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Items: 1 to 20 of 204


Absence of the dermatan sulfate chain of decorin does not affect mouse development.

Moffatt P, Geng Y, Lamplugh L, Nanci A, Roughley PJ.

J Negat Results Biomed. 2017 Apr 17;16(1):7. doi: 10.1186/s12952-017-0074-3.


Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis.

Mort JS, Geng Y, Fisher WD, Roughley PJ.

BMC Musculoskelet Disord. 2016 Feb 18;17:89. doi: 10.1186/s12891-016-0944-8.


Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor.

Rosenzweig DH, Gawri R, Moir J, Beckman L, Eglin D, Steffen T, Roughley PJ, Ouellet JA, Haglund L.

Eur Cell Mater. 2016 Jan 5;31:26-39.


TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs.

Walter BA, Likhitpanichkul M, Illien-Junger S, Roughley PJ, Hecht AC, Iatridis JC.

PLoS One. 2015 Mar 3;10(3):e0118358. doi: 10.1371/journal.pone.0118358. eCollection 2015.


Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability.

Purmessur D, Cornejo MC, Cho SK, Roughley PJ, Linhardt RJ, Hecht AC, Iatridis JC.

Spine J. 2015 May 1;15(5):1060-9. doi: 10.1016/j.spinee.2015.02.003. Epub 2015 Feb 7.


The role of aggrecan in normal and osteoarthritic cartilage.

Roughley PJ, Mort JS.

J Exp Orthop. 2014 Dec;1(1):8. doi: 10.1186/s40634-014-0008-7. Epub 2014 Jul 16.


The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism.

Roughley PJ, Geng Y, Mort JS.

Eur Cell Mater. 2014 Sep 12;28:129-36; discussion 136.


Acute mechanical injury of the human intervertebral disc: link to degeneration and pain.

Alkhatib B, Rosenzweig DH, Krock E, Roughley PJ, Beckman L, Steffen T, Weber MH, Ouellet JA, Haglund L.

Eur Cell Mater. 2014 Sep 12;28:98-110; discussion 110-1.


Cells from the skin of patients with systemic sclerosis secrete chitinase 3-like protein 1.

Ho YY, Baron M, Recklies AD, Roughley PJ, Mort JS.

BBA Clin. 2014 Jan 8;1:2-11. doi: 10.1016/j.bbacli.2013.12.001. eCollection 2014 Jun.


Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model.

Illien-Jünger S, Lu Y, Purmessur D, Mayer JE, Walter BA, Roughley PJ, Qureshi SA, Hecht AC, Iatridis JC.

Spine J. 2014 Nov 1;14(11):2724-32. doi: 10.1016/j.spinee.2014.04.017. Epub 2014 Apr 24.


Metabolic Effects of Angulation, Compression, and Reduced Mobility on Annulus Fibrosis in a Model of Altered Mechanical Environment in Scoliosis.

Stokes IA, McBride CA, Aronsson DD, Roughley PJ.

Spine Deform. 2013 May;1(3):161-170. doi: 10.1016/j.jspd.2013.02.001. Epub 2013 Jun 6.


A role for TNFα in intervertebral disc degeneration: a non-recoverable catabolic shift.

Purmessur D, Walter BA, Roughley PJ, Laudier DM, Hecht AC, Iatridis J.

Biochem Biophys Res Commun. 2013 Mar 29;433(1):151-6. doi: 10.1016/j.bbrc.2013.02.034. Epub 2013 Feb 22.


Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.

Lee HY, Han L, Roughley PJ, Grodzinsky AJ, Ortiz C.

J Struct Biol. 2013 Mar;181(3):264-73. doi: 10.1016/j.jsb.2012.12.008. Epub 2012 Dec 25.


The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells.

Antoniou J, Wang HT, Alaseem AM, Haglund L, Roughley PJ, Mwale F.

Arthritis Res Ther. 2012 Dec 10;14(6):R267. doi: 10.1186/ar4113.


The effects of chlorhexidine graft decontamination on tendon graft collagen and cell viability.

Alomar AZ, Gawri R, Roughley PJ, Haglund L, Burman M.

Am J Sports Med. 2012 Jul;40(7):1646-53. doi: 10.1177/0363546512443808. Epub 2012 Apr 20.


Extracellular matrix composition in COPD.

Annoni R, Lanças T, Yukimatsu Tanigawa R, de Medeiros Matsushita M, de Morais Fernezlian S, Bruno A, Fernando Ferraz da Silva L, Roughley PJ, Battaglia S, Dolhnikoff M, Hiemstra PS, Sterk PJ, Rabe KF, Mauad T.

Eur Respir J. 2012 Dec;40(6):1362-73. doi: 10.1183/09031936.00192611. Epub 2012 Apr 10.


Analysis of aggrecan catabolism by immunoblotting and immunohistochemistry.

Roughley PJ, Mort JS.

Methods Mol Biol. 2012;836:219-37. doi: 10.1007/978-1-61779-498-8_15.


The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration.

Mwale F, Masuda K, Pichika R, Epure LM, Yoshikawa T, Hemmad A, Roughley PJ, Antoniou J.

Arthritis Res Ther. 2011 Jul 25;13(4):R120. doi: 10.1186/ar3423.


Intervertebral disc changes with angulation, compression and reduced mobility simulating altered mechanical environment in scoliosis.

Stokes IA, McBride C, Aronsson DD, Roughley PJ.

Eur Spine J. 2011 Oct;20(10):1735-44. doi: 10.1007/s00586-011-1868-5. Epub 2011 Jun 26.

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