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Items: 1 to 20 of 404

1.

Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL.

Cell. 2017 Jan 26;168(3):377-389.e12. doi: 10.1016/j.cell.2016.12.033.

PMID:
28129538
2.

Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader-Willi syndrome.

Kim Y, Lee HM, Xiong Y, Sciaky N, Hulbert SW, Cao X, Everitt JI, Jin J, Roth BL, Jiang YH.

Nat Med. 2017 Feb;23(2):213-222. doi: 10.1038/nm.4257.

PMID:
28024084
3.

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.

Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186.

PMID:
27911814
4.

Psilocybin for depression and anxiety associated with life-threatening illnesses.

McCorvy JD, Olsen RH, Roth BL.

J Psychopharmacol. 2016 Dec;30(12):1209-1210. No abstract available.

PMID:
27909171
5.

Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists.

Chen X, McCorvy JD, Fischer MG, Butler KV, Shen Y, Roth BL, Jin J.

J Med Chem. 2016 Dec 8;59(23):10601-10618.

PMID:
27805392
6.

Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.

Sato S, Huang XP, Kroeze WK, Roth BL.

Mol Pharmacol. 2016 Dec;90(6):726-737.

PMID:
27754899
7.

Translating genome-wide association findings into new therapeutics for psychiatry.

Breen G, Li Q, Roth BL, O'Donnell P, Didriksen M, Dolmetsch R, O'Reilly PF, Gaspar HA, Manji H, Huebel C, Kelsoe JR, Malhotra D, Bertolino A, Posthuma D, Sklar P, Kapur S, Sullivan PF, Collier DA, Edenberg HJ.

Nat Neurosci. 2016 Oct 26;19(11):1392-1396. doi: 10.1038/nn.4411.

PMID:
27786187
8.

Design and Discovery of Functionally Selective Serotonin 2C (5-HT2C) Receptor Agonists.

Cheng J, McCorvy JD, Giguere PM, Zhu H, Kenakin T, Roth BL, Kozikowski AP.

J Med Chem. 2016 Nov 10;59(21):9866-9880.

PMID:
27726356
9.

Structure-based discovery of opioid analgesics with reduced side effects.

Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK.

Nature. 2016 Sep 8;537(7619):185-190. doi: 10.1038/nature19112.

PMID:
27533032
10.

Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.

Etukala JR, Zhu XY, Eyunni SV, Onyameh EK, Ofori E, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY.

Bioorg Med Chem. 2016 Aug 15;24(16):3671-9. doi: 10.1016/j.bmc.2016.06.011.

PMID:
27364609
11.

Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.

Ofori E, Zhu XY, Etukala JR, Peprah K, Jordan KR, Adkins AA, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY.

Bioorg Med Chem. 2016 Aug 15;24(16):3464-71. doi: 10.1016/j.bmc.2016.05.053.

PMID:
27312422
12.

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.

Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, Rice KC, Roth BL, Maier SF, Watkins LR.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3441-50. doi: 10.1073/pnas.1602070113.

13.

σ1 receptor ligands control a switch between passive and active threat responses.

Rennekamp AJ, Huang XP, Wang Y, Patel S, Lorello PJ, Cade L, Gonzales AP, Yeh JR, Caldarone BJ, Roth BL, Kokel D, Peterson RT.

Nat Chem Biol. 2016 Jul;12(7):552-8. doi: 10.1038/nchembio.2089.

14.

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D.

Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097.

15.

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.

Zhu H, Aryal DK, Olsen RH, Urban DJ, Swearingen A, Forbes S, Roth BL, Hochgeschwender U.

Genesis. 2016 Aug;54(8):439-46. doi: 10.1002/dvg.22949.

PMID:
27194399
16.

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.

Chan JD, McCorvy JD, Acharya S, Johns ME, Day TA, Roth BL, Marchant JS.

PLoS Pathog. 2016 May 17;12(5):e1005651. doi: 10.1371/journal.ppat.1005651.

17.

An alerting structure: human orexin receptor 1.

Wacker D, Roth BL.

Nat Struct Mol Biol. 2016 Apr;23(4):265-6. doi: 10.1038/nsmb.3198. No abstract available.

PMID:
27045444
18.

In Vitro and In Vivo Characterization of the Alkaloid Nuciferine.

Farrell MS, McCorvy JD, Huang XP, Urban DJ, White KL, Giguere PM, Doak AK, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt WS, Norwood AP, Webster KA, Gannon BM, Miller GW, Porter JH, Shoichet BK, Fantegrossi WE, Wetsel WC, Roth BL.

PLoS One. 2016 Mar 10;11(3):e0150602. doi: 10.1371/journal.pone.0150602.

19.

DREADDs for Neuroscientists.

Roth BL.

Neuron. 2016 Feb 17;89(4):683-94. doi: 10.1016/j.neuron.2016.01.040. Review.

20.

New Technologies for Elucidating Opioid Receptor Function.

Bruchas MR, Roth BL.

Trends Pharmacol Sci. 2016 Apr;37(4):279-89. doi: 10.1016/j.tips.2016.01.001. Review.

PMID:
26833118
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