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Bok regulates mitochondrial fusion and morphology.

Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE 2nd, Yule DI, Wojcikiewicz RJH.

Cell Death Differ. 2019 Apr 11. doi: 10.1038/s41418-019-0327-4. [Epub ahead of print]


Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell.

Kono T, Tong X, Taleb S, Bone RN, Iida H, Lee CC, Sohn P, Gilon P, Roe MW, Evans-Molina C.

Diabetes. 2018 Nov;67(11):2293-2304. doi: 10.2337/db17-1351. Epub 2018 Aug 21.


Interplay between ER Ca2+ Binding Proteins, STIM1 and STIM2, Is Required for Store-Operated Ca2+ Entry.

Nelson HA, Leech CA, Kopp RF, Roe MW.

Int J Mol Sci. 2018 May 19;19(5). pii: E1522. doi: 10.3390/ijms19051522.


Molecular physiology and pathophysiology of stromal interaction molecules.

Nelson HA, Roe MW.

Exp Biol Med (Maywood). 2018 Mar;243(5):451-472. doi: 10.1177/1535370218754524. Epub 2018 Jan 24. Review.


Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells.

Leech CA, Kopp RF, Nelson HA, Nandi J, Roe MW.

J Biol Chem. 2017 Feb 10;292(6):2266-2277. doi: 10.1074/jbc.M116.767681. Epub 2016 Dec 21.


Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Oct 10;6:34969. doi: 10.1038/srep34969. No abstract available.


IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN.

Sci Rep. 2016 Jul 5;6:28177. doi: 10.1038/srep28177. Erratum in: Sci Rep. 2016 Oct 10;6:34969.


GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.

Chepurny OG, Holz GG, Roe MW, Leech CA.

Mol Endocrinol. 2016 Jun;30(6):614-29. doi: 10.1210/me.2015-1306. Epub 2016 Apr 15.


Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

Kim K, Oh CM, Ohara-Imaizumi M, Park S, Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty G, Nagamatsu S, German MS, Kim H.

Endocrinology. 2015 Feb;156(2):444-52. doi: 10.1210/en.2014-1687. Epub 2014 Nov 26.


Resveratrol Interferes with Fura-2 Intracellular Calcium Measurements.

Kopp RF, Leech CA, Roe MW.

J Fluoresc. 2014 Mar;24(2):279-84. doi: 10.1007/s10895-013-1312-9. Epub 2013 Oct 23.


Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR.

J Biol Chem. 2013 Nov 22;288(47):33824-36. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10.


Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death.

Brickley DR, Agyeman AS, Kopp RF, Hall BA, Harbeck MC, Belova L, Volden PA, Wu W, Roe MW, Conzen SD.

J Biol Chem. 2013 Nov 8;288(45):32708-19. doi: 10.1074/jbc.M113.507210. Epub 2013 Sep 16.


β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.

Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B.

Diabetes. 2013 May;62(5):1527-36. doi: 10.2337/db12-1013. Epub 2013 Jan 24.


Gating of connexin 43 gap junctions by a cytoplasmic loop calmodulin binding domain.

Xu Q, Kopp RF, Chen Y, Yang JJ, Roe MW, Veenstra RD.

Am J Physiol Cell Physiol. 2012 May 15;302(10):C1548-56. doi: 10.1152/ajpcell.00319.2011. Epub 2012 Mar 14.


Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.


Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.

Islets. 2009 Nov-Dec;1(3):260-5. doi: 10.4161/isl.1.3.9645.


Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.


Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ.

Diabetes. 2010 Dec;59(12):3090-8. doi: 10.2337/db10-0624. Epub 2010 Aug 29.


PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E622-33. doi: 10.1152/ajpendo.00630.2009. Epub 2009 Dec 15.

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