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Items: 1 to 20 of 107


Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major.

Lombraña R, Álvarez A, Fernández-Justel JM, Almeida R, Poza-Carrión C, Gomes F, Calzada A, Requena JM, Gómez M.

Cell Rep. 2016 Aug 9;16(6):1774-86. doi: 10.1016/j.celrep.2016.07.007.


A putative Leishmania DNA polymerase theta protects the parasite against oxidative damage.

Fernández-Orgiler A, Martínez-Jiménez MI, Alonso A, Alcolea PJ, Requena JM, Thomas MC, Blanco L, Larraga V.

Nucleic Acids Res. 2016 Jun 2;44(10):4855-70. doi: 10.1093/nar/gkw346.


Resequencing and assembly of seven complex loci to improve the Leishmania major (Friedlin strain) reference genome.

Alonso G, Rastrojo A, López-Pérez S, Requena JM, Aguado B.

Parasit Vectors. 2016 Feb 8;9:74. doi: 10.1186/s13071-016-1329-4.


Molecular Chaperones of Leishmania: Central Players in Many Stress-Related and -Unrelated Physiological Processes.

Requena JM, Montalvo AM, Fraga J.

Biomed Res Int. 2015;2015:301326. doi: 10.1155/2015/301326. Review.


[Detection of Leishmania spp. based on the gene encoding HSP20].

Montalvo AM, Fraga J, Rodríguez O, Blanco O, Llanos-Cuentas A, García AL, Valencia BM, Muskus C, Van der Auwera G, Requena JM.

Rev Peru Med Exp Salud Publica. 2014 Oct-Dec;31(4):635-43. Spanish.


Leishmania braziliensis replication protein A subunit 1: molecular modelling, protein expression and analysis of its affinity for both DNA and RNA.

Nocua PA, Ramirez CA, Barreto GE, González J, Requena JM, Puerta CJ.

Parasit Vectors. 2014 Dec 12;7:573. doi: 10.1186/s13071-014-0573-8.


Identification of proteins interacting with HSP70 mRNAs in Leishmania braziliensis.

Ramírez CA, Dea-Ayuela MA, Gutiérrez-Blázquez MD, Bolas-Fernández F, Requena JM, Puerta CJ.

J Proteomics. 2013 Dec 6;94:124-37. doi: 10.1016/j.jprot.2013.09.008.


Alpha tubulin genes from Leishmania braziliensis: genomic organization, gene structure and insights on their expression.

Ramírez CA, Requena JM, Puerta CJ.

BMC Genomics. 2013 Jul 6;14:454. doi: 10.1186/1471-2164-14-454.


Evolution and species discrimination according to the Leishmania heat-shock protein 20 gene.

Fraga J, Montalvo AM, Van der Auwera G, Maes I, Dujardin JC, Requena JM.

Infect Genet Evol. 2013 Aug;18:229-37. doi: 10.1016/j.meegid.2013.05.020.


The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq.

Rastrojo A, Carrasco-Ramiro F, Martín D, Crespillo A, Reguera RM, Aguado B, Requena JM.

BMC Genomics. 2013 Apr 4;14:223. doi: 10.1186/1471-2164-14-223.


Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect.

Prada CF, Alvarez-Velilla R, Balaña-Fouce R, Prieto C, Calvo-Álvarez E, Escudero-Martínez JM, Requena JM, Ordóñez C, Desideri A, Pérez-Pertejo Y, Reguera RM.

Biochem Pharmacol. 2013 May 15;85(10):1433-40. doi: 10.1016/j.bcp.2013.02.024.


Appraisal of a Leishmania major strain stably expressing mCherry fluorescent protein for both in vitro and in vivo studies of potential drugs and vaccine against cutaneous leishmaniasis.

Calvo-Álvarez E, Guerrero NA, Alvarez-Velilla R, Prada CF, Requena JM, Punzón C, Llamas MÁ, Arévalo FJ, Rivas L, Fresno M, Pérez-Pertejo Y, Balaña-Fouce R, Reguera RM.

PLoS Negl Trop Dis. 2012;6(11):e1927. doi: 10.1371/journal.pntd.0001927.


Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis.

Balaña-Fouce R, Prada CF, Requena JM, Cushman M, Pommier Y, Álvarez-Velilla R, Escudero-Martínez JM, Calvo-Álvarez E, Pérez-Pertejo Y, Reguera RM.

Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. doi: 10.1128/AAC.00499-12.


Sequence analysis of the 3'-untranslated region of HSP70 (type I) genes in the genus Leishmania: its usefulness as a molecular marker for species identification.

Requena JM, Chicharro C, García L, Parrado R, Puerta CJ, Cañavate C.

Parasit Vectors. 2012 Apr 28;5:87. doi: 10.1186/1756-3305-5-87.


Immunity to visceral leishmaniasis.

Ali N, Mekuria AH, Requena JM, Engwerda C.

J Trop Med. 2012;2012:780809. doi: 10.1155/2012/780809. No abstract available.


Identification of the HSP70-II gene in Leishmania braziliensis HSP70 locus: genomic organization and UTRs characterization.

Ramírez CA, Requena JM, Puerta CJ.

Parasit Vectors. 2011 Aug 26;4:166. doi: 10.1186/1756-3305-4-166.


Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation.

Carrión J, Folgueira C, Soto M, Fresno M, Requena JM.

Parasit Vectors. 2011 Jul 27;4:150. doi: 10.1186/1756-3305-4-150.


Lights and shadows on gene organization and regulation of gene expression in Leishmania.

Requena JM.

Front Biosci (Landmark Ed). 2011 Jun 1;16:2069-85. Review.


Evidence of RNA editing in Leishmania braziliensis promastigotes.

Ramírez C, Puerta C, Requena JM.

Parasitol Res. 2011 Mar;108(3):731-9. doi: 10.1007/s00436-010-2190-6.


The Leishmania infantum PUF proteins are targets of the humoral response during visceral leishmaniasis.

Folgueira C, Martínez-Bonet M, Requena JM.

BMC Res Notes. 2010 Jan 21;3:13. doi: 10.1186/1756-0500-3-13.

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