New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Orlandi F, Coronnello M, Bellucci C, Dei S, Guandalini L, Manetti D, Martelli C, Romanelli MN, Scapecchi S, Salerno M, Menif H, Bello I, Mini E, Teodori E.
Orlandi F, et al.
Bioorg Med Chem. 2013 Jan 15;21(2):456-65. doi: 10.1016/j.bmc.2012.11.019. Epub 2012 Nov 24.
Bioorg Med Chem. 2013.
PMID: 23245571
They present a structure with a mix of flexible and rigid moieties, a property that seems critical to allow the molecules to choose the most productive of the several binding modes possible in the transporter recognition site. In particular, compounds 5c and 5d, similar to …
They present a structure with a mix of flexible and rigid moieties, a property that seems critical to allow the molecules to choose the most …