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Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.

Rodríguez-Muñoz M, Onetti Y, Cortés-Montero E, Garzón J, Sánchez-Blázquez P.

Mol Brain. 2018 Sep 17;11(1):51. doi: 10.1186/s13041-018-0395-2.


Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.

Sánchez-Blázquez P, Cortés-Montero E, Rodríguez-Muñoz M, Garzón J.

Int J Neuropsychopharmacol. 2018 Oct 1;21(10):938-948. doi: 10.1093/ijnp/pyy049.


Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Garzón J.

Oncotarget. 2018 May 4;9(34):23373-23389. doi: 10.18632/oncotarget.25169. eCollection 2018 May 4.


The structure of the Patient Health Questionnaire-9 in pregnant women in Spain.

Marcos-Nájera R, Le HN, Rodríguez-Muñoz MF, Olivares Crespo ME, Izquierdo Mendez N.

Midwifery. 2018 Jul;62:36-41. doi: 10.1016/j.midw.2018.03.011. Epub 2018 Mar 27.


Schizophrenia and depression, two poles of endocannabinoid system deregulation.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Callado LF, Meana JJ, Garzón-Niño J.

Transl Psychiatry. 2017 Dec 18;7(12):1291. doi: 10.1038/s41398-017-0029-y.


[Psychometric properties of postpartum depression predictors inventory- revised- prenatal version in a sample of spanish pregnant women.]

Rodríguez-Muñoz MF, Vallejo Slocker L, Olivares Crespo ME, Izquierdo Méndez N, Soto C, Le HN.

Rev Esp Salud Publica. 2017 Dec 15;91. pii: e201712047. Spanish.


nandb-number and brightness in R with a novel automatic detrending algorithm.

Nolan R, Alvarez LAJ, Elegheert J, Iliopoulou M, Jakobsdottir GM, Rodriguez-Muñoz M, Aricescu AR, Padilla-Parra S.

Bioinformatics. 2017 Nov 1;33(21):3508-3510. doi: 10.1093/bioinformatics/btx434.


Delayed tension pneumoperitoneum after colonoscopy.

Serrano-Dueñas M, Rodriguez-Muñoz MJ, Portilla-Botelho M.

Med Intensiva. 2018 Oct;42(7):e18. doi: 10.1016/j.medin.2017.06.002. Epub 2017 Jul 9. English, Spanish. No abstract available.


Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces.

Garzón-Niño J, Rodríguez-Muñoz M, Cortés-Montero E, Sánchez-Blázquez P.

Sci Rep. 2017 Feb 27;7:43468. doi: 10.1038/srep43468.


[PHQ-2 as First Screening Instrument of Prenatal Depression in Primary Health Care, Spain].

Rodríguez-Muñoz MF, Castelao Legazpi PC, Olivares Crespo ME, Soto Balbuena C, Izquierdo Méndez N, Ferrer Barrientos FJ, Huynh-Nhu L.

Rev Esp Salud Publica. 2017 Jan 30;91. pii: e201701010. Spanish.


Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Merlos M, Garzón-Niño J.

Oncotarget. 2016 Aug 23;7(34):55840-55862. doi: 10.18632/oncotarget.10095. Review.


The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.

Rodríguez-Muñoz M, Cortés-Montero E, Pozo-Rodrigálvarez A, Sánchez-Blázquez P, Garzón-Niño J.

Oncotarget. 2015 Nov 3;6(34):35458-77. doi: 10.18632/oncotarget.6064.


The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Herrero-Labrador R, Martínez-Murillo R, Merlos M, Vela JM, Garzón J.

Antioxid Redox Signal. 2015 Apr 1;22(10):799-818. doi: 10.1089/ars.2014.5993. Epub 2015 Feb 18.


HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia.

Garzón J, Herrero-Labrador R, Rodríguez-Muñoz M, Shah R, Vicente-Sánchez A, Wagner CR, Sánchez-Blázquez P.

Neuropharmacology. 2015 Feb;89:412-23.


Detecting zinc release induced by mu-opioid receptor agonists in brain slices.

Rodríguez-Muñoz M, Sánchez-Blázquez P, Bailón C, Garzón J.

Methods Mol Biol. 2015;1230:233-41. doi: 10.1007/978-1-4939-1708-2_19.


The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.

Sánchez-Blázquez P, Rodríguez-Muñoz M, Herrero-Labrador R, Burgueño J, Zamanillo D, Garzón J.

Int J Neuropsychopharmacol. 2014 Dec;17(12):1943-55. doi: 10.1017/S1461145714000029. Epub 2014 Jan 31.


The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia.

Sánchez-Blázquez P, Rodríguez-Muñoz M, Garzón J.

Front Pharmacol. 2014 Jan 2;4:169. doi: 10.3389/fphar.2013.00169. Review.


HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.

Vicente-Sánchez A, Sánchez-Blázquez P, Rodríguez-Muñoz M, Garzón J.

Mol Brain. 2013 Oct 5;6:42. doi: 10.1186/1756-6606-6-42.


Nitric oxide and zinc-mediated protein assemblies involved in mu opioid receptor signaling.

Rodríguez-Muñoz M, Garzón J.

Mol Neurobiol. 2013 Dec;48(3):769-82. doi: 10.1007/s12035-013-8465-z. Epub 2013 May 11. Review.


Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate.

Sánchez-Blázquez P, Rodríguez-Muñoz M, Vicente-Sánchez A, Garzón J.

Antioxid Redox Signal. 2013 Nov 20;19(15):1766-82. doi: 10.1089/ars.2012.5100. Epub 2013 Jun 1.

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