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Items: 1 to 20 of 162

1.

Expression and functional characterization of breast cancer-associated cytochrome P450 4Z1 in Saccharomyces cerevisiae.

McDonald MG, Ray S, Amorosi CJ, Sitko KA, Kowalski JP, Paco L, Nath A, Gallis BM, Totah RA, Dunham MJ, Fowler DM, Rettie AE.

Drug Metab Dispos. 2017 Oct 10. pii: dmd.117.078188. doi: 10.1124/dmd.117.078188. [Epub ahead of print]

PMID:
29018033
2.

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.

Xu M, Bhatt DK, Yeung CK, Claw KG, Chaudhry AS, Gaedigk A, Pearce RE, Broeckel U, Gaedigk R, Nickerson DA, Schuetz E, Rettie AE, Leeder JS, Thummel KE, Prasad B.

J Pharmacol Exp Ther. 2017 Nov;363(2):265-274. doi: 10.1124/jpet.117.243113. Epub 2017 Aug 17.

3.

Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2.

Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ.

Br J Ophthalmol. 2017 Jul 11. pii: bjophthalmol-2016-309696. doi: 10.1136/bjophthalmol-2016-309696. [Epub ahead of print]

PMID:
28698241
4.

Dietary and genetic influences on hemostasis in a Yup'ik Alaska Native population.

Au NT, Reyes M, Boyer BB, Hopkins SE, Black J, O'Brien D, Fohner AE, Yracheta J, Thornton T, Austin MA, Burke W, Thummel KE, Rettie AE.

PLoS One. 2017 Apr 4;12(4):e0173616. doi: 10.1371/journal.pone.0173616. eCollection 2017.

5.

The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.

Hsu MH, Baer BR, Rettie AE, Johnson EF.

J Biol Chem. 2017 Mar 31;292(13):5610-5621. doi: 10.1074/jbc.M117.775494. Epub 2017 Feb 6.

6.

Ligand characterization of CYP4B1 isoforms modified for high-level expression in Escherichia coli and HepG2 cells.

Roellecke K, Jäger VD, Gyurov VH, Kowalski JP, Mielke S, Rettie AE, Hanenberg H, Wiek C, Girhard M.

Protein Eng Des Sel. 2017 Mar 1;30(3):205-216. doi: 10.1093/protein/gzw075.

PMID:
28073960
7.

CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites.

Flora DR, Rettie AE, Brundage RC, Tracy TS.

J Clin Pharmacol. 2017 Mar;57(3):382-393. doi: 10.1002/jcph.813. Epub 2016 Sep 22.

PMID:
27539372
8.

Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients.

Robinson-Cohen C, Newitt R, Shen DD, Rettie AE, Kestenbaum BR, Himmelfarb J, Yeung CK.

PLoS One. 2016 Aug 11;11(8):e0161074. doi: 10.1371/journal.pone.0161074. eCollection 2016.

9.

Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.

Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE.

Drug Metab Dispos. 2016 Oct;44(10):1598-602. doi: 10.1124/dmd.116.070003. Epub 2016 Jul 28.

10.

Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib.

Towles JK, Clark RN, Wahlin MD, Uttamsingh V, Rettie AE, Jackson KD.

Drug Metab Dispos. 2016 Oct;44(10):1584-97. doi: 10.1124/dmd.116.070839. Epub 2016 Jul 22.

11.

Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies.

Roellecke K, Virts EL, Einholz R, Edson KZ, Altvater B, Rossig C, von Laer D, Scheckenbach K, Wagenmann M, Reinhardt D, Kramm CM, Rettie AE, Wiek C, Hanenberg H.

Gene Ther. 2016 Jul;23(7):615-26. doi: 10.1038/gt.2016.38. Epub 2016 May 19.

PMID:
27092941
12.

Efficient Syntheses of Vitamin K Chain-Shortened Acid Metabolites.

Teitelbaum AM, Scian M, Nelson WL, Rettie AE.

Synthesis (Stuttg). 2015 Apr;47(7):944-948.

13.

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H.

PLoS One. 2015 Sep 10;10(9):e0137110. doi: 10.1371/journal.pone.0137110. eCollection 2015.

14.

Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content.

Shirasaka Y, Chaudhry AS, McDonald M, Prasad B, Wong T, Calamia JC, Fohner A, Thornton TA, Isoherranen N, Unadkat JD, Rettie AE, Schuetz EG, Thummel KE.

Pharmacogenomics J. 2016 Aug;16(4):375-87. doi: 10.1038/tpj.2015.58. Epub 2015 Sep 1.

15.

P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms.

McDonald MG, Au NT, Rettie AE.

Drug Metab Dispos. 2015 Nov;43(11):1661-9. doi: 10.1124/dmd.115.065623. Epub 2015 Aug 21.

16.

Genome-wide association study of warfarin maintenance dose in a Brazilian sample.

Parra EJ, Botton MR, Perini JA, Krithika S, Bourgeois S, Johnson TA, Tsunoda T, Pirmohamed M, Wadelius M, Limdi NA, Cavallari LH, Burmester JK, Rettie AE, Klein TE, Johnson JA, Hutz MH, Suarez-Kurtz G.

Pharmacogenomics. 2015;16(11):1253-63. doi: 10.2217/PGS.15.73. Epub 2015 Aug 12.

17.

Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer.

Johnson AL, Edson KZ, Totah RA, Rettie AE.

Adv Pharmacol. 2015;74:223-62. doi: 10.1016/bs.apha.2015.05.002. Epub 2015 Jun 27. Review.

18.

Variation in genes controlling warfarin disposition and response in American Indian and Alaska Native people: CYP2C9, VKORC1, CYP4F2, CYP4F11, GGCX.

Fohner AE, Robinson R, Yracheta J, Dillard DA, Schilling B, Khan B, Hopkins S, Boyer B, Black J, Wiener H, Tiwari HK, Gordon A, Nickerson D, Tsai JM, Farin FM, Thornton TA, Rettie AE, Thummel KE.

Pharmacogenet Genomics. 2015 Jul;25(7):343-353. doi: 10.1097/FPC.0000000000000143.

19.

Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.

Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE.

PLoS One. 2014 Oct 15;9(10):e110054. doi: 10.1371/journal.pone.0110054. eCollection 2014.

20.

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H.

Biochem J. 2015 Jan 1;465(1):103-14. doi: 10.1042/BJ20140813.

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