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Items: 1 to 20 of 99


Leishmania donovani chaperonin 10 regulates parasite internalization and intracellular survival in human macrophages.

Colineau L, Clos J, Moon KM, Foster LJ, Reiner NE.

Med Microbiol Immunol. 2017 Jun;206(3):235-257. doi: 10.1007/s00430-017-0500-7. Epub 2017 Mar 11.


Comprehensive Identification of mRNA-Binding Proteins of Leishmania donovani by Interactome Capture.

Nandan D, Thomas SA, Nguyen A, Moon KM, Foster LJ, Reiner NE.

PLoS One. 2017 Jan 30;12(1):e0170068. doi: 10.1371/journal.pone.0170068. eCollection 2017.


Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant.

Yau WL, Lambertz U, Colineau L, Pescher P, MacDonald A, Zander D, Retzlaff S, Eick J, Reiner NE, Clos J, Späth GF.

J Eukaryot Microbiol. 2016 Nov;63(6):823-833. doi: 10.1111/jeu.12329. Epub 2016 Jun 16.


Further investigation of inhibitors of MRSA pyruvate kinase: Towards the conception of novel antimicrobial agents.

Labrière C, Gong H, Finlay BB, Reiner NE, Young RN.

Eur J Med Chem. 2017 Jan 5;125:1-13. doi: 10.1016/j.ejmech.2016.09.018. Epub 2016 Sep 9.


Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei.

Woo PC, Lau SK, Lau CC, Tung ET, Chong KT, Yang F, Zhang H, Lo RK, Cai JP, Au-Yeung RK, Ng WF, Tse H, Wong SS, Xu S, Lam WH, Tse MK, Sze KH, Kao RY, Reiner NE, Hao Q, Yuen KY.

PLoS Negl Trop Dis. 2016 Aug 25;10(8):e0004907. doi: 10.1371/journal.pntd.0004907. eCollection 2016 Aug.


Small RNAs derived from tRNAs and rRNAs are highly enriched in exosomes from both old and new world Leishmania providing evidence for conserved exosomal RNA Packaging.

Lambertz U, Oviedo Ovando ME, Vasconcelos EJ, Unrau PJ, Myler PJ, Reiner NE.

BMC Genomics. 2015 Mar 5;16:151. doi: 10.1186/s12864-015-1260-7.


Synthetic analogues of the marine bisindole deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase.

Veale CG, Zoraghi R, Young RM, Morrison JP, Pretheeban M, Lobb KA, Reiner NE, Andersen RJ, Davies-Coleman MT.

J Nat Prod. 2015 Mar 27;78(3):355-62. doi: 10.1021/np500755v. Epub 2014 Nov 5.


Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.

Zoraghi R, Campbell S, Kim C, Dullaghan EM, Blair LM, Gillard RM, Reiner NE, Sperry J.

Bioorg Med Chem Lett. 2014 Nov 1;24(21):5059-62. doi: 10.1016/j.bmcl.2014.09.010. Epub 2014 Sep 16.


Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections.

Kumar NS, Dullaghan EM, Finlay BB, Gong H, Reiner NE, Jon Paul Selvam J, Thorson LM, Campbell S, Vitko N, Richardson AR, Zoraghi R, Young RN.

Bioorg Med Chem. 2014 Mar 1;22(5):1708-25. doi: 10.1016/j.bmc.2014.01.020. Epub 2014 Jan 24.


Protein interaction networks as starting points to identify novel antimicrobial drug targets.

Zoraghi R, Reiner NE.

Curr Opin Microbiol. 2013 Oct;16(5):566-72. doi: 10.1016/j.mib.2013.07.010. Epub 2013 Aug 10. Review.


Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase.

Chan BC, Ip M, Gong H, Lui SL, See RH, Jolivalt C, Fung KP, Leung PC, Reiner NE, Lau CB.

Phytomedicine. 2013 May 15;20(7):611-4. doi: 10.1016/j.phymed.2013.02.007. Epub 2013 Mar 27.


Identification of the Mycobacterium tuberculosis protein PE-PGRS62 as a novel effector that functions to block phagosome maturation and inhibit iNOS expression.

Thi EP, Hong CJ, Sanghera G, Reiner NE.

Cell Microbiol. 2013 May;15(5):795-808. doi: 10.1111/cmi.12073. Epub 2012 Dec 19.


Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.

Kumar NS, Amandoron EA, Cherkasov A, Finlay BB, Gong H, Jackson L, Kaur S, Lian T, Moreau A, Labrière C, Reiner NE, See RH, Strynadka NC, Thorson L, Wong EW, Worrall L, Zoraghi R, Young RN.

Bioorg Med Chem. 2012 Dec 15;20(24):7069-82. doi: 10.1016/j.bmc.2012.10.002. Epub 2012 Oct 17.


Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation.

Thi EP, Lambertz U, Reiner NE.

PLoS One. 2012;7(8):e43668. doi: 10.1371/journal.pone.0043668. Epub 2012 Aug 22.


Phosphatidylinositol 3-kinases and their roles in phagosome maturation.

Thi EP, Reiner NE.

J Leukoc Biol. 2012 Sep;92(3):553-66. doi: 10.1189/jlb.0212053. Epub 2012 May 8. Review.


Sleeping with the enemy: how intracellular pathogens cope with a macrophage lifestyle.

Thi EP, Lambertz U, Reiner NE.

PLoS Pathog. 2012;8(3):e1002551. doi: 10.1371/journal.ppat.1002551. Epub 2012 Mar 22. No abstract available.


Secreted virulence factors and immune evasion in visceral leishmaniasis.

Lambertz U, Silverman JM, Nandan D, McMaster WR, Clos J, Foster LJ, Reiner NE.

J Leukoc Biol. 2012 Jun;91(6):887-99. doi: 10.1189/jlb.0611326. Epub 2012 Mar 21. Review.


Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase.

Nandan D, Camargo de Oliveira C, Moeenrezakhanlou A, Lopez M, Silverman JM, Subek J, Reiner NE.

J Immunol. 2012 Jan 1;188(1):367-78. doi: 10.4049/jimmunol.1100076. Epub 2011 Dec 2.


Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase.

Axerio-Cilies P, See RH, Zoraghi R, Worral L, Lian T, Stoynov N, Jiang J, Kaur S, Jackson L, Gong H, Swayze R, Amandoron E, Kumar NS, Moreau A, Hsing M, Strynadka NC, McMaster WR, Finlay BB, Foster LJ, Young RN, Reiner NE, Cherkasov A.

ACS Chem Biol. 2012 Feb 17;7(2):350-9. doi: 10.1021/cb2003576. Epub 2011 Nov 21.


Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Zoraghi R, Worrall L, See RH, Strangman W, Popplewell WL, Gong H, Samaai T, Swayze RD, Kaur S, Vuckovic M, Finlay BB, Brunham RC, McMaster WR, Davies-Coleman MT, Strynadka NC, Andersen RJ, Reiner NE.

J Biol Chem. 2011 Dec 30;286(52):44716-25. doi: 10.1074/jbc.M111.289033. Epub 2011 Oct 26.

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