j.molcel.2017.10.031. No abstract available.

12.

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

Gu X, Orozco JM, Saxton RA, Condon KJ, Liu GY, Krawczyk PA, Scaria SM, Harper JW, Gygi SP, Sabatini DM.

Science. 2017 Nov 10;358(6364):813-818. doi: 10.1126/science.aao3265.

PMID:
29123071
13.

Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

Sabatini DM.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11818-11825. doi: 10.1073/pnas.1716173114. Epub 2017 Oct 25.

14.

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes.

Abu-Remaileh M, Wyant GA, Kim C, Laqtom NN, Abbasi M, Chan SH, Freinkman E, Sabatini DM.

Science. 2017 Nov 10;358(6364):807-813. doi: 10.1126/science.aan6298. Epub 2017 Oct 26.

PMID:
29074583
15.

A CRISPR screen identifies a pathway required for paraquat-induced cell death.

Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS.

Nat Chem Biol. 2017 Dec;13(12):1274-1279. doi: 10.1038/nchembio.2499. Epub 2017 Oct 23.

16.

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

Shen K, Choe A, Sabatini DM.

Mol Cell. 2017 Nov 2;68(3):552-565.e8. doi: 10.1016/j.molcel.2017.09.026. Epub 2017 Oct 19. Erratum in: Mol Cell. 2017 Nov 16;68(4):821.

PMID:
29056322
17.

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Wyant GA, Abu-Remaileh M, Wolfson RL, Chen WW, Freinkman E, Danai LV, Vander Heiden MG, Sabatini DM.

Cell. 2017 Oct 19;171(3):642-654.e12. doi: 10.1016/j.cell.2017.09.046.

PMID:
29053970
18.

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

Wolfson RL, Sabatini DM.

Cell Metab. 2017 Aug 1;26(2):301-309. doi: 10.1016/j.cmet.2017.07.001. Review.

PMID:
28768171
19.

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD.

Immunity. 2017 Jun 20;46(6):1045-1058.e6. doi: 10.1016/j.immuni.2017.06.005.

20.

Loss of hepatic DEPTOR alters the metabolic transition to fasting.

Caron A, Mouchiroud M, Gautier N, Labbé SM, Villot R, Turcotte L, Secco B, Lamoureux G, Shum M, Gélinas Y, Marette A, Richard D, Sabatini DM, Laplante M.

Mol Metab. 2017 Feb 17;6(5):447-458. doi: 10.1016/j.molmet.2017.02.005. eCollection 2017 May.

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