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Rev Esp Cardiol (Engl Ed). 2019 Jun;72(6):487-494. doi: 10.1016/j.rec.2018.12.010. Epub 2019 May 1.

The Two-way Relationship Between Cancer and Atherosclerosis.

[Article in English, Spanish]

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Departamento de Cardiología, Hospital Universitario Álvaro Cunqueiro, Instituto de Investigación Sanitaria Galicia Sur, Vigo, Pontevedra, Spain. Electronic address:
Departamento de Cardiología, Hospital Universitario de San Juan, San Juan de Alicante, Alicante, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.


In the last few years, there has been growing interest in the relationship between cancer and cardiovascular disease. The increase in life expectancy in both diseases has led to their frequent coexistence in the same patient, which can lead to adverse drug reactions that increase patient risk. This is especially relevant in the case of atherosclerosis, which seems to share a common pathophysiological substrate with cancer. In this review, we analyze these common risk factors, and specifically analyze the relationship between different cancer treatments with the risk of coronary or cerebrovascular disease, as well as the current scientific evidence on the possible relationship between antiplatelet therapy and cancer risk. We also review the incidence and prognosis of cancer in patients with atherosclerosis and vice versa, based on the information reported in the most recently published studies in the field of cardio-oncology.


Antiplatelet therapy; Ateroesclerosis; Atherosclerosis; Cancer; Cardiopatía isquémica; Cáncer; Fármacos antiagregantes; Ischemic heart disease


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