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Items: 1 to 20 of 190

1.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9.

Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, Shenoy SK, Laporte SA, Rockman HA, Lefkowitz RJ.

Sci Signal. 2018 Sep 25;11(549). pii: eaat7650. doi: 10.1126/scisignal.aat7650.

PMID:
30254056
2.

The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.

Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang HG, Frangakis S, Pitt GS, Shah SH, Wolf MJ, Rockman HA.

J Clin Invest. 2018 Aug 28. pii: 95945. doi: 10.1172/JCI95945. [Epub ahead of print]

3.

Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery.

Wisler JW, Rockman HA, Lefkowitz RJ.

Circulation. 2018 May 29;137(22):2315-2317. doi: 10.1161/CIRCULATIONAHA.117.028194. No abstract available.

PMID:
29844068
4.

We're listening.

Rockman HA.

JCI Insight. 2018 Jan 25;3(2). pii: 99456. doi: 10.1172/jci.insight.99456. [Epub ahead of print] No abstract available.

5.

Mechanoactivation of the angiotensin II type 1 receptor induces β-arrestin-biased signaling through Gαi coupling.

Wang J, Hanada K, Gareri C, Rockman HA.

J Cell Biochem. 2018 Apr;119(4):3586-3597. doi: 10.1002/jcb.26552. Epub 2018 Jan 4.

6.

i is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling.

Wang J, Hanada K, Staus DP, Makara MA, Dahal GR, Chen Q, Ahles A, Engelhardt S, Rockman HA.

Nat Commun. 2017 Nov 22;8(1):1706. doi: 10.1038/s41467-017-01855-z.

7.

Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.

Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK.

JCI Insight. 2017 Sep 7;2(17). pii: 95998. doi: 10.1172/jci.insight.95998. [Epub ahead of print]

8.

לְדוֹר וָדוֹר.

Rockman HA.

J Clin Invest. 2017 Jun 1;127(6):2019-2020. doi: 10.1172/JCI94813. Epub 2017 Jun 1.

9.

A successful launch.

Rockman HA.

JCI Insight. 2017 Jan 26;2(2):e92800. doi: 10.1172/jci.insight.92800. No abstract available.

10.

β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility.

Abraham DM, Davis RT 3rd, Warren CM, Mao L, Wolska BM, Solaro RJ, Rockman HA.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14426-14431. Epub 2016 Nov 28.

11.

Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.

Watson LJ, Alexander KM, Mohan ML, Bowman AL, Mangmool S, Xiao K, Naga Prasad SV, Rockman HA.

Cell Signal. 2016 Oct;28(10):1580-92. doi: 10.1016/j.cellsig.2016.05.006. Epub 2016 May 8.

12.

G Protein-coupled Receptor Biased Agonism.

Hodavance SY, Gareri C, Torok RD, Rockman HA.

J Cardiovasc Pharmacol. 2016 Mar;67(3):193-202. doi: 10.1097/FJC.0000000000000356. Review.

13.

Pacemaker-induced transient asynchrony suppresses heart failure progression.

Kirk JA, Chakir K, Lee KH, Karst E, Holewinski RJ, Pironti G, Tunin RS, Pozios I, Abraham TP, de Tombe P, Rockman HA, Van Eyk JE, Craig R, Farazi TG, Kass DA.

Sci Transl Med. 2015 Dec 23;7(319):319ra207. doi: 10.1126/scitranslmed.aad2899.

14.

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.

Xu W, Barrientos T, Mao L, Rockman HA, Sauve AA, Andrews NC.

Cell Rep. 2015 Oct 20;13(3):533-545. doi: 10.1016/j.celrep.2015.09.023. Epub 2015 Oct 8.

15.

The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome.

Wisler JW, Harris EM, Raisch M, Mao L, Kim J, Rockman HA, Lefkowitz RJ.

Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1516-27. doi: 10.1152/ajpheart.00291.2015. Epub 2015 Sep 14.

16.

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

Pironti G, Strachan RT, Abraham D, Mon-Wei Yu S, Chen M, Chen W, Hanada K, Mao L, Watson LJ, Rockman HA.

Circulation. 2015 Jun 16;131(24):2120-30. doi: 10.1161/CIRCULATIONAHA.115.015687. Epub 2015 May 20.

17.

Happy birthday JCI.

Rockman HA.

J Clin Invest. 2014 Oct;124(10):4135-6. doi: 10.1172/JCI78708. Epub 2014 Oct 1.

18.

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.

Tang W, Strachan RT, Lefkowitz RJ, Rockman HA.

J Biol Chem. 2014 Oct 10;289(41):28271-83. doi: 10.1074/jbc.M114.585067. Epub 2014 Aug 28.

19.

Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila.

Lee TE, Yu L, Wolf MJ, Rockman HA.

Genetics. 2014 Oct;198(2):591-603. doi: 10.1534/genetics.114.166777. Epub 2014 Jul 31.

20.

Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent.

Ashton JR, Befera N, Clark D, Qi Y, Mao L, Rockman HA, Johnson GA, Badea CT.

Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):161-8. doi: 10.1002/cmmi.1557.

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