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J Obstet Gynecol Neonatal Nurs. 2013 Nov-Dec;42(6):737-48. doi: 10.1111/1552-6909.12248. Epub 2013 Oct 15.

Heredity of restless legs syndrome in a pregnant population.

Abstract

OBJECTIVE:

To synthesize published research on genetic and heredity findings related to restless legs syndrome (RLS) in a pregnant population.

DATA SOURCES:

PubMed, CINAHL, and PsycINFO databases and reference lists from published articles.

STUDY SELECTION:

Literature searches were conducted for primary research studies published in English on the genetic and heredity findings of RLS in pregnant populations.

DATA EXTRACTION:

Study characteristics and findings related to genetic and heredity aspects of RLS in a pregnant population.

DATA SYNTHESIS:

Five data-based articles met the criteria for study inclusion. Study findings comprised Level-2 and Level-3 evidence. Four of the five studies were larger population studies and contained a subset of pregnant participants. Parity and family history were important predictors of RLS proband status. Probands reported symptoms were often initiated during or after pregnancy.

CONCLUSIONS:

Symptoms of RLS for female probands are often initiated during pregnancy or after childbirth. A history of RLS in a previous pregnancy and family history of RLS were strong predictors of RLS in the current pregnancy. Future research on genetic associations of RLS in pregnancy is warranted.

KEYWORDS:

family history; gender; genetics; heredity; pregnancy; restless legs syndrome

PMID:
24128048
DOI:
10.1111/1552-6909.12248
[Indexed for MEDLINE]
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