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Items: 1 to 20 of 74


ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.

Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO.

Proc Natl Acad Sci U S A. 2019 Feb 6. pii: 201811923. doi: 10.1073/pnas.1811923116. [Epub ahead of print]


The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF.

Cell Rep. 2018 May 1;23(5):1476-1490. doi: 10.1016/j.celrep.2018.04.019.


Signaling Pathways Involved in the Regulation of mRNA Translation.

Roux PP, Topisirovic I.

Mol Cell Biol. 2018 May 29;38(12). pii: e00070-18. doi: 10.1128/MCB.00070-18. Print 2018 Jun 15. Review.


CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Ben Djoudi Ouadda A, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N.

Oncotarget. 2018 Jan 10;9(14):11646-11664. doi: 10.18632/oncotarget.24126. eCollection 2018 Feb 20.


RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP.

Cancer Res. 2018 May 1;78(9):2191-2204. doi: 10.1158/0008-5472.CAN-17-2215. Epub 2018 Feb 12.


Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J.

Mol Cell. 2017 Aug 3;67(3):512-527.e4. doi: 10.1016/j.molcel.2017.06.033. Epub 2017 Jul 27.


Actin cortex architecture regulates cell surface tension.

Chugh P, Clark AG, Smith MB, Cassani DAD, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch EK.

Nat Cell Biol. 2017 Jun;19(6):689-697. doi: 10.1038/ncb3525. Epub 2017 May 22.


Defining the role of the RSK isoforms in cancer.

Houles T, Roux PP.

Semin Cancer Biol. 2018 Feb;48:53-61. doi: 10.1016/j.semcancer.2017.04.016. Epub 2017 May 2. Review.


A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M.

Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.


EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G.

Blood. 2017 Jun 22;129(25):3344-3351. doi: 10.1182/blood-2016-11-750729. Epub 2017 Apr 13.


Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.

Zhang X, Lavoie G, Méant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00357-16. doi: 10.1128/MCB.00357-16. Print 2017 Apr 1.


Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.

Laflamme C, Galan JA, Ben El Kadhi K, Méant A, Zeledon C, Carréno S, Roux PP, Emery G.

Mol Cell Biol. 2017 Jan 19;37(3). pii: e00278-16. doi: 10.1128/MCB.00278-16. Print 2017 Feb 1.


High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.

J Clin Invest. 2016 Dec 1;126(12):4569-4584. doi: 10.1172/JCI86489. Epub 2016 Oct 31.


Regulation of global and specific mRNA translation by the mTOR signaling pathway.

Nandagopal N, Roux PP.

Translation (Austin). 2015 Feb 2;3(1):e983402. doi: 10.4161/21690731.2014.983402. eCollection 2015 Jan-Jun. Review.


Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5160-8. doi: 10.1073/pnas.1508836112. Epub 2015 Aug 31.


Effect of the transient pharmacological inhibition of Mapk3/1 pathway on ovulation in mice.

Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R.

PLoS One. 2015 Mar 24;10(3):e0119387. doi: 10.1371/journal.pone.0119387. eCollection 2015.


The expanding role of mTOR in cancer cell growth and proliferation.

Cargnello M, Tcherkezian J, Roux PP.

Mutagenesis. 2015 Mar;30(2):169-76. doi: 10.1093/mutage/geu045. Review.


Translational control by oncogenic signaling pathways.

Gao B, Roux PP.

Biochim Biophys Acta. 2015 Jul;1849(7):753-65. doi: 10.1016/j.bbagrm.2014.11.006. Epub 2014 Dec 2. Review.


A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.

Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG.

Nat Commun. 2014 Jul 16;5:4431. doi: 10.1038/ncomms5431.


Cellular control of cortical actin nucleation.

Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, Charras G.

Curr Biol. 2014 Jul 21;24(14):1628-1635. doi: 10.1016/j.cub.2014.05.069. Epub 2014 Jul 10.

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